(3S,4S)-3-hydroxy-4-methoxypyrrolidine hydrochloride | 473298-23-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 英文名称: (3S,4S)-3-hydroxy-4-methoxypyrrolidine hydrochloride
• 英文别名: trans-4-Methoxypyrrolidin-3-ol hydrochloride；(3S,4S)-4-methoxypyrrolidin-3-ol;hydrochloride
• CAS: 473298-23-6
• 化学式: C₅H₁₁NO₂*ClH
• 分子量: 153.609
• InChiKey: AGYFNYDVGSRXSM-FHAQVOQBSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.61
• 重原子数：
  9
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  41.5
• 氢给体数：
  3
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  hydrochloric acid-ethyl acetate 、 palladium hydroxide-carbon 、 (3S,4S)-((1'S)-1-(1'-phenylethyl)-3-hydroxy-4-methoxypyrrolidine 、 异丙醇 生成 (3S,4S)-3-hydroxy-4-methoxypyrrolidine hydrochloride
  参考文献：
  名称：

  摘要：

  DOI：

文献信息

• Process for producing stereoisomer of pyrrolidine derivative
  申请人：——

  公开号：US20030004208A1

  公开（公告）日：2003-01-02

  The present invention provides a process for producing optically active 3-hydroxy-4-methoxypyrrolidine, which is an intermediate for synthesizing a quinuclidine derivative useful as a squalene synthetase inhibitor, a salt thereof, or a hydrate thereof by subjecting a pyrrolidine derivative represented by the following formula (1-4): 1 wherein R 3a and R 3b are different and each of R 3a and R 3b represents a hydrogen atom or a methyl group, to optical division purification by using an optically active dibenzoyltartaric acid derivative or the like.

  本发明提供了一种用于生产光学活性的3-羟基-4-甲氧基吡咯烷的方法，这是一种合成作为角鲨烯合酶抑制剂有用的喹努啉衍生物的中间体，其盐类，或者其水合物，通过使用光学活性的二苯甲酰酒石酸衍生物等，对以下式子(1-4)所表示的吡咯烷衍生物进行光学分离纯化： 1 式中，R 3a 和R 3b 不同，R 3a 和R 3b 各自代表一个氢原子或甲基基团。
• [EN] BENZAMIDE DERIVATIVES FOR INHIBITING THE ACTIVITY OF ABL1, ABL2 AND BCR-ABL1<br/>[FR] DÉRIVÉS DE BENZAMIDE POUR INHIBER L'ACTIVITÉ D'ABL1, D'ABL2 ET DE BCR-ABL2
  申请人：NOVARTIS AG

  公开号：WO2013171640A1

  公开（公告）日：2013-11-21

  The present invention relates to compounds of formula (I): in which Y, Y, R, R 2, R 3 and R 4 are defined in the Summary of the Invention; capable of inhibiting the activity of BCR-ABL1 and mutants thereof. The invention further provides a process for the preparation of compounds of the invention, pharmaceutical preparations comprising such compounds and methods of using such compounds in the treatment of cancers.

  本发明涉及式(I)的化合物：其中Y、Y、R、R 2、R 3和R 4在发明摘要中有定义；能够抑制BCR-ABL1及其突变体的活性。本发明还提供了一种制备本发明化合物的方法，包括含有这种化合物的药物制剂以及使用这种化合物治疗癌症的方法。
• COMPOUNDS AND COMPOSITIONS FOR INHIBITING THE ACTIVITY OF ABL1, ABL2 AND BCR-ABL1
  申请人：Furet Pascal

  公开号：US20150183801A1

  公开（公告）日：2015-07-02

  The present invention relates to compounds of formula (I): in which Y, Y, R, R 2, R 3 and R 4 are defined in the Summary of the Invention; capable of inhibiting the activity of BCR-ABL1 and mutants thereof. The invention further provides a process for the preparation of compounds of the invention, pharmaceutical preparations comprising such compounds and methods of using such compounds in the treatment of cancers.

  本发明涉及式(I)的化合物：其中Y，Y，R，R2，R3和R4在发明摘要中定义; 能够抑制BCR-ABL1及其突变体的活性。本发明还提供了一种制备本发明化合物的方法，包括这些化合物的制药制剂以及使用这些化合物治疗癌症的方法。
• Pyrazolopyrimidines having activity against the respiratory syncytial virus (RSV)
  申请人：Janssen Sciences Ireland Unlimited Company

  公开号：US11339165B2

  公开（公告）日：2022-05-24

  The invention concerns compounds having antiviral activity, in particular, having an inhibitory activity on the replication of the respiratory syncytial virus (RSV). The invention further concerns pharmaceutical compositions comprising these compounds and the compounds for use in the treatment of respiratory syncytial virus infection. Formula (Ia).

  本发明涉及具有抗病毒活性的化合物，尤其是对呼吸道合胞病毒（RSV）的复制具有抑制活性的化合物。本发明还涉及包含这些化合物的药物组合物以及用于治疗呼吸道合胞病毒感染的化合物。式 (Ia).
• BENZAMIDE DERIVATIVES FOR INHIBITING THE ACTIVITY OF ABL1, ABL2 AND BCR-ABL1
  申请人：Novartis AG

  公开号：EP2858988A1

  公开（公告）日：2015-04-15