N-(3-ethylphenyl)ethanesulfonamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-(3-ethylphenyl)ethanesulfonamide
• 化学式: C₁₀H₁₅NO₂S
• mdl: MFCD01344806
• 分子量: 213.3
• InChiKey: LKKSUBJTWLXAMW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  14
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  54.6
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• [EN] PYRAZOLE DERIVATIVES, COMPOSITIONS AND THERAPEUTIC USE THEREOF<br/>[FR] DÉRIVÉS DE PYRAZOLE, COMPOSITIONS LES COMPRENANT ET LEUR UTILISATION THÉRAPEUTIQUE
  申请人：HOFFMANN LA ROCHE

  公开号：WO2017191098A1

  公开（公告）日：2017-11-09

  Compounds of Formula (I): and salts thereof, and methods of use as Janus kinase inhibitors are described herein.

  化合物的化学式（I）及其盐，以及作为Janus激酶抑制剂的使用方法在此处描述。
• Thrombin receptor antagonists
  申请人：——

  公开号：US20040152736A1

  公开（公告）日：2004-08-05

  A series of compounds represented by the structural formulas 1 2 and pharmaceutically acceptable isomers, salts, solvates and polymorphs thereof are disclosed. Also disclosed are pharmaceutical compositions containing said compounds and their use as thrombin receptor antagonists and binders to cannabinoid receptors.

  本文披露了一系列化合物，其结构式表示为12，并且包括其药学上可接受的异构体、盐、溶剂合物和多晶形式。还披露了含有这些化合物的制药组合物，并将其用作凝血酶受体拮抗剂和大麻素受体结合剂。
• BROMODOMAIN INHIBITORS
  申请人：Quanticel Pharmaceuticals, Inc.

  公开号：US20150183784A1

  公开（公告）日：2015-07-02

  The present invention relates to substituted heterocyclic derivative compounds, compositions comprising said compounds, and the use of said compounds and compositions for epigenetic regulation by inhibition of bromodomain-mediated recognition of acetyl lysine regions of proteins, such as histones. Said compositions and methods are useful for the treatment of cancer and neoplastic disease.

  本发明涉及替代杂环衍生物化合物、包含该化合物的组合物以及利用该化合物和组合物通过抑制溴域介导的蛋白质乙酰赖氨酸区域的识别进行表观遗传调控的用途，例如组蛋白。所述组合物和方法对于治疗癌症和肿瘤疾病有用。
• 2-HYDROXY-1-{4-[(4-PHENYLPHENYL)CARBONYL]PIPERAZIN-1-YL}ETHAN-1-ONE DERIVATIVES AND RELATED COMPOUNDS AS FATTY ACID SYNTHASE (FASN) INHIBITORS FOR THE TREATMENT OF CANCER
  申请人：Forma Therapeutics, Inc.

  公开号：EP2968316B1

  公开（公告）日：2019-08-07
• PYRAZOLE DERIVATIVES, COMPOSITIONS AND THERAPEUTIC USE THEREOF
  申请人：F. Hoffmann-La Roche AG

  公开号：EP3452464B1

  公开（公告）日：2021-12-15