3-[5-(2-Chlorophenyl)furan-2-yl]prop-2-enal

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3-[5-(2-Chlorophenyl)furan-2-yl]prop-2-enal
• 化学式: C₁₃H₉ClO₂
• 分子量: 232.666
• InChiKey: WIJLDDAOIMZBMA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  16
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  30.2
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  3-[5-(2-Chlorophenyl)furan-2-yl]prop-2-enal 在 sodium tetrahydroborate 、 sodium acetate 作用下， 以 甲醇 、 乙醇 、 苯 为溶剂， 反应 29.0h， 生成 (4RS,4aRS,7aSR)-6-(4-methoxyphenyl)-5-oxo-2-(2-chlorophenyl)-4a,5,6,7,7a,8-hexahydro-4H-furo[2,3-f]isoindole-4-carboxylic acid
  参考文献：
  名称：

  分子内Diels–Alder乙烯基呋喃（IMDAV）反应：品脱癸烷型倍半萜烯氮杂类似物的短途径

  摘要：

  易于获得的（3-呋喃基）烯丙胺与顺丁烯二酸酐的反应，然后是涉及酰化/环加成/质子转移步骤的多米诺序列，导致呋喃[2,3 - f ]异吲哚的形成，即吡gui烷的氮杂类似物型倍半萜。关键的分子内Diels–Alder乙烯基呋喃（IMDAV）反应在温和的条件下进行，具有高水平的非对映选择性和令人满意的收率。

  DOI：

  10.1016/j.tetlet.2015.05.115

文献信息

• Bi-functional complexes and methods for making and using such complexes
  申请人：Gouliaev Alex Haahr

  公开号：US11225655B2

  公开（公告）日：2022-01-18

  The present invention is directed to a method for the synthesis of a bi-functional complex comprising a molecule part and an identifier oligonucleotide part identifying the molecule part. A part of the synthesis method according to the present invention is preferably conducted in one or more organic solvents when a nascent bi-functional complex comprising an optionally protected tag or oligonucleotide identifier is linked to a solid support, and another part of the synthesis method is preferably conducted under conditions suitable for enzymatic addition of an oligonucleotide tag to a nascent bi-functional complex in solution.

  本发明涉及一种合成双功能复合物的方法，该复合物包括分子部分和识别分子部分的识别寡核苷酸部分。根据本发明的合成方法的一部分优选在一种或多种有机溶剂中进行，此时包含可选保护标签或寡核苷酸标识符的新生双功能复合物与固体支持物相连接，合成方法的另一部分优选在适合于将寡核苷酸标签酶加到溶液中的新生双功能复合物的条件下进行。
• BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES
  申请人：Nuevolution A/S

  公开号：EP2558577A1

  公开（公告）日：2013-02-20
• BI-FUNCTINAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES
  申请人：Gouliaev Alex Haahr

  公开号：US20130281324A1

  公开（公告）日：2013-10-24

  The present invention is directed to a method for the synthesis of a bi-functional complex comprising a molecule part and an identifier oligonucleotide part identifying the molecule part. A part of the synthesis method according to the present invention is preferably conducted in one or more organic solvents when a nascent bi-functional complex comprising an optionally protected tag or oligonucleotide identifier is linked to a solid support, and another part of the synthesis method is preferably conducted under conditions suitable for enzymatic addition of an oligonucleotide tag to a nascent bi-functional complex in solution.
• [EN] BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES<br/>[FR] COMPLEXES BIFONCTIONNELS ET PROCÉDÉS DE FABRICATION ET D'UTILISATION DE TELS COMPLEXES
  申请人：NUEVOLUTION AS

  公开号：WO2011127933A1

  公开（公告）日：2011-10-20

  The present invention is directed to a method for the synthesis of a bi-functional complex comprising a molecule part and an identifier oligonucleotide part identifying the molecule part. A part of the synthesis method according to the present invention is preferably conducted in one or more organic solvents when a nascent bi-functional complex comprising an optionally protected tag or oligonucleotide identifier is linked to a solid support, and another part of the synthesis method is preferably conducted under conditions suitable for enzymatic addition of an oligonucleotide tag to a nascent bi-functional complex in solution.
• The intramolecular Diels–Alder vinylfuran (IMDAV) reaction: a short approach to aza-analogues of pinguisane-type sesquiterpenes
  作者：Yuriy I. Horak、Roman Z. Lytvyn、Yuriy V. Homza、Vladimir P. Zaytsev、Dmitriy F. Mertsalov、Maria N. Babkina、Eugenia V. Nikitina、Tadeusz Lis、Vasyl Kinzhybalo、Vasyl S. Matiychuk、Fedor I. Zubkov、Alexey V. Varlamov、Mykola D. Obushak

  DOI：10.1016/j.tetlet.2015.05.115

  日期：2015.7

  The reaction of readily accessible (3-furyl)allylamines with maleic anhydride, followed by a domino sequence involving acylation/cycloaddition/proton shift steps, led to the formation of furo[2,3-f]isoindoles—the aza-analogs of pinguisane-type sesquiterpenes. The key intramolecular Diels–Alder vinylfuran (IMDAV) reaction proceeded under mild conditions, with high levels of diastereoselectivity and

  易于获得的（3-呋喃基）烯丙胺与顺丁烯二酸酐的反应，然后是涉及酰化/环加成/质子转移步骤的多米诺序列，导致呋喃[2,3 - f ]异吲哚的形成，即吡gui烷的氮杂类似物型倍半萜。关键的分子内Diels–Alder乙烯基呋喃（IMDAV）反应在温和的条件下进行，具有高水平的非对映选择性和令人满意的收率。