6-(Tri-fluoroacetamido)-1-hexanoicanilide

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 6-(Tri-fluoroacetamido)-1-hexanoicanilide
• 英文别名: N-phenyl-6-[(2,2,2-trifluoroacetyl)amino]hexanamide
• 化学式: C₁₄H₁₇F₃N₂O₂
• 分子量: 302.29
• InChiKey: QLJFBJIGTNGCFE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  21
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  58.2
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• Non-Invasive Molecular Imaging of Cellular Histone Deacetylase Substrate Using Magnetic Resonance Spectroscopy (MRS) or Positron Emission Tomography (PET)
  申请人：Ronen Sabrina

  公开号：US20100278730A1

  公开（公告）日：2010-11-04

  We disclose methods of detecting histone deacetylase activity in a mammal by administering to the mammal a compound comprising at least one atom having a nucleus detectable by magnetic resonance spectroscopy, wherein the compound is a substrate of histone deacetylase; and observing the compound or a cleavage product thereof in at least a portion of the body of the mammal by magnetic resonance spectroscopy (MRS). We also disclose methods of detecting histone deacetylase activity in a mammal by administering to the mammal a compound comprising at least one positron-emission-decaying radioisotope, wherein the compound is a substrate of histone deacetylase; and observing the compound or a cleavage product thereof in at least a portion of the body of the mammal by positron emission tomography (PET). We also disclose compounds useful as histone deacetylase substrates.
• [EN] NON-INVASIVE MOLECULAR IMAGING OF CELLULAR HISTONE DEACETYLASE SUBSTRATE USING MAGNETIC RESONANCE SPECTROSCOPY (MRS) OR POSITRON EMISSION TOMOGRAPHY (PET)<br/>[FR] IMAGERIE MOLÉCULAIRE NON INVASIVE DE SUBSTRAT CELLULAIRE D'HISTONE DÉACÉTYLASE AU MOYEN DE LA SPECTROSCOPIE PAR RÉSONANCE MAGNÉTIQUE (SRM) OU DE LA TOMOGRAPHIE PAR ÉMISSION DE POSITRONS (TEP)
  申请人：UNIV TEXAS

  公开号：WO2009009179A2

  公开（公告）日：2009-01-15

  We disclose methods of detecting histone deacetylase activity in a mammal by administering to the mammal a compound comprising at least one atom having a nucleus detectable by magnetic resonance spectroscopy, wherein the compound is a substrate of histone deacetylase; and observing the compound or a cleavage product thereof in at least a portion of the body of the mammal by magnetic resonance spectroscopy (MRS). We also disclose methods of detecting histone deacetylase activity in a mammal by administering to the mammal a compound comprising at least one positron-emission-decaying radioisotope, wherein the compound is a substrate of histone deacetylase; and observing the compound or a cleavage product thereof in at least a portion of the body of the mammal by positron emission tomography (PET). We also disclose compounds useful as histone deacetylase substrates.