(3-Methoxymethoxy-5-methyl-2-trimethylstannanyl-phenyl)-carbamic acid tert-butyl ester | 137039-27-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (3-Methoxymethoxy-5-methyl-2-trimethylstannanyl-phenyl)-carbamic acid tert-butyl ester
• 英文别名: tert-butyl N-[3-(methoxymethoxy)-5-methyl-2-trimethylstannylphenyl]carbamate
• CAS: 137039-27-1
• 化学式: C₁₇H₂₉NO₄Sn
• 分子量: 430.132
• InChiKey: NBNRTQZIVLCBBQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.87
• 重原子数：
  23
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.59
• 拓扑面积：
  56.8
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2-bromo-5-hydroxy-[1,4]naphthoquinone 、 (3-Methoxymethoxy-5-methyl-2-trimethylstannanyl-phenyl)-carbamic acid tert-butyl ester 在 四(三苯基膦)钯 、 copper(I) bromide 作用下， 以 1,4-二氧六环 为溶剂， 反应 3.0h， 以100%的产率得到[2-(5-Hydroxy-1,4-dioxo-1,4-dihydro-naphthalen-2-yl)-3-methoxymethoxy-5-methyl-phenyl]-carbamic acid tert-butyl ester
  参考文献：
  名称：

  Palladium-catalyzed coupling of 2-bromonaphthoquinones with stannanes: a concise synthesis of antibiotics WS 5995 A and C and related compounds

  摘要：

  The syntheses of antibiotics WS 5995 A and C and a hypothetical intermediate in the biosynthesis of the kinamycin antibiotics have been completed by using as the key step the palladium-catalyzed coupling of 2-bromo-1,4-naphthoquinones with stannanes.

  DOI：

  10.1021/jo00023a004

文献信息

• Palladium-catalyzed coupling of 2-bromonaphthoquinones with stannanes: a concise synthesis of antibiotics WS 5995 A and C and related compounds
  作者：Nuria Tamayo、Antonio M. Echavarren、M. Carmen Paredes

  DOI：10.1021/jo00023a004

  日期：1991.11

  The syntheses of antibiotics WS 5995 A and C and a hypothetical intermediate in the biosynthesis of the kinamycin antibiotics have been completed by using as the key step the palladium-catalyzed coupling of 2-bromo-1,4-naphthoquinones with stannanes.