4-(2-chloro-nicotinoylamino)-benzoic acid | 57842-03-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-(2-chloro-nicotinoylamino)-benzoic acid
• 英文别名: 4-{[(2-Chloropyridin-3-yl)carbonyl]amino}benzoic acid；4-[(2-chloropyridine-3-carbonyl)amino]benzoic acid
• CAS: 57842-03-2
• 化学式: C₁₃H₉ClN₂O₃
• mdl: MFCD02176790
• 分子量: 276.679
• InChiKey: RXQHKVGSIBYUAL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  19
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  79.3
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• NOVEL TRICYCLIC DERIVATIVE OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF, PREPARATION METHOD THEREOF, AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME
  申请人：Jeil Pharmaceutical Co., Ltd.

  公开号：EP2364983A2

  公开（公告）日：2011-09-14

  The present invention relates to a novel tricyclic derivative with efficient inhibitory activity against poly(ADP-ribose)polymerases (PARP) or pharmaceutically acceptable salts thereof, a preparation method thereof, and a pharmaceutical composition containing the same. The tricyclic derivative of the invention is useful for the prevention or treatment of diseases caused by excess PARP activity, especially neuropathic pain, neurodegenerative diseases, cardiovascular diseases, diabetic nephropathy, inflammatory diseases, osteoporosis, and cancer, by inhibiting the activity of poly(ADP-ribose)polymerases.

  本发明涉及一种对多（ADP-核糖）聚合酶（PARP）具有高效抑制活性的新型三环衍生物或其药学上可接受的盐、其制备方法以及含有该衍生物的药物组合物。本发明的三环衍生物通过抑制聚（ADP-核糖）聚合酶的活性，可用于预防或治疗由 PARP 活性过高引起的疾病，特别是神经性疼痛、神经退行性疾病、心血管疾病、糖尿病肾病、炎症性疾病、骨质疏松症和癌症。