N-(4-{[3-(4-Methylbenzenesulfonamido)quinoxalin-2-YL]amino}phenyl)acetamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-(4-{[3-(4-Methylbenzenesulfonamido)quinoxalin-2-YL]amino}phenyl)acetamide
• 英文别名: N-[4-[[3-[(4-methylphenyl)sulfonylamino]quinoxalin-2-yl]amino]phenyl]acetamide
• 化学式: C₂₃H₂₁N₅O₃S
• mdl: MFCD00324522
• 分子量: 447.5
• InChiKey: YCSQUMADCPEGTB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  32
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  122
• 氢给体数：
  3
• 氢受体数：
  7

文献信息

• [EN] IDENTIFICATION OF STABILIZERS OF MULTIMERIC PROTEINS<br/>[FR] IDENTIFICATION DE STABILISANTS DE PROTÉINES MULTIMÉRIQUES
  申请人：UNIV LELAND STANFORD JUNIOR

  公开号：WO2011140333A1

  公开（公告）日：2011-11-10

  Disclosed herein are compounds and compositions thereof which find use in increasing stability of TTR tetramers reducing its tendency to misfold and form aggregates. Also provided herein are methods for using these compounds and compositions for increasing stability of TTR and therby decreasing aggegate formation by TTR. Also disclosed herein are methods to screen for candidate compounds that increase stability of TTR. Also disclosed herein are heterobifunctional compounds that include a TTR binding compound connected to a targeting moiety via a linker, for use in disrupting PPIs of a target protein.

  本文披露了一些化合物及其组合物，可用于增加TTR四聚体的稳定性，减少其错误折叠和形成聚集物的倾向。本文还提供了使用这些化合物和组合物来增加TTR稳定性并从而减少TTR聚集物形成的方法。本文还披露了用于筛选增加TTR稳定性的候选化合物的方法。本文还披露了一种包括TTR结合化合物通过连接物连接到靶向基团的异双功能化合物，用于破坏靶蛋白的蛋白-蛋白相互作用。
• Methods of Using PI3K and MEK Modulators
  申请人：Aftab Dana T.

  公开号：US20100075947A1

  公开（公告）日：2010-03-25

  The invention provides methods of treating cancer with a combination of compounds which inhibit kinases, more specifically MEK and PI3K.

  本发明提供了一种使用抑制激酶的化合物组合来治疗癌症的方法，更具体地说是抑制MEK和PI3K的化合物组合。
• Phosphatidylinositol 3-Kinase Inhibitors and Methods of Their Use
  申请人：Bajjalieh William

  公开号：US20100087440A1

  公开（公告）日：2010-04-08

  The present invention comprises small molecule inhibitors of phosphatidylinositol 3-kinase (PI3K), which is associated with a number of malignancies such as ovarian cancer, cervical cancer, breast cancer, colon cancer, rectal cancer, and glioblastomas, among others. Accordingly, the compounds of the present invention are useful for treating, preventing, and/or inhibiting these diseases.

  本发明涉及磷脂酰肌醇3-激酶（PI3K）的小分子抑制剂，该酶与多种恶性肿瘤相关，如卵巢癌、宫颈癌、乳腺癌、结肠癌、直肠癌和胶质母细胞瘤等。因此，本发明的化合物可用于治疗、预防和/或抑制这些疾病。
• Phosphatidylinositol 3-Kinase Inhibitors And Methods Of Their Use
  申请人：Bajjalieh William

  公开号：US20110207712A1

  公开（公告）日：2011-08-25

  The present invention comprises small molecule inhibitors of phosphatidylinositol 3-kinase (PI3K), which is associated with a number of malignancies such as ovarian cancer, cervical cancer, breast cancer, colon cancer, rectal cancer, and glioblastomas, among others. Accordingly, the compounds of the present invention are useful for treating, preventing, and/or inhibiting these diseases.

  本发明涉及磷脂酰肌醇3-激酶（PI3K）的小分子抑制剂，PI3K与多种恶性肿瘤相关，如卵巢癌、宫颈癌、乳腺癌、结肠癌、直肠癌和胶质母细胞瘤等。因此，本发明化合物可用于治疗、预防和/或抑制这些疾病。
• COMBINATION THERAPIES COMPRISING QUINOXALINE INHIBITORS OF P13K-ALPHA FOR USE IN THE TREATMENT OF CANCER
  申请人：Lamb Peter

  公开号：US20110123434A1

  公开（公告）日：2011-05-26

  The present invention provides methods of treating cancer by administering a compound of Formula I, optionally as a pharmaceutically acceptable salt, solvate and/or hydrate thereof, in combination with other cancer treatments.

  本发明提供了一种通过与其他癌症治疗方法联合使用的方法，给予I式化合物（可选地作为其药学上可接受的盐，溶剂和/或水合物）治疗癌症的方法。