5-methyl-thiophene-2-carboxylic acid (7-bromo-4-methoxy-benzothiazol-2-yl)-amide | 383865-40-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并噻唑类
• 英文名称: 5-methyl-thiophene-2-carboxylic acid (7-bromo-4-methoxy-benzothiazol-2-yl)-amide
• 英文别名: 5-Methyl-thiophene-2-carboxylic acid (7-bromo-4-methoxybenzothiazol-2-yl)-amide；N-(7-bromo-4-methoxy-1,3-benzothiazol-2-yl)-5-methylthiophene-2-carboxamide
• CAS: 383865-40-5
• 化学式: C₁₄H₁₁BrN₂O₂S₂
• 分子量: 383.29
• InChiKey: OVLHJFAGUNFFEY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  21
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  108
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  5-methyl-thiophene-2-carboxylic acid (7-bromo-4-methoxy-benzothiazol-2-yl)-amide 、 吡啶-4-硼酸 生成 5-methyl-thiophene-2-carboxylic acid (4-methoxy-7-pyridin-4-yl-benzothiazol-2-yl)-amide
  参考文献：
  名称：

  Benzothiazole derivatives with activity as adenosine receptor ligands

  摘要：

  本发明涉及替代苯并噻唑衍生物及其药学上可接受的盐，用于治疗与腺苷受体有关的疾病。

  公开号：

  US06835732B2
• 作为产物：
  描述：

  5-甲基噻吩-2-羰酰氯 、 7-bromo-4-methoxybenzo[d]thiazol-2-amine 在 吡啶 作用下， 以 二氯甲烷 为溶剂， 生成 5-methyl-thiophene-2-carboxylic acid (7-bromo-4-methoxy-benzothiazol-2-yl)-amide
  参考文献：
  名称：

  Benzothiazole derivatives with activity as adenosine receptor ligands

  摘要：

  本发明涉及替代苯并噻唑衍生物及其药用可接受的盐，用于治疗与腺苷受体相关的疾病。

  公开号：

  US20020045615A1

文献信息

• Benzothiazole derivatives with actitvity as adenosine receptor ligands
  申请人：Alanine Alexander

  公开号：US20050026906A1

  公开（公告）日：2005-02-03

  The present invention relates to substituted benzothiazole derivatives and to their pharmaceutically acceptable salts useful for the treatment of diseases related to the adenosine receptor.

  本发明涉及取代苯并噻唑衍生物及其药学上可接受的盐，用于治疗与腺苷受体相关的疾病。
• BENZOTHIAZOLE DERIVATIVES
  申请人：F. HOFFMANN-LA ROCHE AG

  公开号：EP1303272A2

  公开（公告）日：2003-04-23
• [EN] BENZOTHIAZOLE DERIVATIVES<br/>[FR] DERIVES DE BENZOTHIAZOLE
  申请人：HOFFMANN LA ROCHE

  公开号：WO2001097786A2

  公开（公告）日：2001-12-27

  The present invention relates to compounds of the general formula (I) and to their pharmaceutically acceptable salts for the treatment of diseases related to the adenosine A2 receptor, novel compounds of formula I-A per se,their manufacture, medicaments based on a compound in accordance with the invention and their production as well as the use of compounds of compounds of formula I in the control or prevention of illnesses based on the modulation of the adenosine system, such as Alzheimer's disease, Parkinson's disease, neuroprotection, schizophrenia, anxiety, pain, respiration deficits, depression, asthma, allergic responses hypoxia, ischaemia, seizure and substance abuse. Furthermore, compounds of the present invention may be useful as sedatives, muscle relaxants, antipsychotics, antiepileptics, anticonvulsants and cardiaprotective agents.
• Benzothiazole derivatives with activity as adenosine receptor ligands
  申请人：——

  公开号：US20020045615A1

  公开（公告）日：2002-04-18

  The present invention relates to substituted benzothiazole derivitives and to their pharmaceutically acceptable salts useful for the treatment of diseases related to the adenosine receptor.

  本发明涉及替代苯并噻唑衍生物及其药用可接受的盐，用于治疗与腺苷受体相关的疾病。
• BENZOTHIAZOLE DERIVATIVES WITH ACTIVITY AS ADENOSINE RECEPTOR LIGANDS
  申请人：Alanine Alexander

  公开号：US20080108809A1

  公开（公告）日：2008-05-08

  The present invention relates to substituted benzothiazole derivitives and to their pharmaceutically acceptable salts useful for the treatment of diseases related to the adenosine receptor.

  本发明涉及取代苯并噻唑衍生物及其药学上可接受的盐，用于治疗与腺苷受体相关的疾病。