tert-butyl N-bromo-N-(2-bromo-3-phenylpropyl)carbamate | 358365-94-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: tert-butyl N-bromo-N-(2-bromo-3-phenylpropyl)carbamate
• CAS: 358365-94-3
• 化学式: C₁₄H₁₉Br₂NO₂
• 分子量: 393.118
• InChiKey: XFYIUNDBALQXDF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  19
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  29.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  tert-butyl N-bromo-N-(2-bromo-3-phenylpropyl)carbamate 在 水 、 sodium sulfite 作用下， 生成 (2-Bromo-3-phenyl-propyl)-carbamic acid tert-butyl ester
  参考文献：
  名称：

  t-Butyl N,N-dibromocarbamate (BBC)—new reagent for aminobromination of terminal alkenes

  摘要：

  t-Butyl N,N-dibromocarbamate, easily obtained by bromination of t-butyl carbamate in aqueous potassium carbonate, reacts smoothly with a variety of terminal alkenes to afford the corresponding beta -bromo-N-Boc-amines upon reduction with aqueous sodium sulphite. Immediate deprotection of N-Boc-amines with gaseous HCl yields beta -bromoamine hydrochlorides in good yields. (C) 2001 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(01)00662-1
• 作为产物：
  描述：

  氨基甲酸叔丁酯 在 溴 、 potassium carbonate 作用下， 以 二氯甲烷 、 水 为溶剂， 反应 2.0h， 生成 tert-butyl N-bromo-N-(2-bromo-3-phenylpropyl)carbamate
  参考文献：
  名称：

  t-Butyl N,N-dibromocarbamate (BBC)—new reagent for aminobromination of terminal alkenes

  摘要：

  t-Butyl N,N-dibromocarbamate, easily obtained by bromination of t-butyl carbamate in aqueous potassium carbonate, reacts smoothly with a variety of terminal alkenes to afford the corresponding beta -bromo-N-Boc-amines upon reduction with aqueous sodium sulphite. Immediate deprotection of N-Boc-amines with gaseous HCl yields beta -bromoamine hydrochlorides in good yields. (C) 2001 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(01)00662-1

文献信息

• t-Butyl N,N-dibromocarbamate (BBC)—new reagent for aminobromination of terminal alkenes
  作者：Anna Klepacz、Andrzej Zwierzak

  DOI：10.1016/s0040-4039(01)00662-1

  日期：2001.7

  t-Butyl N,N-dibromocarbamate, easily obtained by bromination of t-butyl carbamate in aqueous potassium carbonate, reacts smoothly with a variety of terminal alkenes to afford the corresponding beta -bromo-N-Boc-amines upon reduction with aqueous sodium sulphite. Immediate deprotection of N-Boc-amines with gaseous HCl yields beta -bromoamine hydrochlorides in good yields. (C) 2001 Elsevier Science Ltd. All rights reserved.