N,N-diethyl-4-[(methylamino)methyl]aniline

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N,N-diethyl-4-[(methylamino)methyl]aniline
• 英文别名: N,N-diethyl-4-(methylaminomethyl)aniline
• 化学式: C₁₂H₂₀N₂
• mdl: MFCD07348593
• 分子量: 192.3
• InChiKey: YNVPIIUJOMQLPO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  14
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  15.3
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• Purine based compounds as toll-like receptor 9 antagonist
  申请人：COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH

  公开号：US11168084B2

  公开（公告）日：2021-11-09

  The present invention provides novel purine based compounds of formula 1, method of preparation of purine based compounds and its composition useful for inhibiting signalling through Toll-like receptors. These compounds are useful in inhibiting immune stimulation involving toll-like receptor 9 (TLR9). These can be used in treatment of autoimmune disease and inflammation where aberrant activation of TLR9 plays role.

  本发明提供了新颖的式 1 嘌呤基化合物、嘌呤基化合物的制备方法及其组合物，可用于抑制通过 Toll 样受体发出的信号。这些化合物有助于抑制涉及Toll样受体9（TLR9）的免疫刺激。这些化合物可用于治疗 TLR9 异常激活的自身免疫性疾病和炎症。
• PURINE BASED COMPOUNDS AS TOLL-LIKE RECEPTOR 9 ANTAGONISTS
  申请人：Council of Scientific and Industrial Research

  公开号：EP3707140B1

  公开（公告）日：2021-10-13
• PURINE BASED COMPOUNDS AS TOLL-LIKE RECEPTOR 9 ANTAGONIST
  申请人：COUCIL OF SCIENTIFIC & INDUSTRIAL RESESRCH

  公开号：US20200347062A1

  公开（公告）日：2020-11-05

  The present invention provides novel purine based compounds of formula 1, method of preparation of purine based compounds and its composition useful for inhibiting signalling through Toll-like receptors. These compounds are useful in inhibiting immune stimulation involving toll-like receptor 9 (TLR9). These can be used in treatment of autoimmune disease and inflammation where aberrant activation of TLR9
• US4157343A
  申请人：——

  公开号：US4157343A

  公开（公告）日：1979-06-05