苯甲酸,2-(3,5-二氯-2,6-二羟基-4-甲基苯甲酰)-5-羟基-3-甲氧基- | 11029-16-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 苯甲酸,2-(3,5-二氯-2,6-二羟基-4-甲基苯甲酰)-5-羟基-3-甲氧基-
• 英文名称: 2-(3,5-dichloro-2,6-dihydroxy-4-methylbenzoyl)-5-hydroxy-3-methoxybenzoic acid
• 英文别名: 2-(3,5-dichloro-2,6-dihydroxy-4-methyl-benzoyl)-5-hydroxy-3-methoxy-benzoic acid；2-(3,5-Dichlor-2,6-dihydroxy-4-methyl-benzoyl)-5-hydroxy-3-methoxy-benzoesaeure；Dihydroerdin
• CAS: 11029-16-6
• 化学式: C₁₆H₁₂Cl₂O₇
• 分子量: 387.173
• InChiKey: YEEFNWGKVFZRKL-UHFFFAOYSA-N

物化性质

• 熔点：
  240 °C
• 沸点：
  674.8±55.0 °C(Predicted)
• 密度：
  1.616±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  25
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  124
• 氢给体数：
  4
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  苯甲酸,2-(3,5-二氯-2,6-二羟基-4-甲基苯甲酰)-5-羟基-3-甲氧基- 在 硫酸 作用下， 生成 3,5-二氯-2,6-二羟基-4-甲基苯甲酸
  参考文献：
  名称：

  Treatment of pulmonary hypertension during surgery with nitric oxide and vasodilators

  摘要：

  Purpose: To describe the effects of the combination of several therapies on the pulmonary circulation and cardiac function in a patient with severe pulmonary hypertension.Clinical features: We report the case of a female patient with chronic secondary pulmonary hypertension and cardiac failure who underwent right hemicolectomy under general anesthesia. Insertion of a pulmonary artery catheter before the operation revealed pulmonary artery pressure (PAP) of 55/24 mmHg which was lowered moderately by 40 parts per million (ppm) inhNO, During surgery, the patient presented an episode of atrial fibrillation with a slow, irregular heart rate of 45-50 min(-1) and variable systemic pressure. A dipyridamole DPD (0.2 mg.kg(-1)) bolus stabilized systemic pressure and increased heart rate and cardiac output. However, PAP did not change. Nitroglycerine infusion was started at 10 mg.hr(-1) shortly after the initiation of DPD, The patient responded favourably to combined inhNO, intravenous DPD and NTG therapy with a marked and sustained reduction of PAP and a systemic hemodynamic stability.Conclusion: We conclude that: 1) in combination with inhNO, DPD does not augment the inhNO-induced decrease in PAP; 2) DPD improves the hemodynamic profile and elevates cardiac output; 3) therapeutic combination (inhaled NO, NTG, DPD) has a potent effect an pulmonary pressure in cardiac failure patients.

  DOI：

  10.1007/bf03018946
• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 palladium on activated charcoal 、 乙醇 作用下， 生成 苯甲酸,2-(3,5-二氯-2,6-二羟基-4-甲基苯甲酰)-5-羟基-3-甲氧基-
  参考文献：
  名称：

  Raistrick; Smith, Biochemical Journal, 1936, vol. 30, p. 1315,1319

  摘要：

  DOI：

文献信息

• 363. The constitutions of geodin and erdin
  作者：D. H. R. Barton、A. I. Scott

  DOI：10.1039/jr9580001767

  日期：——