N,N-二乙基哌嗪-1-磺酰胺 | 98545-23-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 中文名称: N,N-二乙基哌嗪-1-磺酰胺
• 英文名称: piperazine-1-sulfonic acid diethylamide
• 英文别名: Piperazin-1-sulfonsaeure-diaethylamid；N,N-diethylpiperazine-1-sulfonamide
• CAS: 98545-23-4
• 化学式: C₈H₁₉N₃O₂S
• mdl: MFCD08239624
• 分子量: 221.324
• InChiKey: QUYMXIDXMJTALA-UHFFFAOYSA-N

物化性质

• 沸点：
  342.7±31.0 °C(Predicted)
• 密度：
  1.20±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -0.5
• 重原子数：
  14
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  61
• 氢给体数：
  1
• 氢受体数：
  5

安全信息

• 海关编码：
  2935009090

反应信息

• 作为反应物：
  描述：

  N,N-二乙基哌嗪-1-磺酰胺 、 tert-butyl 4-(((6-bromopyridin-3-yl)oxy)methyl)piperidine-1-carboxylate 在 二(三叔丁基膦)钯 、 sodium t-butanolate 作用下， 以 甲苯 为溶剂， 生成
  参考文献：
  名称：

  2,5-Disubstituted pyridines as potent GPR119 agonists

  摘要：

  A series of 2-piperazinyl-5-alkoxypyridines were synthesized and screened against human GPR119 receptor. Through SAR analysis, compounds containing 2-alkylsulfonylpiperazinyl-5-alkoxypyridines were discovered and found to be potent agonists of the human GPR119 receptor. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2010.02.083
• 作为产物：
  描述：

  Tert-butyl 4-(diethylsulfamoyl)piperazine-1-carboxylate 生成 N,N-二乙基哌嗪-1-磺酰胺
  参考文献：
  名称：

  2,5-Disubstituted pyridines as potent GPR119 agonists

  摘要：

  A series of 2-piperazinyl-5-alkoxypyridines were synthesized and screened against human GPR119 receptor. Through SAR analysis, compounds containing 2-alkylsulfonylpiperazinyl-5-alkoxypyridines were discovered and found to be potent agonists of the human GPR119 receptor. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2010.02.083

文献信息

• NOVEL INDAZOLECARBOXAMIDES, PROCESSES FOR THEIR PREPARATION, PHARMACEUTICAL PREPARATIONS COMPRISING THEM AND THEIR USE FOR PRODUCING MEDICAMENTS
  申请人：BAYER PHARMA AKTIENGESELLSCHAFT

  公开号：US20160311833A1

  公开（公告）日：2016-10-27

  The present application relates to novel 6-substituted indazoles having a carboxamide side chain, to processes for their preparation, to their use alone or in combinations for the treatment and/or prophylaxis of diseases, and to their use for producing medicaments for the treatment and/or prophylaxis of diseases, in particular for the treatment and/or prophylaxis of endometriosis, lymphomas, macular degeneration, COPD and psoriasis.

  本申请涉及具有羧酰胺侧链的新型6-取代吲唑的化合物，以及它们的制备方法，单独或组合用于治疗和/或预防疾病，以及用于制备用于治疗和/或预防疾病的药物的用途，特别是用于治疗和/或预防子宫内膜异位症、淋巴瘤、黄斑变性、慢性阻塞性肺病和牛皮癣。
• 1-substituted-4-sulfamylpiperazine and method of preparing the same
  申请人：AMERICAN CYANAMID CO

  公开号：US02748125A1

  公开（公告）日：1956-05-29
• Sulfamylpiperazines and method of preparing the same
  申请人：AMERICAN CYANAMID CO

  公开号：US02748129A1

  公开（公告）日：1956-05-29
• US9951086B2
  申请人：——

  公开号：US9951086B2

  公开（公告）日：2018-04-24
• [EN] PIPERAZINE DERIVATIVES AS HIV PROTEASE INHIBITORS<br/>[FR] DÉRIVÉS DE PIPÉRAZINE UTILISÉS EN TANT QU'INHIBITEURS DE LA PROTÉASE DU VIH
  申请人：MERCK SHARP & DOHME

  公开号：WO2015017393A2

  公开（公告）日：2015-02-05

  The present invention is directed to piperazine derivatives, pharmaceutical compositions comprising the same, and their use in the inhibition of HIV protease, the inhibition of HIV replication, the prophylaxis of infection by HIV, the treatment of infection by HIV, and the prophylaxis, treatment, and delay in the onset or progression of AIDS.