Pyridin-2-ylmethyl-thiazol-2-yl-amine | 757885-02-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: Pyridin-2-ylmethyl-thiazol-2-yl-amine
• 英文别名: Pyridylthiazolylaminomethane；N-(pyridin-2-ylmethyl)-1,3-thiazol-2-amine
• CAS: 757885-02-2
• 化学式: C₉H₉N₃S
• mdl: MFCD11119215
• 分子量: 191.257
• InChiKey: VSEIGLQZSAJZBJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  13
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.111
• 拓扑面积：
  66
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  Pyridin-2-ylmethyl-thiazol-2-yl-amine 以 1,4-二氧六环 、 甲苯 为溶剂， 生成 N-Pyridin-2-ylmethyl-N-[5-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethyl-ethyl)-thiazol-2-yl]-isobutyramide
  参考文献：
  名称：

  Heteroaryl substituted bis-trifluoromethyl carbinols as malonyl-CoA decarboxylase inhibitors

  摘要：

  A series of heteroaryl-substituted bis-trifluoromethyl carbinols were prepared and evaluated as malonyl-CoA decarboxylase (MCD) inhibitors. Some thiazole-based derivatives showed potent in vitro MCD inhibitory activities and significantly increased glucose oxidation rates in isolated working rat hearts. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2006.03.100
• 作为产物：
  描述：

  N-[(2-pyridyl)methylidene]-2-aminothiazole 在 sodium tetrahydroborate 作用下， 以 甲醇 为溶剂， 生成 Pyridin-2-ylmethyl-thiazol-2-yl-amine
  参考文献：
  名称：

  Heteroaryl substituted bis-trifluoromethyl carbinols as malonyl-CoA decarboxylase inhibitors

  摘要：

  A series of heteroaryl-substituted bis-trifluoromethyl carbinols were prepared and evaluated as malonyl-CoA decarboxylase (MCD) inhibitors. Some thiazole-based derivatives showed potent in vitro MCD inhibitory activities and significantly increased glucose oxidation rates in isolated working rat hearts. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2006.03.100

文献信息

• [EN] IMIDAZOPYRIDINE AND IMIDAZOPYRAZINE COMPOUNDS USEFUL AS KINASE INHIBITORS<br/>[FR] COMPOSÉS D'IMIDAZOPYRIDINE ET D'IMIDAZOPYRAZINE UTILISÉS COMME INHIBITEURS DE KINASE
  申请人：BRISTOL MYERS SQUIBB CO

  公开号：WO2009155388A1

  公开（公告）日：2009-12-23

  A compound of Formula (I) or Formula (II) and enantiomers, diastereomers and pharmaceutically-acceptable salts thereof. Also disclosed are pharmaceutical compositions containing compounds of Formula (I) or Formula (II), and methods of treating conditions associated with the activity of p38 kinase.

  一种由化合物（I）或化合物（II）及其对映体、二对映体和药学上可接受的盐组成的复合物。还公开了含有化合物（I）或化合物（II）的药物组合物，以及治疗与p38激酶活性相关疾病的方法。
• [EN] TRIAZOLOPYRIDINE COMPOUNDS USEFUL AS KINASE INHIBITORS<br/>[FR] COMPOSÉS DE TRIAZOLOPYRIDINE UTILISÉS COMME INHIBITEURS DE KINASE
  申请人：BRISTOL MYERS SQUIBB CO

  公开号：WO2009155389A1

  公开（公告）日：2009-12-23

  A compound of Formula (I) and enantiomers, diastereomers and pharmaceutically-acceptable salts thereof. Also disclosed are pharmaceutical compositions containing compounds of Formula (I), and methods of treating conditions associated with the activity of p38 kinase.

  一种由式（I）的化合物及其对映体、二对映体和药用可接受的盐组成的混合物。还公开了含有式（I）化合物的药物组合物，以及治疗与p38激酶活性相关疾病的方法。
• Heteroaryl substituted bis-trifluoromethyl carbinols as malonyl-CoA decarboxylase inhibitors
  作者：Jie-Fei Cheng、Chi Ching Mak、Yujin Huang、Richard Penuliar、Masahiro Nishimoto、Lin Zhang、Mi Chen、David Wallace、Thomas Arrhenius、Donald Chu、Guang Yang、Miguel Barbosa、Rick Barr、Jason R.B. Dyck、Gary D. Lopaschuk、Alex M. Nadzan

  DOI：10.1016/j.bmcl.2006.03.100

  日期：2006.7

  A series of heteroaryl-substituted bis-trifluoromethyl carbinols were prepared and evaluated as malonyl-CoA decarboxylase (MCD) inhibitors. Some thiazole-based derivatives showed potent in vitro MCD inhibitory activities and significantly increased glucose oxidation rates in isolated working rat hearts. (c) 2006 Elsevier Ltd. All rights reserved.