1-(3-Fluorophenyl)-3-(2-methoxy-4-nitrophenyl)urea

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-(3-Fluorophenyl)-3-(2-methoxy-4-nitrophenyl)urea
• 化学式: C14H12FN3O4
• 分子量: 305.26
• InChiKey: QGCZIIHESBVSOZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  22
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  96.2
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• [EN] hTRPV1 CHEMICAL AGENTS<br/>[FR] AGENTS CHIMIQUES HTRPV1
  申请人：UNIV PITTSBURGH

  公开号：WO2016127085A1

  公开（公告）日：2016-08-11

  Novel diphenylurea and benzylbenzenesulfonamide compounds are disclosed along with methods of inhibiting the activity of TRPV1 and methods of treating pain associated with transient receptor potential vanilloid type 1 (TRPV1) using such compounds.

  本发明揭示了新型二苯脲和苄基苯磺酰胺化合物，以及使用这些化合物抑制TRPV1活性的方法和用于治疗与瞬时受体电位香草酰基转移酶1（TRPV1）相关的疼痛的方法。
• Cavity Induced Allosteric Modification Of Intermolecular Interactions And Methods Of Identifying Compounds That Effect The Same
  申请人：MURALI Ramachandran

  公开号：US20100151507A1

  公开（公告）日：2010-06-17

  Method of identifying compounds that modulate intermolecular interactions between a target protein and a modifier are disclosed. Pharmaceutical composition comprising compounds that inhibit intermolecular interactions between a target protein and a modifier are disclosed. Methods of treating individual suffering from inflammatory conditions, undesirable immune responses, immunological conditions and bacterial infections are disclosed.
• hTRPV1 CHEMICAL AGENTS
  申请人：UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION

  公开号：US20180215705A1

  公开（公告）日：2018-08-02

  Novel diphenylurea and benzylbenzenesulfonamide compounds are disclosed along with methods of inhibiting the activity of TRPV1 and methods of treating pain associated with transient receptor potential vanilloid type 1 (TRPV1) using such compounds.
• US7653495B1
  申请人：——

  公开号：US7653495B1

  公开（公告）日：2010-01-26
• US8019557B2
  申请人：——

  公开号：US8019557B2

  公开（公告）日：2011-09-13