N-(1,3-苯并二氧戊环-5-基甲基)环丙胺 | 643007-93-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并间二氧杂环戊烯类
• 中文名称: N-(1,3-苯并二氧戊环-5-基甲基)环丙胺
• 英文名称: N-(benzo[d][1,3]dioxol-5-ylmethyl)cyclopropanamine
• 英文别名: N-(1,3-benzodioxol-5-ylmethyl)cyclopropanamine
• CAS: 643007-93-6
• 化学式: C₁₁H₁₃NO₂
• mdl: MFCD07408138
• 分子量: 191.23
• InChiKey: HROUFMHZMXWOHI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  14
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.454
• 拓扑面积：
  30.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  N-(1,3-苯并二氧戊环-5-基甲基)环丙胺 在 sodium tungstate 、 双氧水 作用下， 以 甲醇 、 水 为溶剂， 生成 1-(1,3-benzodioxol-5-yl)-N-cyclopropylmethanimine oxide
  参考文献：
  名称：

  Synthesis of C-Aryl-N-cyclopropylnitrones

  摘要：

  Synthesis of C-aryl-N-cyclopropylnitrones is described. Preparations were performed either by condensation of the appropriate aldehyde with N-cyclopropyl-hydroxylamine, or oxidation of N-substituted N-cyclopropylamines with sodium tungstate/hydrogen peroxide.

  DOI：

  10.1081/scc-120024001
• 作为产物：
  描述：

  [1-Benzo[1,3]dioxol-5-yl-meth-(Z)-ylidene]-cyclopropyl-amine 在 sodium tetrahydroborate 作用下， 以 甲醇 为溶剂， 生成 N-(1,3-苯并二氧戊环-5-基甲基)环丙胺
  参考文献：
  名称：

  Synthesis of C-Aryl-N-cyclopropylnitrones

  摘要：

  Synthesis of C-aryl-N-cyclopropylnitrones is described. Preparations were performed either by condensation of the appropriate aldehyde with N-cyclopropyl-hydroxylamine, or oxidation of N-substituted N-cyclopropylamines with sodium tungstate/hydrogen peroxide.

  DOI：

  10.1081/scc-120024001

文献信息

• NOVEL COMPOUNDS AS INHIBITORS OF RENIN
  申请人：Thombare Pravain

  公开号：US20120115907A1

  公开（公告）日：2012-05-10

  The present invention relates to novel renin inhibitors of general formula (1), novel intermediates involved in their synthesis, their pharmaceutically acceptable salts and pharmaceutical compositions containing them. The present invention also relates to a process of preparing compounds of general formula (1), their tautomeric forms, their pharmaceutically acceptable salts, pharmaceutical compositions containing them, and novel intermediates involved in their synthesis.

  本发明涉及一般式（1）的新型肾素抑制剂，其合成中涉及的新型中间体，它们的药用盐以及含有它们的药物组合物。本发明还涉及制备一般式（1）化合物的方法，它们的互变异构体形式，它们的药用盐，含有它们的药物组合物，以及合成中涉及的新型中间体。
• 7-ARYL-3,9-DIAZABICYCLO[3.3.1]NON-6-ENE DERIVATIVES AND THEIR USE AS RENIN INHIBITORS IN THE TREATMENT OF HYPERTENSION, CARDIOVASCULAR OR RENAL DISEASES
  申请人：Actelion Pharmaceuticals Ltd.

  公开号：EP1501830B1

  公开（公告）日：2011-10-05
• Synthesis of C-Aryl-N-cyclopropylnitrones
  作者：Vukics, Krisztina、Tarkanyi, Gabor、Dravecz, Ferenc、Fischer, Janos

  DOI：10.1081/scc-120024001

  日期：2003.9

  Synthesis of C-aryl-N-cyclopropylnitrones is described. Preparations were performed either by condensation of the appropriate aldehyde with N-cyclopropyl-hydroxylamine, or oxidation of N-substituted N-cyclopropylamines with sodium tungstate/hydrogen peroxide.