(1S)-1-(4-tert-butyl-2,6-dimethylphenyl)ethanol

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (1S)-1-(4-tert-butyl-2,6-dimethylphenyl)ethanol
• 化学式: C₁₄H₂₂O
• 分子量: 206.328
• InChiKey: PVMCWDVJAORYKU-NSHDSACASA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  4-叔丁基-2,6-二甲基乙酰苯 在 甲基二乙氧基硅烷 、 C₃₆H₃₁FeN₃O₃ 、 potassium carbonate 作用下， 以 甲苯 、 甲醇 为溶剂， 反应 7.0h， 以95%的产率得到(1S)-1-(4-tert-butyl-2,6-dimethylphenyl)ethanol
  参考文献：
  名称：

  Iron Achieves Noble Metal Reactivity and Selectivity: Highly Reactive and Enantioselective Iron Complexes as Catalysts in the Hydrosilylation of Ketones

  摘要：

  Chiral iron alkyl and iron alkoxide complexes bearing boxmi pincers as stereodirecting ligands have been employed as catalysts for enantioselective hydrosilylation reactions with unprecedented activity and selectivity (TOF = 240 h(-1) at -40 degrees C, ee up to 99% for alkyl aryl ketones), which match the performance of previously established noble-metal-based catalysts. This shows the potential of earth-abundant metals such as iron for replacing platinum-metals without any drawbacks for the reaction design.

  DOI：

  10.1021/ja512986m