N,N'-benzene-1,2-diylbis(3-chlorobenzamide)

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N,N'-benzene-1,2-diylbis(3-chlorobenzamide)
• 英文别名: 3-chloro-N-[2-[(3-chlorobenzoyl)amino]phenyl]benzamide
• 化学式: C₂₀H₁₄Cl₂N₂O₂
• 分子量: 385.2
• InChiKey: GSSGCGPLOMFZQE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  26
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  58.2
• 氢给体数：
  2
• 氢受体数：
  2

文献信息

• Compound Combinations for Attenuation of Bacterial Virulence
  申请人：WISCONSIN ALUMNI RESEARCH FOUNDATION

  公开号：US20170231962A1

  公开（公告）日：2017-08-17

  Methods for modulating quorum sensing in certain Gram-negative bacteria having multiple QS systems including Las, Rhl, and Pqs with associated receptors (LasR, RhlR and PqsR) which are modulated by small molecule modulators, particularly non-native modulators. Certain combinations of modulators of Las, Rhl and Pqs exhibit improved inhibition of virulence in comparison to the respective individual modulators. In particular, certain combinations of modulators exhibit improved inhibition in nutritionally depleted environments. More specifically, certain combinations of modulators exhibit improved inhibition in environments depleted in phosphate and/or environments depleted in iron. Nutrient depleted environments can mimic environments associated with bacterial infection in humans and non-human animals. The methods are useful in particular for modulating QS in Pseudomonas and Buckholderia.

  在某些具有多个QS系统的革兰氏阴性细菌中，包括具有相关受体（LasR、RhlR和PqsR）的Las、Rhl和Pqs的调控方法，这些受体受小分子调节剂（尤其是非天然调节剂）的调节。Las、Rhl和Pqs的某些调节剂组合相比于各自的单个调节剂表现出对毒力的改善抑制。特别是，某些调节剂组合在营养匮乏环境中表现出改善的抑制作用。更具体地说，某些调节剂组合在缺乏磷酸盐和/或缺乏铁的环境中表现出改善的抑制作用。营养匮乏环境可以模拟与人类和非人类动物细菌感染相关的环境。这些方法特别适用于调节假单胞菌和布氏杆菌中的QS。
• Compound combinations for attenuation of bacterial virulence
  申请人：WISCONSIN ALUMNI RESEARCH FOUNDATION

  公开号：US10322112B2

  公开（公告）日：2019-06-18

  Methods for modulating quorum sensing in certain Gram-negative bacteria having multiple QS systems including Las, Rhl, and Pqs with associated receptors (LasR, RhlR and PqsR) which are modulated by small molecule modulators, particularly non-native modulators. Certain combinations of modulators of Las, Rhl and Pqs exhibit improved inhibition of virulence in comparison to the respective individual modulators. In particular, certain combinations of modulators exhibit improved inhibition in nutritionally depleted environments. More specifically, certain combinations of modulators exhibit improved inhibition in environments depleted in phosphate and/or environments depleted in iron. Nutrient depleted environments can mimic environments associated with bacterial infection in humans and non-human animals. The methods are useful in particular for modulating QS in Pseudomonas and Burkholderia.

  用于调节某些革兰氏阴性细菌法定人数感应的方法，这些细菌具有多个 QS 系统，包括 Las、Rhl 和 Pqs 以及相关的受体（LasR、RhlR 和 PqsR），这些受体受小分子调节剂，特别是非本地调节剂的调节。与单独的调节剂相比，Las、Rhl 和 Pqs 的某些调节剂组合能更好地抑制毒力。特别是，某些调制剂组合在营养缺乏的环境中表现出更好的抑制作用。更具体地说，某些调节剂组合在缺乏磷酸盐和/或缺乏铁的环境中表现出更好的抑制作用。营养缺乏的环境可以模拟与人类和非人类动物细菌感染有关的环境。这些方法尤其适用于调节假单胞菌和伯克霍尔德氏菌的 QS。
• Slippery liquid-infused porous surfaces that prevent microbial surface fouling
  申请人：Wisconsin Alumni Research Foundation

  公开号：US10557042B2

  公开（公告）日：2020-02-11

  The present invention provides polymer-based slippery liquid-infused porous surfaces (SLIPS) that can prevent adhesion and colonization by fungal and bacterial pathogens and also kill and/or attenuate the colonization and virulence of non-adherent pathogens in surrounding media. The present approach exploits the polymer and liquid oil phases in these slippery materials to sustain the release of small molecules such as a broad-spectrum antimicrobial agent, an antifungal agent, an antibacterial agent, an agent that modulates bacterial or fungal quorum sensing, an agent that attenuates virulence, or a combination thereof. This controlled release approach improves the inherent anti-fouling properties of SLIPS, has the potential to be general in scope, and expands the potential utility of slippery, non-fouling surfaces in both fundamental and applied contexts.

  本发明提供的聚合物基滑溜液体注入多孔表面（SLIPS）可以防止真菌和细菌病原体的粘附和定植，还可以杀死和/或减弱非粘附病原体在周围介质中的定植和毒力。本方法利用这些滑溜材料中的聚合物和液态油相来持续释放小分子，如广谱抗微生物剂、抗真菌剂、抗菌剂、调节细菌或真菌法定量感应的制剂、减弱毒性的制剂或其组合。这种可控释放方法改善了 SLIPS 固有的防污特性，具有通用性，并扩大了滑溜防污表面在基础和应用领域的潜在用途。
• Patient interface
  申请人：KONINKLIJKE PHILIPS N.V.

  公开号：US10751495B2

  公开（公告）日：2020-08-25

  The present invention relates to patient interfaces optically indicating a user that a member of the patient interface needs to be replaced due to wear. In particular, the present invention relates to a member for patient interface which includes at least one functional material having a predefined functionality and at least one indicator wherein the concentration of the at least one indicator in the member correlates with the predefined functionality of the at least one functional material.

  本发明涉及病人界面，通过光学方式向用户指示病人界面的部件因磨损而需要更换。特别是，本发明涉及一种病人界面部件，它包括至少一种具有预定功能的功能材料和至少一种指示器，其中部件中至少一种指示器的浓度与至少一种功能材料的预定功能相关。
• Quorum Sensing Modulators
  申请人：Muh Ute

  公开号：US20080287546A1

  公开（公告）日：2008-11-20

  Compounds described herein are useful in modulating bacterial quorum sensing.