2-[4-(hydroxymethyl)phenoxy]-N-[(4-methylphenyl)-phenylmethyl]acetamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-[4-(hydroxymethyl)phenoxy]-N-[(4-methylphenyl)-phenylmethyl]acetamide
• 化学式: C₂₃H₂₃NO₃
• 分子量: 361.4
• InChiKey: LZVZMJJRJMVEPO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  27
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  58.6
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• TETRAZINES/TRANS-CYCLOOCTENES IN SOLID PHASE SYNTHESIS OF LABELED PEPTIDES
  申请人：MEMORIAL SLOAN-KETTERING CANCER CENTER

  公开号：US20150359913A1

  公开（公告）日：2015-12-17

  This invention is in the field of labeled peptide construction for medical treatment and analysis. The invention relates to synthetic labeled peptide compositions, methods of synthesis, and methods of use for the synthetic labeled peptide compositions for medical treatment, imaging, and research purposes.

  这项发明涉及用于医疗治疗和分析的标记肽构建领域。该发明涉及合成标记肽组合物、合成方法以及用于医疗治疗、成像和研究目的的合成标记肽组合物的使用方法。
• [EN] PEPTIDE CONJUGATES, CONJUGATION PROCESS, AND USES THEREOF<br/>[FR] CONJUGUÉS PEPTIDIQUES, PROCÉDÉ DE CONJUGAISON, ET LEURS UTILISATIONS
  申请人：AUCKLAND UNISERVICES LTD

  公开号：WO2019043604A1

  公开（公告）日：2019-03-07

  The invention relates to peptide conjugates, methods for making peptide conjugates, conjugates produced by the methods, and pharmaceutical compositions comprising the conjugates. Methods of eliciting immune responses in a subject and methods of vaccinating a subject, uses of the conjugates for the same, and uses of the conjugates in the manufacture of medicaments for the same are also contemplated.

  本发明涉及肽缀合物、制备肽缀合物的方法、通过这些方法产生的缀合物以及包含这些缀合物的药物组合物。还考虑了在受试者中引发免疫反应的方法、给受试者接种疫苗的方法、缀合物用于相同目的的用途，以及缀合物在制造用于相同目的的药物中的用途。
• [EN] AMINO ACID AND PEPTIDE CONJUGATES AND USES THEREOF<br/>[FR] CONJUGUÉS D'ACIDES AMINÉS ET DE PEPTIDES ET LEURS UTILISATIONS
  申请人：BRIMBLE MARGARET ANNE

  公开号：WO2016103192A1

  公开（公告）日：2016-06-30

  The present invention relates to peptides, and amino acid and peptide conjugates, methods for making amino acid and peptide conjugates, conjugates produced by the methods, pharmaceutical compositions comprising the peptides and conjugates, methods of eliciting immune responses in a subject and methods of vaccinating a subject, uses of the peptides and conjugates for the same, and uses of the peptides and conjugates in the manufacture of medicaments for the same.

  本发明涉及肽、氨基酸和肽共轭物，制备氨基酸和肽共轭物的方法，通过这些方法生产的共轭物，包含这些肽和共轭物的药物组合物，在受试者中引发免疫反应的方法和给受试者接种疫苗的方法，这些肽和共轭物的用途以及这些肽和共轭物用于制造相同药物的用途。
• Long lasting fusion peptide inhibitors for hiv infection
  申请人：ConjuChem, Inc.

  公开号：EP1479691A1

  公开（公告）日：2004-11-24

  The present invention relates to C34 peptide derivatives that are inhibitors of viral infection and/or exhibit antifusogenic properties. In particular, this invention relates to C34 derivatives having inhibiting activity against human immunodeficiency virus (HIV), respiratory syncytial virus (RSV), human parainfluenza virus (HPV), measles virus (MeV), and simian immunodeficiency virus (SIV) with long duration of action for the treatment of the respective viral infections.

  本发明涉及 C34 肽衍生物，它们是病毒感染的抑制剂和/或具有抗致病性。特别是，本发明涉及对人类免疫缺陷病毒（HIV）、呼吸道合胞病毒（RSV）、人类副流感病毒（HPV）、麻疹病毒（MeV）和猿免疫缺陷病毒（SIV）具有抑制活性且作用时间长的 C34 衍生物，可用于治疗相应的病毒感染。
• Microwave-assisted peptide synthesis
  申请人：CEM Corporation

  公开号：EP1533025A2

  公开（公告）日：2005-05-25

  A vessel system for accelerating the solid phase synthesis of peptides comprises a vessel system for the accelerated synthesis of peptides by the solid phase method, said vessel system comprising: a reaction cell or vessel (45) that is transparent to microwave radiation; a first passageway (46) in fluid communication with said cell (45) for transferring solid phase resin between a resin source external to said cell and said cell; a second passageway (47) in fluid communication between at least one amino acid source and said cell (45) for adding amino acids to said cell; a third passageway (50) in gaseous communication with an inert gas source (70) and with a vent (71) for applying gas pressure to and releasing gas pressure from said cell (45) so that the controlled flow of gases to and from said cell can be used to add and remove fluids and flowing solids to and from said cell (45).

  一种用于加速多肽固相合成的容器系统，包括一个用于通过固相方法加速合成多肽的容器系统，所述容器系统包括： 对微波辐射透明的反应池或容器 (45) 与反应池（45）流体连通的第一通道（46），用于在反应池外部的树脂源和反应池之间传输固相树脂； 第二通道（47），与至少一个氨基酸源和所述样品池（45）流体连通，用于向所述样品池添加氨基酸； 第三通道 (50) 与惰性气体源 (70) 和排气口 (71) 气体连通，用于向所述样品池 (45) 施加气体压力和从所述样品池 (45) 释放气体压力，以便利用进出所述样品池的受控气体流向所述样品池 (45) 添加和移除流体和流动固体。