N-(1-氨基甲酰乙基)苯甲酰胺 | 24250-70-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: N-(1-氨基甲酰乙基)苯甲酰胺
• 英文名称: DL-N-benzoylalaninamide
• 英文别名: N-benzoyl-DL-alanine amide；N-benzoyl-alanine amide；N-Benzoyl-DL-alanin-amid；N-Benzoyl-alanin-amid；Benzoyl-dl-alanin-amid；(+/-)-2-Benzamino-propionsaeure-amid；Benzamide, N-(1-carbamoylethyl)-, DL-；N-(1-amino-1-oxopropan-2-yl)benzamide
• CAS: 24250-70-2
• 化学式: C₁₀H₁₂N₂O₂
• mdl: MFCD11643217
• 分子量: 192.217
• InChiKey: ZWDNWUISPPRMSS-UHFFFAOYSA-N

物化性质

• 熔点：
  231-233 °C
• 沸点：
  476.4±28.0 °C(Predicted)
• 密度：
  1.172±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.1
• 重原子数：
  14
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  72.2
• 氢给体数：
  2
• 氢受体数：
  2

安全信息

• 海关编码：
  2924299090

反应信息

• 作为反应物：
  描述：

  甲醇 、 N-(1-氨基甲酰乙基)苯甲酰胺 在 Amberlyst 15 作用下， 反应 24.0h， 以89%的产率得到methyl N-benzoylalaninate
  参考文献：
  名称：

  Mild conversion of carboxamides and carboxylic acid hydrazides to acids and esters

  摘要：

  DOI：

  10.1021/jo00339a019
• 作为产物：
  描述：

  N-Benzoylalanyl chloride 在 氨 作用下， 生成 N-(1-氨基甲酰乙基)苯甲酰胺
  参考文献：
  名称：

  Max, Justus Liebigs Annalen der Chemie, 1909, vol. 369, p. 282

  摘要：

  DOI：

文献信息

• PYRAZOLAMIDE COMPOUND HAVING INSECTICIDAL ACTIVITY AND USE THEREOF
  申请人：JIANGSU FLAG CHEMICAL INDUSTRY CO., LTD.

  公开号：US20200329707A1

  公开（公告）日：2020-10-22

  The present invention discloses a pyrazolamide compound of General Formula I having an insecticidal activity and an intermediate of General Formula II used to preparing the compound of General Formula I, wherein R 1 is selected from chloro or CN, R 2 is selected from H, C 1 -C 3 alkyl, C 1 -C 3 haloalkyl or C 1 -C 5 alkoxyalkyl, R 3 is selected from halo or C 1 -C 3 haloalkyl, R 4 is selected from halo, and R 5 is selected from H or halo. Compared with the compounds in the prior art, the compound of General Formula I of the present invention has a higher activity at a low concentration. This reduces the amount of the compound used and the residue of the compound in farmland, and is thus environmentally friendly.

  本发明公开了一种具有杀虫活性的一般式I的吡唑酰胺化合物，以及用于制备一般式I化合物的一般式II的中间体，其中R1选自氯或CN，R2选自H、C1-C3烷基、C1-C3卤代烷基或C1-C5烷氧基烷基，R3选自卤或C1-C3卤代烷基，R4选自卤，R5选自H或卤。与先前技术中的化合物相比，本发明的一般式I化合物在低浓度下具有更高的活性。这降低了化合物的使用量和在农田中的残留量，因此对环境更友好。
• PYRAZOLYL AMIDE COMPOUNDS AND USES THEREOF
  申请人：SHENYANG SINOCHEM AGROCHEMICALS R&D CO., LTD.

  公开号：US20160286806A1

  公开（公告）日：2016-10-06

  Disclosed is a pyrazole amide compound of a novel structure as represented by general formula I, wherein, each substituent group is as defined in the specification. The compound of general formula I has good insecticidal activity, and can be used for pest control.

  本发明揭示了一种新结构的吡唑酰胺化合物，其通式表示为I，其中每个取代基如规范中定义。通式I的化合物具有良好的杀虫活性，可用于害虫控制。
• Glycine-selective α-carbon-nitrogen bond cleavage of dipeptides by nickel peroxide
  作者：Christopher J. Easton、Sharon K. Eichinger、Michael J. Pitt

  DOI：10.1016/s0040-4020(97)00216-0

  日期：1997.4

  Nickel peroxide selectively cleaves the α-carbon-nitrogen bond of glycine residues in dipeptide derivatives to give the corresponding amides. The glycine selectivity is attributable to preferential complexation of the reactant residue to nickel peroxide and subsequent reaction via a stable α-centred glycyl radical. The oxidation process serves as a chemical model for peptidylglycine α-amidating monooxygenase

  过氧化镍选择性切割二肽衍生物中甘氨酸残基的α-碳-氮键，得到相应的酰胺。甘氨酸的选择性归因于反应物残基与过氧化镍的优先络合以及随后通过稳定的以α为中心的甘氨酰基自由基进行反应。氧化过程可作为肽基甘氨酸α-酰胺化单加氧酶（PAM）的化学模型，此外，它可能具有合成肽内α，β-二氢杂氨基酸残基的潜力。
• PYRAZOLE AMIDE COMPOUND AND APPLICATION THEREOF
  申请人：Shenyang Sinochem Agrochemicals R & D Co., Ltd.

  公开号：EP3075729A1

  公开（公告）日：2016-10-05

  Dischosed is a pyrazole amide compound of a novel structure as represented by general formula I, wherein, each substituent group is as defined in the specification. The compound of general formula I has good insecticidal activity, and can be used for pest control.

  本发明公开了一种结构新颖的吡唑酰胺化合物，由通式 I 表示，其中，每个取代基团如说明书中所定义。通式 I 的化合物具有良好的杀虫活性，可用于害虫防治。
• PYRAZOLE AMIDE COMPOUND HAVING PESTICIDAL ACTIVITY AND USE THEREOF
  申请人：Jiangsu Flag Chemical Industry Co., Ltd.

  公开号：EP3719011A1

  公开（公告）日：2020-10-07

  The present invention discloses a pyrazolamide compound of General Formula I having an insecticidal activity and an intermediate of General Formula II used to preparing the compound of General Formula I, wherein R1 is selected from chloro or CN, R2 is selected from H, C1-C3 alkyl, C1-C3 haloalkyl or C1-C5 alkoxyalkyl, R3 is selected from halo or C1-C3 haloalkyl, R4 is selected from halo, and R5 is selected from H or halo. Compared with the compounds in the prior art, the compound of General Formula I of the present invention has a higher activity at a low concentration. This reduces the amount of the compound used and the residue of the compound in farmland, and is thus environmentally friendly.

  本发明公开了一种具有杀虫活性的通式I的吡唑酰胺化合物和一种用于制备通式I化合物的通式II的中间体，其中R1选自氯或CN，R2选自H、C1-C3烷基、C1-C3卤代烷基或C1-C5烷氧基烷基，R3选自卤代或C1-C3卤代烷基，R4选自卤代，R5选自H或卤代。与现有技术中的化合物相比，本发明通式 I 的化合物在低浓度下具有更高的活性。这就减少了化合物的用量，降低了化合物在农田中的残留量，从而有利于环保。