1-butylcyclohexyl dibenzyl phosphate | 1133062-80-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-butylcyclohexyl dibenzyl phosphate
• 英文别名: [(1-Butylcyclohexyl)oxy-oxido-phenylmethoxyphosphaniumyl]oxymethylbenzene；[(1-butylcyclohexyl)oxy-oxido-phenylmethoxyphosphaniumyl]oxymethylbenzene
• CAS: 1133062-80-2
• 化学式: C₂₄H₃₃O₄P
• 分子量: 416.497
• InChiKey: ATENFVSUUZUJDS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.9
• 重原子数：
  29
• 可旋转键数：
  11
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  50.8
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  1-正-丁基环己醇 、 二苄基二乙基胺基膦 在 四氮唑 、 异氰酸苯酯 、 双氧水 作用下， 以 二氯甲烷 、 乙腈 、 水 为溶剂， 反应 17.0h， 以68%的产率得到1-butylcyclohexyl dibenzyl phosphate
  参考文献：
  名称：

  Efficient catalyst turnover in the phosphitylation of alcohols with phosphoramidites

  摘要：

  We report a method for catalytic phosphitylation utilizing phosphoramidites. Traditionally, this reaction is inefficient unless an excess of catalyst is present due to catalyst deactivation by an amine by-product. Isocyanate additives have been evaluated for scavenging the amine to facilitate catalyst turnover. A variety of alcohols and phosphoramidites were screened with 5 mol % catalyst. In the presence of additive, 83-97% conversion was achieved in contrast to 7-31% conversion without additive. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2008.12.065

文献信息

• Efficient catalyst turnover in the phosphitylation of alcohols with phosphoramidites
  作者：Patrick B. Brady、Elizabeth M. Morris、Owen S. Fenton、Bianca R. Sculimbrene

  DOI：10.1016/j.tetlet.2008.12.065

  日期：2009.3

  We report a method for catalytic phosphitylation utilizing phosphoramidites. Traditionally, this reaction is inefficient unless an excess of catalyst is present due to catalyst deactivation by an amine by-product. Isocyanate additives have been evaluated for scavenging the amine to facilitate catalyst turnover. A variety of alcohols and phosphoramidites were screened with 5 mol % catalyst. In the presence of additive, 83-97% conversion was achieved in contrast to 7-31% conversion without additive. (C) 2008 Elsevier Ltd. All rights reserved.