N-(1-苯基乙基)-9H-嘌呤-6-胺 | 55553-54-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并嘧啶类
• 中文名称: N-(1-苯基乙基)-9H-嘌呤-6-胺
• 英文名称: N6-Phenaethyladenin
• 英文别名: (1-phenyl-ethyl)-(7(9)H-purin-6-yl)-amine；N-(1-Phenylethyl)-1H-purin-6-amine；N-(1-phenylethyl)-7H-purin-6-amine
• CAS: 55553-54-3
• 化学式: C₁₃H₁₃N₅
• mdl: MFCD11115303
• 分子量: 239.28
• InChiKey: OPBOKLRORBKBAN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  18
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.153
• 拓扑面积：
  66.5
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  α-苯乙胺 、 6-甲巯基嘌呤 生成 N-(1-苯基乙基)-9H-嘌呤-6-胺
  参考文献：
  名称：

  Syntheses of Kinetin-analogs. I

  摘要：

  DOI：

  10.1246/bcsj.30.194

文献信息

• [EN] COMPOUNDS FOR IMPROVING MRNA SPLICING<br/>[FR] COMPOSÉS POUR AMÉLIORER L'ÉPISSAGE DE L'ARNM
  申请人：GEN HOSPITAL CORP

  公开号：WO2016115434A1

  公开（公告）日：2016-07-21

  Provided herein are compounds useful for improving mRNA splicing in a cell. Exemplary compounds provided herein are useful for improving mRNA splicing in genes comprising at least one exon ending in the nucleotide sequence CAA. Methods for preparing the compounds and methods of treating diseases of the central nervous system are also provided.

  本文提供了一些有助于改善细胞内mRNA剪接的化合物。本文提供的示例化合物有助于改善包含至少一个以核苷酸序列CAA结尾的外显子的基因的mRNA剪接。还提供了制备这些化合物的方法以及治疗中枢神经系统疾病的方法。
• [EN] COMPOSITIONS AND METHODS OF USING THE SAME FOR TREATMENT OF NEURODEGENERATIVE AND MITOCHONDRIAL DISEASE<br/>[FR] COMPOSITIONS ET LEURS MÉTHODE D'UTILISATION POUR LE TRAITEMENT D'UNE MALADIE NEURODEGENERATIVE ET MITOCHONDRIALE
  申请人：MITOKININ INC

  公开号：WO2020206363A1

  公开（公告）日：2020-10-08

  The present disclosure is directed to nitrogen-containing heteroaryl analogs, methods of making nitrogen-containing analogs, and methods of treating disorders associated with PINK1 kinase activity including, but not limited to, neurodegenerative diseases, mitochondrial diseases, fibrosis, and/or cardiomyopathy using these analogs. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

  本公开涉及含氮杂环类似物，制备含氮类似物的方法，以及使用这些类似物治疗与PINK1激酶活性相关的疾病的方法，包括但不限于神经退行性疾病、线粒体疾病、纤维化和/或心肌病。本摘要旨在作为在特定领域进行搜索的扫描工具，并不打算限制本发明。
• Compounds for improving mRNA splicing
  申请人：The General Hospital Corporation

  公开号：US10676475B2

  公开（公告）日：2020-06-09

  Provided herein are compounds useful for improving mRNA splicing in a cell. Exemplary compounds provided herein are useful for improving mRNA splicing in genes comprising at least one exon ending in the nucleotide sequence CAA. Methods for preparing the compounds and methods of treating diseases of the central nervous system are also provided.

  本文提供的化合物有助于改善细胞中的 mRNA 剪接。本文提供的示例化合物可用于改善包含至少一个以核苷酸序列 CAA 结尾的外显子的基因中的 mRNA 剪接。还提供了制备这些化合物的方法和治疗中枢神经系统疾病的方法。
• Syntheses of 6-Substituted Purines
  作者：Milon W. Bullock、John J. Hand、E. L. R. Stokstad

  DOI：10.1021/ja01596a037

  日期：1956.8
• CELLULOSE ACYLATE FILM, RETARDATION FILM, POLARIZER AND LIQUID CRYSTAL DISPLAY DEVICE
  申请人：NAGURA MASATO

  公开号：US20110076423A1

  公开（公告）日：2011-03-31

  A cellulose acylate film comprising a cellulose acylate resin satisfying the formulae (i)-(iii) and a compound capable of forming a hydrogen bond satisfying conditions (A)-(C): (A) the compound has both a hydrogen bond donor moiety and a hydrogen bond acceptor moiety in the molecule, (B) the value obtained by dividing the molecular weight of the compound by the total of the number of the hydrogen bond donor moiety and the number of the hydrogen bond acceptor moiety is from 30 to 65, (C) the number of aromatic ring structures is from 1 to 3, 0.5≦ A+B ≦2.7,  (i) 0.0≦A≦2.5, and  (ii) 0.1≦B≦2.0,  (iii) wherein A means the degree of substitution with an acetyl group, and B means a total of the degree of substitution with a propionyl group and the degree of substitution with a butyryl group.