Piperazine, 1-ethyl-4-(2-pyridinylmethyl)-

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: Piperazine, 1-ethyl-4-(2-pyridinylmethyl)-
• 英文别名: 1-ethyl-4-(pyridin-2-ylmethyl)piperazine
• 化学式: C₁₂H₁₉N₃
• 分子量: 205.3
• InChiKey: WEHAJFDQSVYMCZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  15
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.58
• 拓扑面积：
  19.4
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• AMIDES OF THIENO[2,3-d]PYRIMIDINE AND THEIR USE AS ADENOSINE A2a RECEPTOR ANTAGONISTS
  申请人：CHAKRAVARTY Devraj

  公开号：US20100093714A1

  公开（公告）日：2010-04-15

  This invention relates to a novel thieno[2,3-d]pyrimidine, A, and its therapeutic and prophylactic uses, wherein R 1 and R 2 are defined in the specification. Disorders treated and/or prevented include Parkinson's Disease.

  本发明涉及一种新型噻吩[2,3-d]嘧啶A及其治疗和预防用途，其中R1和R2在说明书中有定义。所治疗和/或预防的疾病包括帕金森病。
• TRICYCLIC GYRASE INHIBITORS
  申请人：TRIUS THERAPEUTICS INC.

  公开号：US20150246934A1

  公开（公告）日：2015-09-03

  Disclosed herein are compounds having the structure of Formula I and pharmaceutically suitable salts, esters, and prodrugs thereof that are useful as antibacterially effective tricyclic gyrase inhibitors. In addition, species of tricyclic gyrase inhibitors compounds are also disclosed herein. Related pharmaceutical compositions, uses and methods of making the compounds are also contemplated.

  本文揭示了具有I式结构的化合物及其药物适宜的盐、酯和前药，它们可用作具有抗菌作用的三环酶抑制剂。此外，本文还揭示了三环酶抑制剂化合物的种类。还考虑了相关的制药组合物、用途和制备化合物的方法。
• SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS
  申请人：Array BioPharma, Inc.

  公开号：US20210186959A1

  公开（公告）日：2021-06-24

  Provided herein are compounds of the Formula I: and stereoisomers and pharmaceutically acceptable salts or solvates thereof, in which A, B, X 1 , X 2 , X 3 , X 4 , Ring D, and E have the meanings given in the specification, which are inhibitors of RET kinase and are useful in the treatment and prevention of diseases which can be treated with a RET kinase inhibitor, including RET-associated diseases and disorders.
• US7262186B2
  申请人：——

  公开号：US7262186B2

  公开（公告）日：2007-08-28
• US7244723B2
  申请人：——

  公开号：US7244723B2

  公开（公告）日：2007-07-17