1,2-Diamino-4-benzyl-benzol | 33609-49-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1,2-Diamino-4-benzyl-benzol
• 英文别名: 1,2-diamino-4-benzylbenzene；1-benzyl-3,4-diaminobenzene；4-Benzylbenzene-1,2-diamine
• CAS: 33609-49-3
• 化学式: C₁₃H₁₄N₂
• 分子量: 198.268
• InChiKey: SVGBLPSTNYMRBZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  52
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  、 N-苄氧羰基甘氨酸 、 2-氨基苯酚 、 1,2-Diamino-4-benzyl-benzol 、 trans-4-(N-tert-butoxycarbonylglycyl)amino-N-tert-butoxycarbonyl-L-proline 、 trans-1-(tert-butoxycarbonyl)-4-((tert-butoxycarbonyl)amino)methyl-D-proline 生成 (2R,4R)-4-(Aminomethyl)-N-[(5-benzyl-2-benzimidazolyl)methyl]-2-pyrrolidinecarboxamide
  参考文献：
  名称：

  Efflux pump inhibitors

  摘要：

  描述了具有外排泵抑制剂活性的化合物。还描述了使用这种外排泵抑制剂化合物的方法以及包括这种化合物的药物组合物。

  公开号：

  US06399629B1

文献信息

• Olefin block copolymers processes for producing the same and uses thereof
  申请人：——

  公开号：US20030055179A1

  公开（公告）日：2003-03-20

  The present invention provides polymers having any one of properties including affinity for metals or polar resins, impact resistance, mar resistance, heat resistance, rigidity, oil resistance, transparency, anti-fogging properties, electric insulating properties, high breakdown voltage, coating properties, low-temperature flexibility, moldability, environmental degradation, fluidity and dispersibility, and provides a process for preparation thereof. The olefin block copolymers (A-1) of the invention are represented by the formula (I) PO 1 —g 1 —B 1 (I) (wherein PO 1 is a segment composed of repeating units derived from an olefin having 2 to 20 carbon atoms, g 1 is an ester, ether, amide, imide, urethane, urea, silylether or carbonyl linkage, and B 1 is a segment containing an unsaturated hydrocarbon or a hetero atom). The olefin block copolymers are suitable for uses in adhesives; various molded articles such as construction and civil engineering materials, automobile interior and exterior materials, gasoline tanks, electric and electronic parts, medical care and sanitation materials, materials of miscellaneous goods, resin materials having environmental degradation properties, films and sheets; modifiers and dispersions.

  本发明提供了具有以下任一性质的聚合物，包括对金属或极性树脂的亲和性，抗冲击性，抗刮伤性，耐热性，刚度，耐油性，透明性，防雾性能，电绝缘性能，高击穿电压，涂料性能，低温柔性，可塑性，环境降解性，流动性和分散性，并提供其制备方法。本发明的烯烃嵌段共聚物（A-1）由公式（I）表示：PO1-g1-B1（I）（其中PO1是由具有2至20个碳原子的烯烃衍生的重复单元组成的片段，g1是酯，醚，酰胺，亚胺，脲，硅醚或羰基连接，B1是含有不饱和碳氢化合物或杂原子的片段）。烯烃嵌段共聚物适用于粘合剂；各种成型品，如建筑和土木工程材料，汽车内外饰料，汽油箱，电子和电气零件，医疗保健和卫生材料，杂货物料，具有环境降解性能的树脂材料，薄膜和片材；改性剂和分散剂。
• Efflux pump inhibitors
  申请人：Microcide Pharmaceuticals, Inc.

  公开号：US06399629B1

  公开（公告）日：2002-06-04

  Compounds are described which have efflux pump inhibitor activity. Also described are methods of using such efflux pump inhibitor compounds and pharmaceutical compositions which include such compounds.

  描述了具有外排泵抑制剂活性的化合物。还描述了使用这种外排泵抑制剂化合物的方法以及包括这种化合物的药物组合物。
• BENZOIMIDAZOLE COMPOUND CAPABLE OF INHIBITING PROSTAGLANDIN D SYNTHETASE
  申请人：Urade Yoshihiro

  公开号：US20090281098A1

  公开（公告）日：2009-11-12

  The present invention provides a benzimidazole compound represented by Formula (I) wherein X 1 is oxygen or carbonyl, and R 1 is a furan ring having 1 to 3 substituents or a pyrrole ring that may have 1 to 3 substituents; excluding compounds represented by Formula (I) wherein at least one of the substituents is a phosphoric acid group or a phosphoric ester group; or a salt thereof. The benzimidazole compound or salt thereof has excellent prostaglandin synthase inhibitory activity, and is useful as an agent for preventing and/or treating diseases in which prostaglandin D2 or metabolites thereof participates, such as allergic and inflammatory diseases, and as inhibitor for the exacerbation of Alzheimer's disease or cerebral damage.

  本发明提供了一种由式（I）表示的苯并咪唑化合物，其中X1为氧或羰基，R1为具有1至3个取代基的呋喃环或可能具有1至3个取代基的吡咯环；但不包括式（I）中至少一个取代基为磷酸基或磷酸酯基的化合物；或其盐。该苯并咪唑化合物或其盐具有优异的前列腺素合酶抑制活性，可用作预防和/或治疗前列腺素D2或其代谢物参与的疾病，如过敏性和炎症性疾病，并用作防止阿尔茨海默病或脑损伤恶化的抑制剂。
• Glycidyl sulfonamide compound
  申请人：KANEGAFUCHI KAGAKU KOGYO KABUSHIKI KAISHA

  公开号：EP0339137A2

  公开（公告）日：1989-11-02

  A novel glycidyl sulfonamide compound having a (poly)siloxane main chain of its molecule is used alone or in admixture with an epoxy resin to give a cured material being excellent in flexibility, elongation and impact strength without deteriorating thermal resistance, chemical resistance and water absorption thereof. An epoxy resin composition or a resin composition for an epoxy paint containing a glycidyl sulfonamide compound, the epoxy resin and a curing agent for epoxy resin provides a cured material or a coating film having the above-mentioned excellent properties. A process for preparing a glycidyl sulfonamide compound characterized in that subjecting an amine modified silicone having a (poly)siloxane main chain of its molecule to condensation reaction with a sulfonyl chloride to give a sulfonamide compound, which is subjected to an addition reaction with an epihalohydrin to give the glycidyl sulfonamide compound.

  一种新型缩水甘油基磺酰胺化合物的分子主链为（聚）硅氧烷，单独使用或与环氧树脂混合使用，可得到柔韧性、伸长率和冲击强度极佳的固化材料，而不会降低其耐热性、耐化学性和吸水性。含有缩水甘油磺酰胺化合物、环氧树脂和环氧树脂固化剂的环氧树脂组合物或环氧涂料用树脂组合物可提供具有上述优异性能的固化材料或涂膜。一种制备缩水甘油基磺酰胺化合物的工艺，其特征在于将分子主链为(聚)硅氧烷的胺改性有机硅与磺酰氯进行缩合反应，得到磺酰胺化合物，再与表卤代烃进行加成反应，得到缩水甘油基磺酰胺化合物。
• Novel polyamide and process for the production thereof
  申请人：MITSUI PETROCHEMICAL INDUSTRIES, LTD.

  公开号：EP0476583A2

  公开（公告）日：1992-03-25

  A polyamide comprising a recurring unit of the formula (I),    wherein each of R¹, R², R³, R¹, R⁵, R⁶, R⁷ and R⁸ is independently a hydrogen atom, a halogen atom, a hydroxyl group, or a group of a carbon skeleton which may contain a hetero atom or a halogen atom, and A¹ is a divalent hydrocarbon group; and a process for the production of a polyamide comprising the recurring unit of the formula (I), which comprises subjecting to a polycondensation reaction a dicarboxylic acid comprising an alicyclic dicarboxylic acid of the formula (a)-1, wherein R¹, R², R³, R⁴, R⁵, R⁶, R⁷ and R⁸ are as defined in the formula (I), and a diamine of the formula (b)-1,         H₂N-A¹-NH₂ (b)-1    wherein A¹ is as defined in the formula (I).

  一种聚酰胺，包含式 (I) 的递归单元、 其中 R¹、R²、R³、R¹、R⁵、R⁶、R⁷ 和 R⁸ 各自独立地为氢原子、卤素原子、羟基或可包含杂原子或卤素原子的碳骨架基团，且 A¹ 为二价烃基；以及一种生产包含式(I)循环单元的聚酰胺的工艺，该工艺包括将包含式(a)-1脂环族二羧酸的二羧酸进行缩聚反应、 其中 R¹、R²、R³、R⁴、R⁵、R⁶、R⁷ 和 R⁸ 如式 (I) 所定义，以及式 (b)-1 的二胺、 H₂N-A¹-NH₂ (b)-1 其中 A¹ 如式 (I) 所定义。