N-[4-(benzo[f]quinazolin-6'-ylamino)-3-methoxyphenyl]methanesulfonamide | 1272661-18-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: N-[4-(benzo[f]quinazolin-6'-ylamino)-3-methoxyphenyl]methanesulfonamide
• 英文别名: N-[4-(benzo[f]quinazolin-6-ylamino)-3-methoxyphenyl]methanesulfonamide
• CAS: 1272661-18-3
• 化学式: C₂₀H₁₈N₄O₃S
• 分子量: 394.454
• InChiKey: QFMOETMHHVUALR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  28
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  102
• 氢给体数：
  2
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  6-bromobenzo[f]quinazoline 、 N-(4-氨基-3-甲氧基苯基)甲磺酰胺 在 palladium diacetate 、 caesium carbonate 、 R-(+)-1,1'-联萘-2,2'-双二苯膦 作用下， 以 水 为溶剂， 反应 0.33h， 以12%的产率得到N-[4-(benzo[f]quinazolin-6'-ylamino)-3-methoxyphenyl]methanesulfonamide
  参考文献：
  名称：

  Benzoquinazoline derivatives as new agents affecting DNA processing

  摘要：

  A new series of benzo[h]quinazoline and benzo[f]quinazoline derivatives was prepared and studied for the biological activity. The compounds carrying a dimethylaminoethyl side chain (6c, 8c and 12) inhibit cell growth. The ability to form a molecular complex with DNA and to interfere with topoll and topol relaxation activity was evidenced for the most active 6c and 8c, along with the capacity to induce apoptosis on HeLa cells. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2010.12.037

文献信息

• Benzoquinazoline derivatives as new agents affecting DNA processing
  作者：Giovanni Marzaro、Lisa Dalla Via、Antonio Toninello、Adriano Guiotto、Adriana Chilin

  DOI：10.1016/j.bmc.2010.12.037

  日期：2011.2

  A new series of benzo[h]quinazoline and benzo[f]quinazoline derivatives was prepared and studied for the biological activity. The compounds carrying a dimethylaminoethyl side chain (6c, 8c and 12) inhibit cell growth. The ability to form a molecular complex with DNA and to interfere with topoll and topol relaxation activity was evidenced for the most active 6c and 8c, along with the capacity to induce apoptosis on HeLa cells. (C) 2010 Elsevier Ltd. All rights reserved.