N,N-二甲基组胺 | 673-46-1

• 分子结构分类: 有机化合物 - 有机氮化合物
• 中文名称: N,N-二甲基组胺
• 英文名称: [2-(1H-Imidazol-4-yl)-ethyl]-dimethyl-amine
• 英文别名: N_α,N_α-dimethylhistamine；N^α,N^α-Dimethylhistamine；Nα,Nα-dimethyl-histamine；[2-(1(3)H-imidazol-4-yl)-ethyl]-dimethyl-amine；[2-(1(3)H-Imidazol-4-yl)-aethyl]-dimethyl-amin；Dimethyl-2-ethylamin；N,N-Dimethylhistamine；2-(1H-imidazol-5-yl)-N,N-dimethylethanamine
• CAS: 673-46-1
• 化学式: C₇H₁₃N₃
• mdl: MFCD01721568
• 分子量: 139.2
• InChiKey: ZJDIMSMQXMWMCF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.3
• 重原子数：
  10
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.571
• 拓扑面积：
  31.9
• 氢给体数：
  1
• 氢受体数：
  2

安全信息

• 海关编码：
  2933290090

反应信息

• 作为反应物：
  描述：

  N,N-二甲基组胺 在 碳酸氢钠 、 chlorothionoformate 作用下， 以 四氢呋喃 、 水 为溶剂， 以12%的产率得到5-(2-(dimethylamino)ethyl)-1H-imidazole-2-thiol
  参考文献：
  名称：

  EP2151447

  摘要：

  公开号：
• 作为产物：
  描述：

  1-hydroxybut-3-en-2-one 生成 N,N-二甲基组胺
  参考文献：
  名称：

  Studies of Imidazole Compounds. V. A New and Improved Synthesis of 4-(2-Substituted Aminoethyl)-imidazoles

  摘要：

  DOI：

  10.1021/ja01154a052

文献信息

• Direct Copper(III) Formation from O₂ and Copper(I) with Histamine Ligation
  作者：J. Brannon Gary、Cooper Citek、Timothy A. Brown、Richard N. Zare、Erik C. Wasinger、T. Daniel P. Stack

  DOI：10.1021/jacs.6b05538

  日期：2016.8.10

  the oxygenation of histamine-ligated copper(I) complexes is demonstrated here, indicating that copper(III) is a viable oxidation state in such products from both kinetic and thermodynamic perspectives. At low temperatures, both trinuclear Cu(II)2Cu(III)O2 and dinuclear Cu(III)2O2 predominate, with the distribution dependent on the histamine ligand structure and oxygenation conditions. Kinetics studies

  铜羟基化酶中的末端组氨酸残基对铜 (I) 的组胺螯合激活分子氧以形成未知的氧化剂，通常假定为铜 (II) 物质。这里展示了组胺连接的铜 (I) 复合物氧化直接形成含铜 (III) 的产物，表明从动力学和热力学角度来看，铜 (III) 在此类产物中是一种可行的氧化态。在低温下，三核 Cu(II)2Cu(III)O2 和双核 Cu(III)2O2 占主导地位，其分布取决于组胺配体结构和氧化条件。动力学研究表明，这两种产品的分叉点是一种未观察到的过氧化物水平的二聚体中间体。三核和双核复合物在组胺配体对等时的氢原子反应性差异是惊人的。这种行为最好归因于桥接氧化物配体对外源底物的可及性，而不是簇的氧化能力差异。
• LINCOMYCIN DERIVATIVES AND ANTIMICROBIAL AGENTS COMPRISING THE SAME AS ACTIVE INGREDIENT
  申请人：Wakiyama Yoshinari

  公开号：US20100210570A1

  公开（公告）日：2010-08-19

  An objective of the present invention is to provide compounds of formula (1) or their pharmacologically acceptable salts or solvates wherein A represents aryl; R 1 represents N-optionally substituted C 1-6 alkyl-N-optionally substituted C 1-6 alkylamino-C 1-6 alkyl; R 2 represents a hydrogen atom or optionally substituted C 1-6 alkyl; R 3 represents optionally substituted C 1-6 alkyl or C 3-6 cycloalkyl-C 1-4 alkyl; m is 1 to 3; n is 0; and p is 0 to 2. The compounds are novel lincomycin derivatives that have a potent activity against resistant Streptococcus pneumoniae, which have recently posed problems, in the treatment of infectious diseases. Further, the compounds are usable as antimicrobial agents and are useful for preventing or treating bacterial infectious diseases.

  本发明的目标是提供以下化合物(1)或其药理学上可接受的盐或溶剂，其中A代表芳基；R1代表N-可选取代的C1-6烷基-N-可选取代的C1-6烷基氨基-C1-6烷基；R2代表氢原子或可选取代的C1-6烷基；R3代表可选取代的C1-6烷基或C3-6环烷基-C1-4烷基；m为1至3；n为0；p为0至2。这些化合物是新颖的林可霉素衍生物，对最近在感染性疾病治疗中引起问题的耐药性肺炎链球菌具有强效活性。此外，这些化合物可用作抗微生物药物，有助于预防或治疗细菌感染性疾病。
• Capture compounds, collections thereof and methods for analyzing the proteome and complex compositions
  申请人：Köster Hubert

  公开号：US20110118136A1

  公开（公告）日：2011-05-19

  Capture compounds and collections thereof and methods using the compounds for the analysis of biomolecules are provided. In particular, collections, compounds and methods are provided for analyzing complex protein mixtures, such as the proteome. The compounds are multifunctional reagents that provide for the separation and isolation of complex protein mixtures. Each compound has the formula: wherein: Z is a trityl derivative; X, the reactivity function, covalently binds to amino acid side chains of proteins; Y, the selectivity function, modulates binding of X to the amino acid side chains in proteins such that X binds to fewer proteins when Y is present than in its absence; and Q permits separation or immobilization of the capture compound. Automated systems for performing the methods also are provided.

  本文提供了捕获化合物和化合物集合以及使用这些化合物进行生物分子分析的方法。特别地，提供了用于分析复杂蛋白质混合物（如蛋白质组）的集合、化合物和方法。这些化合物是多功能试剂，可用于分离和分离复杂蛋白质混合物。每个化合物的公式为：其中：Z是三苯甲基衍生物；X是反应性功能，共价结合到蛋白质的氨基酸侧链上；Y是选择性功能，调节X与蛋白质中氨基酸侧链的结合，使得在Y存在时，X与较少的蛋白质结合，而在Y不存在时，X与更多的蛋白质结合；Q允许分离或固定捕获化合物。本文还提供了用于执行这些方法的自动化系统。
• Compositions comprising a mast cell degranulation-blocking agent for treatment of endogenous, painful gastrointestinal conditions of non-inflammatory, non-ulcerative origin.
  申请人：KOS PHARMACEUTICALS, INC.

  公开号：EP1203586A2

  公开（公告）日：2002-05-08

  A method for treating endogenous, painful gastrointestinal condition of non-inflammatory, non-ulcerative origin, such as abdominal migraine and irritable bowel syndrome, entails administering a pharmacologically effective amount of a mast cell degranulation-blocking agent, e.g. a histamine-3 receptor agonist.

  一种治疗非炎症性、非溃疡性内源性胃肠道疼痛病症（如腹型偏头痛和肠易激综合征）的方法，需要给药有效量的肥大细胞脱颗粒阻断剂，如组胺-3 受体激动剂。
• LINCOMYCIN DERIVATIVES AND ANTIBACTERIAL AGENTS CONTAINING THE SAME AS THE ACTIVE INGREDIENT
  申请人：Meiji Seika Kaisha Ltd.

  公开号：EP2151447A1

  公开（公告）日：2010-02-10

  An objective of the present invention is to provide compounds of formula (1) or their pharmacologically acceptable salts or solvates wherein A represents aryl; R1 represents N-optionally substituted C1-6 alkyl-N-optionally substituted C1-6 alkylamino-C1-6 alkyl; R2 represents a hydrogen atom or optionally substituted C1-6 alkyl; R3 represents optionally substituted C1-6alkyl or C3-6 cycloalkyl-C1-4 alkyl; m is 1 to 3; n is 0; and p is 0 to 2. The compounds are novel lincomycin derivatives that have a potent activity against resistant Streptococcus pneumoniae, which have recently posed problems, in the treatment of infectious diseases. Further, the compounds are usable as antimicrobial agents and are useful for preventing or treating bacterial infectious diseases.

  本发明的目的是提供式（1）化合物或其药理学上可接受的盐或溶液，其中 A 代表芳基；R1 代表 N-任选取代的 C1-6 烷基-N-任选取代的 C1-6 烷基氨基-C1-6 烷基；R2 代表氢原子或任选取代的 C1-6 烷基；R3 代表任选取代的 C1-6 烷基或 C3-6 环烷基-C1-4 烷基；m 为 1 至 3；n 为 0；p 为 0 至 2。这些化合物是新型的林可霉素衍生物，在治疗传染性疾病方面对耐药性肺炎链球菌有很强的活性，而耐药性肺炎链球菌近来已造成了一些问题。此外，这些化合物还可用作抗菌剂，用于预防或治疗细菌性传染病。

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