(E)-1,2,4,5-tetrafluoro-3-methoxy-6-styrylbenzene | 862013-69-2

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二苯乙烯类
• 英文名称: (E)-1,2,4,5-tetrafluoro-3-methoxy-6-styrylbenzene
• 英文别名: 1,2,4,5-tetrafluoro-3-methoxy-6-[(E)-2-phenylethenyl]benzene
• CAS: 862013-69-2
• 化学式: C₁₅H₁₀F₄O
• 分子量: 282.237
• InChiKey: IPQSBHCRWGQFMV-BQYQJAHWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  20
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  苯乙烯 、 2,3,5,6-四氟茴香醚 在 silver carbonate 、 茴香硫醚 、 palladium diacetate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 9.0h， 以84%的产率得到(E)-1,2,4,5-tetrafluoro-3-methoxy-6-styrylbenzene
  参考文献：
  名称：

  Thioether-Promoted Direct Olefination of Polyfluoroarenes Catalyzed by Palladium

  摘要：

  A methyl(phenyl)sulfane-promoted direct olefination of polyfluoroarenes catalyzed by palladium has been reported. With use of this new thioether ligand, a high reaction efficiency and excellent E/Z ratio of desired olefinated polyfluoroarenes were obtained. This represents a first example of thioether promoted oxidative Heck reaction.

  DOI：

  10.1021/ol402492s

文献信息

• Pd(OAc)₂ Catalyzed Olefination of Highly Electron-Deficient Perfluoroarenes
  作者：Xingang Zhang、Shilu Fan、Chun-Yang He、Xiaolong Wan、Qiao-Qiao Min、Jie Yang、Zhong-Xing Jiang

  DOI：10.1021/ja908434e

  日期：2010.4.7

  An efficient, Pd(OAc)(2) catalyzed method for direct olefination of highly electron-deficient perfluoroarenes was developed. The reaction scope includes a series of activated and nonactivated alkenes in moderate to high yields with moderate to high regio- and stereoselectivities.
• Thioether-Promoted Direct Olefination of Polyfluoroarenes Catalyzed by Palladium
  作者：Cai-Zhi Wu、Chun-Yang He、Yangen Huang、Xingang Zhang

  DOI：10.1021/ol402492s

  日期：2013.10.18

  A methyl(phenyl)sulfane-promoted direct olefination of polyfluoroarenes catalyzed by palladium has been reported. With use of this new thioether ligand, a high reaction efficiency and excellent E/Z ratio of desired olefinated polyfluoroarenes were obtained. This represents a first example of thioether promoted oxidative Heck reaction.