(5S)-5-methyl-5-propan-2-yl-1,3-thiazolidine-2,4-dione

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑烷类
• 英文名称: (5S)-5-methyl-5-propan-2-yl-1,3-thiazolidine-2,4-dione
• 化学式: C₇H₁₁NO₂S
• 分子量: 173.24
• InChiKey: TZNBVPKJLQUCDM-ZETCQYMHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  11
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.71
• 拓扑面积：
  71.5
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• DIPEPTIDE ANALOGS AS TGF-BETA INHIBITORS
  申请人：SOUTHERN RESEARCH INSTITUTE

  公开号：US20190127420A1

  公开（公告）日：2019-05-02

  The present disclosure is concerned with dipeptide analogs that are capable of inhibiting TGF-β and methods of treating cancers such as, for example, multiple myeloma and a hematologic malignancy, methods for immunotherapy, and methods of treating fibrotic conditions using these compounds. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

  本公开涉及能够抑制TGF-β的二肽类似物，以及治疗癌症（例如多发性骨髓瘤和血液恶性肿瘤）、免疫疗法和使用这些化合物治疗纤维化病症的方法。本摘要旨在作为在特定领域搜索的扫描工具，并不意味着对本发明的限制。
• Aryl substituted aminomethyl spectinomycin analogs as antibacterial agents
  申请人：ST. JUDE CHILDREN'S RESEARCH HOSPITAL, INC.

  公开号：US10266544B2

  公开（公告）日：2019-04-23

  The invention relates to aryl substituted aminomethyl spectinomycin analogs, derivatives thereof, and related compounds, which are useful as anti-bacterial agents; methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating anti-bacterial infections using the compounds and compositions.

  本发明涉及芳基取代的氨甲基光谱霉素类似物、其衍生物和相关化合物，可用作抗菌剂；制造这些化合物的方法；包含这些化合物的药物组合物；以及使用这些化合物和组合物治疗抗菌感染的方法。
• Oxygen scavengers, compositions comprising the scavengers, and articles made from the compositions
  申请人：Plastipak Packaging, Inc.

  公开号：US10351692B2

  公开（公告）日：2019-07-16

  The disclosure relates to oxygen scavenging molecules, compositions, methods of making the compositions, articles prepared from the compositions, and methods of making the articles. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

  本公开涉及氧清除分子、组合物、制造组合物的方法、由组合物制备的物品以及制造物品的方法。本摘要旨在作为在特定技术领域进行搜索的扫描工具，并非对本发明的限制。
• Dual inhibitory action peptidomimetic inhibitor for IL-33 and IL-1beta
  申请人：GEORGE MASON UNIVERSITY

  公开号：US10927155B2

  公开（公告）日：2021-02-23

  In one aspect, the invention relates to compositions comprising peptides and/or peptidomimetic compounds, methods of making same, pharmaceutical compositions comprising same, and methods of treating various diseases, including, but not limited to, arthritis, obstructive lung disease, psoriasis, asthma, a defect in hematopoiesis, a neoplasia, a fungal infection, a parasitic infection, or an autoimmune disease, such as, but not limited to, rheumatoid arthritis, atopic allergy, anaphylaxis, psoriasis, asthma, lupus erythematosis, a myeloid cell disorder, or a eosinophil cell disorder. In an aspect, the disclosed peptides and/or compounds inhibit the interaction of IL-1RAcP with the ST2 and IL33 receptor/cytokine complexes. In a further aspect, the disclosed peptides and/or compounds inhibit the interaction of IL-1RAcP with the IL-1R1 and IL-1β receptor/cytokine complexes. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

  在一个方面，本发明涉及包含肽和/或仿肽化合物的组合物、其制造方法、包含其的药物组合物以及治疗各种疾病的方法，这些疾病包括但不限于关节炎、阻塞性肺病、银屑病、哮喘、造血缺陷、肿瘤、真菌感染、寄生虫感染或自身免疫性疾病，例如但不限于类风湿性关节炎、哮喘、造血缺陷、肿瘤、真菌感染、寄生虫感染或自身免疫性疾病，例如但不限于类风湿性关节炎、特应性过敏、过敏性休克、银屑病、哮喘、红斑狼疮、髓细胞疾病或嗜酸性粒细胞疾病。在一个方面，所公开的肽和/或化合物可抑制 IL-1RAcP 与 ST2 和 IL33 受体/细胞因子复合物的相互作用。再一方面，所公开的肽和/或化合物抑制 IL-1RAcP 与 IL-1R1 和 IL-1β 受体/细胞因子复合物的相互作用。本摘要旨在作为一种扫描工具，用于特定技术领域的检索，并非对本发明的限制。
• Dipeptide analogs as TGF-beta inhibitors
  申请人：SOUTHERN RESEARCH INSTITUTE

  公开号：US11046729B2

  公开（公告）日：2021-06-29

  The present disclosure is concerned with dipeptide analogs that are capable of inhibiting TGF-β and methods of treating cancers such as, for example, multiple myeloma and a hematologic malignancy, methods for immunotherapy, and methods of treating fibrotic conditions using these compounds. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

  本公开涉及能够抑制 TGF-β 的二肽类似物，以及使用这些化合物治疗诸如多发性骨髓瘤和血液恶性肿瘤等癌症的方法、免疫治疗方法和治疗纤维化病症的方法。本摘要旨在作为在特定技术领域进行搜索的扫描工具，并非对本发明的限制。