16:0 PDP-PE | 87707-01-5

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 甘油磷脂
• 英文名称: 16:0 PDP-PE
• 英文别名: N-[3-(2-pyridylthio)propionyl]-1,2-dipalmitoyl-sn-glycero-phosphoethanolamine；[(2R)-2-hexadecanoyloxy-3-[hydroxy-[2-[3-(pyridin-2-yldisulfanyl)propanoylamino]ethoxy]phosphoryl]oxypropyl] hexadecanoate
• CAS: 87707-01-5
• 化学式: C₄₅H₈₁N₂O₉PS₂
• 分子量: 889.252
• InChiKey: FKHHBNZLKDHJAH-VQJSHJPSSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  14.2
• 重原子数：
  59
• 可旋转键数：
  45
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.82
• 拓扑面积：
  201
• 氢给体数：
  2
• 氢受体数：
  12

反应信息

• 作为反应物：
  描述：

  Arg-Arg-Arg-Arg-Arg-Cys 、 16:0 PDP-PE 以 甲醇 、 氯仿 、 水 为溶剂， 反应 3.0h， 以10%的产率得到
  参考文献：
  名称：

  POLYCATIONIZED PHOSPHOLIPID DERIVATIVES

  摘要：

  本发明提供了新颖的磷脂衍生物。此外，本发明提供了在细胞内具有出色的基因/核酸引入效率的脂质膜结构。

  公开号：

  US20100094020A1
• 作为产物：
  描述：

  3-(2-吡啶基二硫基)丙酸N-羟基琥珀酰亚胺酯 、 L-磷脂酰乙醇胺 在 三乙胺 作用下， 以 氯仿 为溶剂， 反应 21.0h， 以88%的产率得到16:0 PDP-PE
  参考文献：
  名称：

  POLYCATIONIZED PHOSPHOLIPID DERIVATIVES

  摘要：

  本发明提供了新颖的磷脂衍生物。此外，本发明提供了在细胞内具有出色的基因/核酸引入效率的脂质膜结构。

  公开号：

  US20100094020A1

文献信息

• Synthetic nanostructures including nucleic acids and/or other entities
  申请人：Northwestern University

  公开号：US11285106B2

  公开（公告）日：2022-03-29

  Articles, compositions, kits, and methods relating to nanostructures, including synthetic nanostructures, are provided. Certain embodiments described herein include structures having a core-shell type arrangement; for instance, a nanostructure core may surrounded by a shell including a material, such as a lipid bilayer, and may include other components such as oligonucleotides. In some embodiments, the structures, when introduced into a subject, can be used to deliver nucleic acids and/or can regulate gene expression. Accordingly, the structures described herein may be used to diagnose, prevent, treat or manage certain diseases or bodily conditions. In some cases, the structures are both a therapeutic agent and a diagnostic agent.

  提供了与纳米结构（包括合成纳米结构）有关的物品、组合物、试剂盒和方法。本文所述的某些实施方案包括具有核壳型排列的结构；例如，纳米结构核可被包括材料（如脂质双分子层）的壳包围，并可包括其他成分（如寡核苷酸）。在某些实施方案中，将这些结构引入受试者体内后，可用于递送核酸和/或调节基因表达。因此，本文所述结构可用于诊断、预防、治疗或控制某些疾病或身体状况。在某些情况下，这些结构既是治疗剂又是诊断剂。
• WO2008/91655
  申请人：——

  公开号：——

  公开（公告）日：——
• A Quantitative Assessment of the Influence of Permanent Kinks on the Mixing Behavior of Phospholipids in Cholesterol-Rich Bilayers
  作者：Bingwen Jing、Nobuya Tokutake、Donald H. McCullough、Steven L. Regen

  DOI：10.1021/ja044517c

  日期：2004.12.1

  The mixing behavior of a phospholipid containing a cis-cyclopropyl moiety (1) with one that contains two myristoyl groups (3a) has been investigated in fluid bilayers via the nearest-neighbor recognition (NNR) method. In the absence of cholesterol, these lipids mix ideally. In the presence of cholesterol, they show a modest preference for homo-phospholipid association. A trans-form of 1 (i.e., 2) was found to have similar behavior, except that the influence of cholesterol in promoting homo-phospholipid association was greater. Similar results have been found in membranes in which 3a is replaced with a phospholipid bearing two palmitoyol chains (3b). In this case, the effect of the kink is approximately twice as great. The implications of these findings, with respect to the "trans-fatty acid debate", are briefly discussed
• NANOSTRUCTURES SUITABLE FOR SEQUESTERING CHOLESTEROL
  申请人：North Western University

  公开号：EP2288336B1

  公开（公告）日：2016-12-07
• POLYCATIONIZED PHOSPHOLIPID DERIVATIVES
  申请人：DEWA Takehisa

  公开号：US20100094020A1

  公开（公告）日：2010-04-15

  The present invention provides novel phospholipid derivatives. Furthermore, the present invention provides lipid membrane structures excellent in gene/nucleic acid introduction efficiency into a cell.

  本发明提供了新颖的磷脂衍生物。此外，本发明提供了在细胞内具有出色的基因/核酸引入效率的脂质膜结构。