diethyl 7-fluoro-3-phenyl-2-(phenylsulfonamido)-1,2-dihydroisoquinolin-1-ylphosphonate | 1176334-85-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: diethyl 7-fluoro-3-phenyl-2-(phenylsulfonamido)-1,2-dihydroisoquinolin-1-ylphosphonate
• 英文别名: N-(1-diethoxyphosphoryl-7-fluoro-3-phenyl-1H-isoquinolin-2-yl)benzenesulfonamide
• CAS: 1176334-85-2
• 化学式: C₂₅H₂₆FN₂O₅PS
• 分子量: 516.53
• InChiKey: XJMAVDJBGBZLDM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.4
• 重原子数：
  35
• 可旋转键数：
  9
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  93.3
• 氢给体数：
  1
• 氢受体数：
  8

反应信息

• 作为产物：
  描述：

  N-[[5-fluoro-2-(2-phenylethynyl)phenyl]methylideneamino]benzenesulfonamide 、 亚磷酸二乙酯 在 palladium diacetate 作用下， 以 甲苯 为溶剂， 以70%的产率得到diethyl 7-fluoro-3-phenyl-2-(phenylsulfonamido)-1,2-dihydroisoquinolin-1-ylphosphonate
  参考文献：
  名称：

  Lewis acid-catalyzed reactions of N′-(2-alkynylbenzylidene)hydrazides with diethyl phosphite

  摘要：

  Lewis acid catalyst-tuned reactions of N'-(2-alkynylbenzylidene)hydrazides with diethyl phosphite are described. Isoquinolin-1-ylphosphonate is generated when copper triflate is utilized as catalyst, while 2-amino-1,2-dihydroisoquinolin-1-ylphosphonate is obtained in the presence of palladium acetate. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2009.05.013

文献信息

• Lewis acid-catalyzed reactions of N′-(2-alkynylbenzylidene)hydrazides with diethyl phosphite
  作者：Xingxin Yu、Qiuping Ding、Zhiyuan Chen、Jie Wu

  DOI：10.1016/j.tetlet.2009.05.013

  日期：2009.7

  Lewis acid catalyst-tuned reactions of N'-(2-alkynylbenzylidene)hydrazides with diethyl phosphite are described. Isoquinolin-1-ylphosphonate is generated when copper triflate is utilized as catalyst, while 2-amino-1,2-dihydroisoquinolin-1-ylphosphonate is obtained in the presence of palladium acetate. (C) 2009 Elsevier Ltd. All rights reserved.