2,3-Dimethyl-4-(3-hydroxypropylthio)pyridine-N-oxide | 162279-98-3

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫醚类
• 英文名称: 2,3-Dimethyl-4-(3-hydroxypropylthio)pyridine-N-oxide
• 英文别名: 2,3-Dimethyl-4-(3-hydroxypropylthio)pyridine N-oxide；3-(2,3-dimethyl-1-oxidopyridin-1-ium-4-yl)sulfanylpropan-1-ol
• CAS: 162279-98-3
• 化学式: C₁₀H₁₅NO₂S
• 分子量: 213.301
• InChiKey: PRZYPHUJWYKZCU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  14
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  71
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  2,3-二甲基-4-氯吡啶-N-氧化物 、 3-巯基-1-丙醇 以 N-甲基吡咯烷酮 、 水 为溶剂， 以68%的产率得到2,3-Dimethyl-4-(3-hydroxypropylthio)pyridine-N-oxide
  参考文献：
  名称：

  Substituted arylalkylthioalkylthiopyridines for use in the control of

  摘要：

  一种化学式为I ##STR1## 的化合物，其中所有变量在规范中有定义。这些化合物用于控制幽门螺杆菌。

  公开号：

  US05859030A1

文献信息

• Pyridylthio compounds for controlling helicobacter bacteria
  申请人：Byk Gulden Lomberg Chemische Fabrik GmbH

  公开号：US06162809A1

  公开（公告）日：2000-12-19

  Pyridinylthiomethyl- and pyrimidinylthiomethyl-pyridines and their pharmacologically-acceptable compositions are useful for controlling Helicobacter bacteria and for treating those afflicted with diseases based on Helicobacter bacteria.

  吡啶硫甲基和嘧啶硫甲基吡啶及其药用可接受的组合物可用于控制幽门螺杆菌并治疗患有基于幽门螺杆菌引起的疾病的患者。
• Piperazinothiopyridines for the control of Helicobacter bacteria
  申请人：Byk Gulden Lomberg Chemische Fabrik GmbH

  公开号：US05922720A1

  公开（公告）日：1999-07-13

  Compounds of formula I are piperazinothiopyridines which are useful for controlling Helicobacter bacteria. They are useful as active compounds for treating diseases based on such bacteria, and are thus useful for making appropriate medicament compositions for administering to humans afflicted with diseases based on or caused by such bacteria.

  式I的化合物是对控制幽门螺杆菌有用的哌嗪硫吡啶类化合物。它们可作为治疗基于该细菌的疾病的活性化合物，并且因此可用于制备适当的药物组合物，用于给予患有基于或由该细菌引起的疾病的人类。
• Preparation of substituted pyridine N-oxide compounds
  申请人：——

  公开号：US20040063957A1

  公开（公告）日：2004-04-01

  A process for preparing substituted pyridine N-oxide compounds of the formula 1 in which R1, R2, R3 and R4 are each H, a carboxyl group or a C 1 -C 12 -alkyl radical which may contain atoms from the group of N, O and S, or R1 and R2 and/or R3 and R4 together may each form an optionally substituted C 4 -C 20 -alkylene radical which may contain atoms from the group of N, O and S, A is benzyl or a (CH 2 ) m group where m may be an integer from 1 to 12, Z 1 and Z 2 are each independently O or S, and Y is H, a C 1 -C 12 -alkyl radical which may optionally contain atoms from the group of N, O and S, a C 6 -C 20 -aryl radical or a C 5 -C 20 -heterocycle, and the radicals may optionally be substituted, or Z 2 and Y together form an optionally substituted ring or ring system, in which case the ring or ring system may contain atoms from the group of N, O and S, from the corresponding 4-halopyridine N-oxide of the formula 2 in which X is chlorine, bromine or iodine, by reacting the compound of the formula (II), in the presence of a phase transfer catalyst and of a base, with a compound of the formula HZ 1 -A-Z 2 -Y  (III) in which Z 1 , Z 2 , A and Y are each as defined above, at a temperature up to the reflux temperature, to give the corresponding substituted pyridine N-oxide compound of the formula (I), and also a process for preparing the compound of the formula (II).

  一种制备取代吡啶N-氧化物化合物的方法，该化合物的公式为1，其中R1、R2、R3和R4分别为H、羧基或可能含有N、O和S的C1-C12烷基基团，或者R1和R2和/或R3和R4可以共同形成一个可选取代的C4-C20烷基基团，该基团可能含有N、O和S的原子，A为苄基或(CH2)m基团，其中m可以是1到12的整数，Z1和Z2各自独立地为O或S，Y为H、C1-C12烷基基团，该基团可以选择地含有N、O和S的原子，C6-C20芳基基团或C5-C20杂环，且基团可以选择性地被取代，或者Z2和Y共同形成一个可选择性取代的环或环系统，此时该环或环系统可以含有N、O和S的原子，从公式2中相应的4-卤代吡啶N-氧化物开始，其中X为氯、溴或碘，通过在相转移催化剂和碱存在下，将公式（II）的化合物与公式HZ1-A-Z2-Y（III）的化合物在回流温度以下的温度下反应，从而得到公式（I）的相应取代吡啶N-氧化物化合物，以及制备公式（II）的化合物的方法。
• Substituted arylthioalkylthiopyridines
  申请人：BYK Gulden Lomberg Chemische Fabrik GmbH

  公开号：US05773451A1

  公开（公告）日：1998-06-30

  Described are compounds of formula (I) in which R1,R2,R3,R4,R5,R6,R7, m,n,p, and q are as defined in the description. Such compounds are suitable for use against Helicobacter bacteria. ##STR1##

  本文描述的是式（I）的化合物，其中R1，R2，R3，R4，R5，R6，R7，m，n，p和q如描述中所定义。这些化合物适用于对抗幽门螺杆菌。## STR1 ##
• US5773451A
  申请人：——

  公开号：US5773451A

  公开（公告）日：1998-06-30