Tetramethyl dodecanedioyldiphosphonate | 148330-14-7

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机膦酸及其衍生物
• 英文名称: Tetramethyl dodecanedioyldiphosphonate
• 英文别名: Tetramethyl 1,12-dioxododecane-1,12-bisphosphonate；1,12-Bis(dimethoxyphosphoryl)dodecane-1,12-dione
• CAS: 148330-14-7
• 化学式: C₁₆H₃₂O₈P₂
• 分子量: 414.373
• InChiKey: WTQSPADTJXQKNO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  26
• 可旋转键数：
  17
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  105
• 氢给体数：
  0
• 氢受体数：
  8

反应信息

• 作为反应物：
  描述：

  Tetramethyl dodecanedioyldiphosphonate 在 磺酰氯 、 双氧水 、 碳酸氢钠 作用下， 以 乙醚 为溶剂， 反应 30.0h， 生成 2,11-二氯十二烷-1,12-二酸
  参考文献：
  名称：

  Use of acylphosphonates for the synthesis of α-chlorinated carboxylic and α,α′-dichloro dicarboxylic acids and their derivatives

  摘要：

  alpha -Chloro acylphosphonates and alpha,alpha'-dichloro bisacylphosphonates were prepared in situ by chlorination of acylphosphonates and bisacylphosphonates, respectively, using sulfuryl chloride. Subsequently, they were cleaved to the corresponding alpha -chlorinated or alpha,alpha'-dichlorinated (di)carboxylic acids with a hydrogen peroxide-sodium bicarbonate system. Performing the cleavage with an alcohol or an amine yielded the corresponding alpha -chlorinated esters and alpha -chlorinated amides, respectively. (C) 2001 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4020(01)00407-0
• 作为产物：
  描述：

  癸基二酰二氯 、 三甲氧基磷 反应 4.0h， 生成 Tetramethyl dodecanedioyldiphosphonate
  参考文献：
  名称：

  Use of acylphosphonates for the synthesis of α-chlorinated carboxylic and α,α′-dichloro dicarboxylic acids and their derivatives

  摘要：

  alpha -Chloro acylphosphonates and alpha,alpha'-dichloro bisacylphosphonates were prepared in situ by chlorination of acylphosphonates and bisacylphosphonates, respectively, using sulfuryl chloride. Subsequently, they were cleaved to the corresponding alpha -chlorinated or alpha,alpha'-dichlorinated (di)carboxylic acids with a hydrogen peroxide-sodium bicarbonate system. Performing the cleavage with an alcohol or an amine yielded the corresponding alpha -chlorinated esters and alpha -chlorinated amides, respectively. (C) 2001 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4020(01)00407-0

文献信息

• Use of acylphosphonates for the synthesis of α-chlorinated carboxylic and α,α′-dichloro dicarboxylic acids and their derivatives
  作者：Christian V Stevens、Bart Vanderhoydonck

  DOI：10.1016/s0040-4020(01)00407-0

  日期：2001.5

  alpha -Chloro acylphosphonates and alpha,alpha'-dichloro bisacylphosphonates were prepared in situ by chlorination of acylphosphonates and bisacylphosphonates, respectively, using sulfuryl chloride. Subsequently, they were cleaved to the corresponding alpha -chlorinated or alpha,alpha'-dichlorinated (di)carboxylic acids with a hydrogen peroxide-sodium bicarbonate system. Performing the cleavage with an alcohol or an amine yielded the corresponding alpha -chlorinated esters and alpha -chlorinated amides, respectively. (C) 2001 Elsevier Science Ltd. All rights reserved.