1,5-dibenzylimidazolidin-2-one | 1131457-31-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑烷类
• 英文名称: 1,5-dibenzylimidazolidin-2-one
• CAS: 1131457-31-2
• 化学式: C₁₇H₁₈N₂O
• 分子量: 266.343
• InChiKey: NFVAOTPEJQMFBA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  20
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  32.3
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  1-allyl-3-benzylurea 、 苯硼酸 在 SIMes-AuCl 作用下， 以 乙腈 为溶剂， 反应 24.0h， 以88%的产率得到1,5-dibenzylimidazolidin-2-one
  参考文献：
  名称：

  ñ -杂环卡宾-金（I）化合物与芳基硼酸的烯烃的催化的carboheterofunctionalization

  摘要：

  通过一种新方法吡咯烷，四氢呋喃，和咪唑烷-2-酮的合成Ñ -杂环卡宾-金（I）催化的分子内的氨基或oxyarylation从各种各样的烯烃底物如反应的ñ -烯丙基酰胺，醇已经开发出在温和条件下在Selectfluor的存在下制备羧酸，羧酸和脲的方法。

  DOI：

  10.1016/j.tet.2013.09.097

文献信息

• The Direct Synthesis of Unsymmetrical Vicinal Diamines from Terminal Alkynes: A Tandem Sequential Approach for the Synthesis of Imidazolidinones
  作者：Laurel Schafer、Alison Lee、Melanie Sajitz

  DOI：10.1055/s-0028-1083279

  日期：2009.1

  reaction is used in the synthesis of unsymmetrical vicinal diamines via the one-pot synthesis of α-cyanoamines. This methodology is further applied to the efficient synthesis of imidazolidinones. An easy-to-use bis(amidate)titanium precatalyst permits efficient approaches to heterocyclic chemistry from terminal alkynes. hydroamination - titanium - amines - heterocycles - tandem reactions

  钛的末端炔烃抗Markovnikov加氢胺化与Strecker反应的结合用于通过一锅法合成α-氰胺合成不对称的邻二胺。该方法进一步应用于咪唑烷酮的有效合成。易于使用的双（氨基）钛预催化剂可以从末端炔烃中高效地进行杂环化学反应。 加氢胺化-钛-胺-杂环-串联反应
• BENZYLATED PDE4 INHIBITORS
  申请人：Lauener W. Ronald

  公开号：US20070208181A1

  公开（公告）日：2007-09-06

  The present invention is directed to a method for reducing the emetogenic effects of PDE inhibitors, and more particularly is directed to compounds having PDE4 inhibition activity with little or no emetogenic side-effects, and chemical methods including benzylation for preparing such compounds. A benzyl group may be attached to either a carbon or nitrogen atom of a PDE4 inhibitor. Suitable benzylation chemistry is to extract a hydrogen from a PDE4 inhibitor, preferably with a base, and then react the resulting nucleophilic PDE4 inhibitor with a benzylating agent, e.g., benzyl bromide or a derivative thereof.
• US7459479B2
  申请人：——

  公开号：US7459479B2

  公开（公告）日：2008-12-02
• N-Heterocyclic carbene–gold(I)-catalyzed carboheterofunctionalization of alkenes with arylboronic acids
  作者：Shifa Zhu、Lijuan Ye、Wanqing Wu、Huanfeng Jiang

  DOI：10.1016/j.tet.2013.09.097

  日期：2013.12

  A new approach to the synthesis of pyrrolidine, tetrahydrofuran, and imidazolidin-2-one via N-heterocyclic carbene–gold(I)-catalyzed intramolecular amino- or oxyarylation reactions from a wide variety of alkene substrates such as N-allyl amides, alcohols, carboxylic acids, and ureas in the presence of Selectfluor under mild conditions has been developed.

  通过一种新方法吡咯烷，四氢呋喃，和咪唑烷-2-酮的合成Ñ -杂环卡宾-金（I）催化的分子内的氨基或oxyarylation从各种各样的烯烃底物如反应的ñ -烯丙基酰胺，醇已经开发出在温和条件下在Selectfluor的存在下制备羧酸，羧酸和脲的方法。