N-(2-甲氧基苯基)呋喃-2-甲酰胺 | 58050-50-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: N-(2-甲氧基苯基)呋喃-2-甲酰胺
• 英文名称: N-(2-methoxyphenyl)furan-2-carboxamide
• CAS: 58050-50-3
• 化学式: C₁₂H₁₁NO₃
• mdl: MFCD00159493
• 分子量: 217.224
• InChiKey: YLJBQYLAGGHKAM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  16
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.083
• 拓扑面积：
  51.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  糠酰胺 、 2-氯苯甲醚 在 potassium phosphate 、 2-二叔丁基膦-2′,4′,6′-三异丙基-3,6-二甲氧基-1,1′-联苯 、 水 、 palladium diacetate 作用下， 以 叔丁醇 为溶剂， 反应 2.0h， 以96%的产率得到N-(2-甲氧基苯基)呋喃-2-甲酰胺
  参考文献：
  名称：

  An efficient system for the Pd-catalyzed cross-coupling of amides and aryl chlorides

  摘要：

  A catalyst based on a new biarylphosphine ligand (3) for the Pd-catalyzed cross-coupling reactions of amides and aryl chlorides is described. This system shows the highest turnover frequencies reported to date for these reactions, especially for aryl chloride substrates bearing an ortho substituent. An array of amides and aryl chlorides were successfully reacted in good to excellent yields. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2009.04.096

文献信息

• AZABICYCLIC-SUBSTITUTED-HETEROARYL COMPOUNDS FOR THE TREATMENT OF DISEASE
  申请人：PHARMACIA & UPJOHN COMPANY

  公开号：EP1442041A1

  公开（公告）日：2004-08-04
• AZABICYCLIC COMPOUNDS FOR THE TREATMENT OF FIBROMYALGIA SYNDROME
  申请人：AstraZeneca AB

  公开号：EP1453828A2

  公开（公告）日：2004-09-08
• [EN] AZABICYCLIC COMPOUNDS FOR THE TREATMENT OF FIBROMYALGIA SYNDROME<br/>[FR] TRAITEMENT DU SYNDROME DE LA FIBROMYALGIE
  申请人：ASTRAZENECA AB

  公开号：WO2003032897A2

  公开（公告）日：2003-04-24

  A method for treating fibromyalgia syndrome with an agonist of α7 nicotinic acetylcholine receptors.
• [EN] AZABICYCLIC-SUBSTITUTED-HETEROARYL COMPOUNDS FOR THE TREATMENT OF DISEASE<br/>[FR] COMPOSES HETEROARYLES SUBSTITUES AZABICYCLIQUES POUR LE TRAITEMENT DE MALADIES
  申请人：UPJOHN CO

  公开号：WO2003040147A1

  公开（公告）日：2003-05-15

  The invention provides compounds of Formula (I): Azabicyclo-N(R1)-C(=X)-W These compounds may be in the form of pharmaceutical salts or compositions, racemic mixtures, or pure enantiomers thereof. The compounds of Formula (I) are useful in pharmaceuticals in which α7 is known to be involved.
• An efficient system for the Pd-catalyzed cross-coupling of amides and aryl chlorides
  作者：Brett P. Fors、Karin Dooleweerdt、Qingle Zeng、Stephen L. Buchwald

  DOI：10.1016/j.tet.2009.04.096

  日期：2009.8

  A catalyst based on a new biarylphosphine ligand (3) for the Pd-catalyzed cross-coupling reactions of amides and aryl chlorides is described. This system shows the highest turnover frequencies reported to date for these reactions, especially for aryl chloride substrates bearing an ortho substituent. An array of amides and aryl chlorides were successfully reacted in good to excellent yields. (C) 2009 Elsevier Ltd. All rights reserved.