N-(2-氨乙基)-N’-[2-(1-哌嗪基)乙基]-1,2-乙二胺 | 31295-49-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 中文名称: N-(2-氨乙基)-N’-[2-(1-哌嗪基)乙基]-1,2-乙二胺
• 中文别名: N-(2-氨乙基)-N'-[2-(1-哌嗪基)乙基]-1,2-乙二胺
• 英文名称: N-(2-aminoethyl)-N'-[2-(1-piperazinyl)ethyl]ethylenediamine
• 英文别名: N-(2-Aminoethyl)-N'-(2-(1-piperazinyl)ethyl)ethylenediamine；N'-[2-(2-piperazin-1-ylethylamino)ethyl]ethane-1,2-diamine
• CAS: 31295-49-5
• 化学式: C₁₀H₂₅N₅
• 分子量: 215.342
• InChiKey: LPOUQGUYVMSQOH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.2
• 重原子数：
  15
• 可旋转键数：
  8
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  65.4
• 氢给体数：
  4
• 氢受体数：
  5

安全信息

• 危险等级：
  8
• 海关编码：
  2933599090
• 包装等级：
  III
• 危险品运输编号：
  UN 2735

反应信息

• 作为产物：
  描述：

  哌嗪 、 N1-[2-(1-氮丙啶基)乙基]-1,2-乙二胺 在 氢气 作用下， 以 水 为溶剂， 生成 N-(2-氨乙基)-N’-[2-(1-哌嗪基)乙基]-1,2-乙二胺
  参考文献：
  名称：

  Bobylev, V. A.; Dalin, A. R.; Borisenko, I. V., Journal of general chemistry of the USSR, 1989, vol. 59, # 5.2, p. 1003 - 1007

  摘要：

  DOI：

文献信息

• NOVEL METHOD FOR PRODUCING TETA BY MEANS OF EDDN
  申请人：Dahmen Kirsten

  公开号：US20100121064A1

  公开（公告）日：2010-05-13

  The invention relates to a process for preparing triethylenetetramine (TETA), which, comprises the following steps: a) reaction of ethylenediamine (EDA) with formaldehyde and hydrocyanic acid (HCN) in a molar ratio of EDA to formaldehyde to HCN of from 1:1.5:1.5 to 1:2:2 to give ethylenediaminediacetonitrile (EDDN), b) hydrogenation of the EDDN obtained in step a) in the presence of a catalyst and a solvent.

  这项发明涉及一种制备三乙烯四胺（TETA）的过程，包括以下步骤：a）乙二胺（EDA）与甲醛和氰化氢（HCN）按照乙二胺与甲醛与氰化氢的摩尔比为1:1.5:1.5至1:2:2反应，得到乙二胺二乙腈（EDDN），b）在存在催化剂和溶剂的情况下氢化步骤a）中得到的EDDN。
• [EN] PROCESS FOR MANUFACTURING A CYCLIC UREA ADDUCT OF AN ETHYLENEAMINE COMPOUND<br/>[FR] PROCÉDÉ DE FABRICATION DE PRODUIT D'ADDITION D'URÉE CYCLIQUE D'UN COMPOSÉ ÉTHYLÈNEAMINE
  申请人：AKZO NOBEL CHEMICALS INT BV

  公开号：WO2019030191A1

  公开（公告）日：2019-02-14

  The invention pertains to a process for manufacturing a cyclic urea adduct of an ethyleneamine compound, the ethyleneamine compound having a linear -NH-CH2-CH2-NH- group, the process comprising the steps of - in an absorption step contacting a liquid medium comprising an ethyleneamine compound having a linear -NH-CH2-CH2-NH- group with a CO2-containing gas stream at a pressure of 1 -20 bara, resulting in the formation of a liquid medium into which CO2 has been absorbed, - bringing the liquid medium to cyclic urea formation conditions, and in an urea formation step forming cyclic urea adduct of the ethyleneamine compound, urea formation conditions including a temperature of at least 120°C, wherein the total pressure at the end of the urea formation step is at most 20 bara, wherein the temperature in the absorption step is lower than the temperature in the urea formation step. It has been found that the process according to the invention makes it possible to obtain cyclic urea adducts in an efficient manner in the absence of metal-containing catalysts and to perform the process under relatively mild conditions, in particular relatively low pressure. More specifically, by separating the CO2 absorption step from the urea formation step, the CO2 absorption step can be carried out at relatively low temperatures and pressures. And because the CO2 is already present in the system at the beginning of the urea formation step, the pressure in the urea formation step does not need to be high.

  该发明涉及一种制造具有线性-NH-CH2-CH2-NH-基团的乙二胺化合物的环式脲加合物的工艺，该工艺包括以下步骤：-在吸收步骤中，将包含具有线性-NH-CH2-CH2-NH-基团的乙二胺化合物的液体介质与含CO2气流在1-20 bara的压力下接触，导致形成已吸收CO2的液体介质，-将液体介质带到环式脲形成条件，并在脲形成步骤中形成乙二胺化合物的环式脲加合物，脲形成条件包括至少120°C的温度，在脲形成步骤结束时的总压力最多为20 bara，在吸收步骤中的温度低于脲形成步骤中的温度。发现该发明的工艺使得在无金属催化剂的情况下以相对温和的条件，特别是相对低压下有效地获得环式脲加合物成为可能。更具体地，通过将CO2吸收步骤与脲形成步骤分离，CO2吸收步骤可以在相对低温和压力下进行。由于在脲形成步骤开始时系统中已经存在CO2，因此脲形成步骤中的压力不需要很高。
• AMINOALCOHOL LIPIDOIDS AND USES THEREOF
  申请人：Mahon Kerry Peter

  公开号：US20110293703A1

  公开（公告）日：2011-12-01

  Aminoalcohol lipidoids are prepared by reacting an amine with an epoxide-terminated compound are described. Methods of preparing aminoalcohol lipidoids from commercially available starting materials are also provided. Aminoalcohol lipidoids may be prepared from racemic or stereochemically pure epoxides. Aminoalcohol lipidoids or salts forms thereof are preferably biodegradable and biocompatible and may be used in a variety of drug delivery systems. Given the amino moiety of these aminoalcohol lipidoid compounds, they are particularly suited for the delivery of polynucleotides. Complexes, micelles, liposomes or particles containing the inventive lipidoids and polynucleotide have been prepared. The inventive lipidoids may also be used in preparing microparticles for drug delivery. They are particularly useful in delivering labile agents given their ability to buffer the pH of their surroundings.

  本文描述了通过将胺与环氧末端化合物反应制备氨基醇脂质体的方法。还提供了从商业起始材料制备氨基醇脂质体的方法。氨基醇脂质体可以从外消旋或立体化学纯的环氧化合物制备。氨基醇脂质体或其盐形式最好是可生物降解和生物相容的，并可用于各种药物输送系统。鉴于这些氨基醇脂质体化合物的氨基基团，它们特别适用于多核苷酸的输送。已经制备了包含创新脂质体和多核苷酸的复合物、胶束、脂质体或粒子。创新脂质体也可以用于制备药物输送的微粒。鉴于它们能够缓冲其周围环境的pH值，它们在输送不稳定剂方面特别有用。
• Stable, aqueous dispersions of polyurethane-ureas and coatings and films prepared therefrom
  申请人：BAYER AG

  公开号：EP0148970A2

  公开（公告）日：1985-07-24

  The present invention relates to a stable, aqueous dispersion of polyurethane-ureas wherein said polyurethane-ureas contain i) about 2 to 200 milliequivalents per 100 grams of polyurethane-urea of chemically incorporated anionic groups, and ii) up to about 15% by weight, based on the weight of the polyurethane-urea, of lateral and/or terminal hydrophilic chains containing ethylene oxide units, wherein the counterions of the anionic groups are a mixture of volatile and non-volatile cations in an equivalent ratio of about 1:10 to 10:1. The present invention is also directed to the coatings and films prepared from these dispersions.

  本发明涉及一种稳定的聚氨酯-尿素水分散体，其中所述聚氨酯-尿素包含 i) 每 100 克聚氨酯脲中含有约 2 至 200 毫当量的化学合成阴离子基团，以及 ii) 以聚氨酯脲重量为基准，含有环氧乙烷单元的侧亲水链和/或端亲水链的重量比高达约 15%，其中阴离子基团的反离子是挥发性和非挥发性阳离子的混合物，等效比例约为 1:10 至 10:1。 本发明还涉及用这些分散体制备的涂料和薄膜。
• Verfahren zur Herstellung von wässrigen Polyurethan-Polyharnstoffdispersionen
  申请人：BAYER AG

  公开号：EP0312890A2

  公开（公告）日：1989-04-26

  Wäßrige Polyurethan-Polyharnstoffdispersionen werden hergestellt durch Umsetzung eines Isocyanates mit wenigstens zwei isocyanatreaktiven Verbindungen von denen die eine ionische oder potentiell ionische Gruppen aufweist, wobei das Isocyanat zunächst mit der ionische oder potentiell ionische Gruppen aufweisenden Verbindun­gen umgesetzt wird.

  水性聚氨酯-聚脲分散体的制备方法是将异氰酸酯与至少两种异氰酸酯反应化合物（其中一种具有离子基团或潜在离子基团）反应，异氰酸酯首先与具有离子基团或潜在离子基团的化合物反应。