N-[(3-bromophenyl)methyl]-N',N'-diethylethane-1,2-diamine

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-[(3-bromophenyl)methyl]-N',N'-diethylethane-1,2-diamine
• 化学式: C₁₃H₂₁BrN₂
• mdl: MFCD07408574
• 分子量: 285.22
• InChiKey: WASQPTRWKKBJIZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  16
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.538
• 拓扑面积：
  15.3
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• 芳香族アミド
  申请人：ワーナー−ランバート・カンパニー

  公开号：JP2002544186A

  公开（公告）日：2002-12-24

  \n (57)【要約】\nＲ1 、Ｒ2 及びＲ3 がアルキルであり得、Ｘがアルキレンであり、及びＲ4 が非置換又は置換芳香族又はヘテロ芳香族基、例えば、ナフチル又はフルオレニルである式Ｉ：\n【化１】\nの芳香族及びヘテロ芳香族アミドは、痛み、抑うつ、不安、発作、及び精神分裂病の治療に有用なＣＮＳ剤である。\n

  \(57) [摘要] ЈnR1、R2 和 R3 可以是烷基，X 是亚烷基，R4 是未取代或取代的芳香族或杂芳香族基团，例如萘基或芴基。治疗精神分裂症的中枢神经系统药物。\n
• AROMATIC AMIDES
  申请人：WARNER-LAMBERT COMPANY

  公开号：EP1178953B1

  公开（公告）日：2003-12-03
• US6846953B1
  申请人：——

  公开号：US6846953B1

  公开（公告）日：2005-01-25
• [EN] AROMATIC AMIDES<br/>[FR] AMIDES AROMATIQUES
  申请人：WARNER LAMBERT CO

  公开号：WO2000068184A1

  公开（公告）日：2000-11-16

  Aromatic and heteroaromatic amides of formula (I) where R?1, R2 and R3¿ can be alkyl, X is alkylene, and R4 is an unsubstituted or substituted aromatic or heteroaromatic group such as naphthyl or fluorenyl, are CNS agents useful for treating pain, depression, anxiety, seizures, and schizophrenia.
• [EN] METHODS FOR PRODUCTION OF MESODERMAL LINEAGE CELLS<br/>[FR] PROCEDES DE PRODUCTION DE CELLULE DE LIGNEE MESODERMIQUE
  申请人：NOVATHERA LTD

  公开号：WO2005121319A1

  公开（公告）日：2005-12-22

  The invention relates to methods of producing mesodermal lineage cells comprising incubating a pluripotent cell in the presence of HepG2-conditioned medium, an extract thereof or a factor or factors obtainable or obtained therefrom, said extract or factor(s) being capable of inducing initial differentiation of the pluripotent cell. The method can further include culture in conditions that permit formation of embryoid bodies and/or in the presence of a stimulus for mesodermal lineage differentiation. The pluripotent cell can be an embryonic stem cell (ES) or an ectoderm-like primitive (EPL) cell. Methods of the invention may be employed in screening methods. The mesodermal lineage cell can be a cardiogenic cell, mature cardiomyocyte, or a skeletal lineage cell such as an osteogenic cell, mature osteoblast, chondrogenic cell, or a mature chondrocyte.