2-[2-[(3-Phenylmethoxyphenyl)methylamino]ethylamino]ethanol

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-[2-[(3-Phenylmethoxyphenyl)methylamino]ethylamino]ethanol
• 化学式: C₁₈H₂₄N₂O₂
• mdl: MFCD07408602
• 分子量: 300.4
• InChiKey: QHGWCWIBVWKTSP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  22
• 可旋转键数：
  10
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.333
• 拓扑面积：
  53.5
• 氢给体数：
  3
• 氢受体数：
  4

文献信息

• NOVEL P62 LIGAND COMPOUND, AND COMPOSITION FOR PREVENTING, ALLEVIATING, OR TREATING PROTEINOPATHIES COMPRISING SAME
  申请人：Protech Co., Ltd.

  公开号：EP3828163A1

  公开（公告）日：2021-06-02

  The present invention relates to a novel p62 ligand compound, a stereoisomer, hydrate, solvate or prodrug thereof, and a pharmaceutical or food composition for preventing or treating misfolded protein diseases comprising the same as an active ingredient. The p62 ligand compound according to the present invention can be usefully used as a pharmaceutical composition for the prevention, amelioration or treatment of various proteinopathies by activating selective autophagy in cells and thus selectively eliminating in vivo proteins, organelles and aggregates.

  本发明涉及一种新型 p62 配体化合物、其立体异构体、水合物、溶质或原药，以及以其为活性成分的用于预防或治疗折叠错误蛋白质疾病的药物或食品组合物。根据本发明的 p62 配体化合物通过激活细胞中的选择性自噬，从而选择性地消除体内蛋白质、细胞器和聚集体，可有效地用作预防、改善或治疗各种蛋白质疾病的药物组合物。
• NOVEL P62 LIGAND COMPOUND, AND COMPOSITION FOR PREVENTING, AMELIORATING OR TREATING PROTEINOPATHIES COMPRING THE SAME
  申请人：PROTECH Co., Ltd.

  公开号：US20210163399A1

  公开（公告）日：2021-06-03

  The present invention relates to a novel p62 ligand compound, a stereoisomer, hydrate, solvate or prodrug thereof, and a pharmaceutical or food composition for preventing or treating misfolded protein diseases comprising the same as an active ingredient. The p62 ligand compound according to the present invention can be usefully used as a pharmaceutical composition for the prevention, amelioration or treatment of various proteinopathies by activating selective autophagy in cells and thus selectively eliminating in vivo proteins, organelles and aggregates.
• [EN] NOVEL P62 LIGAND COMPOUND, AND COMPOSITION FOR PREVENTING, ALLEVIATING, OR TREATING PROTEINOPATHIES COMPRISING SAME<br/>[FR] NOUVEAU COMPOSÉ LIGAND P62, ET COMPOSITION POUR LA PRÉVENTION, LE SOULAGEMENT OU LE TRAITEMENT DE PROTÉINOPATHIES LE COMPRENANT<br/>[KO] 신규한 p62 리간드 화합물, 이를 포함하는 단백질이상질환의 예방, 개선 또는 치료용 조성물
  申请人：PROTECH CO LTD

  公开号：WO2020022784A1

  公开（公告）日：2020-01-30

  본 발명은 신규한 p62 리간드 화합물, 이의 입체 이성질체, 용매화물, 수화물 또는 프로드럭, 이를 유효성분으로 포함하는 변형단백질환의 예방 또는 치료용 약학적 또는 식품 조성물에 관한 것으로, 본 발명에 따른 p62 리간드 화합물은 세포 내 선택적 오토파지를 활성화하여 체내 단백질, 소기관 및 응고체들을 선택적으로 제거함에 따라 다양한 단백질이상질환의 예방, 개선 또는 치료용 약학적 조성물로 유용하게 사용될 수 있다.