Tridecanoic acid 4-nitro-phenyl ester | 79644-27-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚酯
• 英文名称: Tridecanoic acid 4-nitro-phenyl ester
• 英文别名: 4-Nitrophenyl tridecanoate；(4-nitrophenyl) tridecanoate
• CAS: 79644-27-2
• 化学式: C₁₉H₂₉NO₄
• 分子量: 335.444
• InChiKey: MLCRTZQIDARSHX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.2
• 重原子数：
  24
• 可旋转键数：
  13
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.63
• 拓扑面积：
  72.1
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  Tridecanoic acid 4-nitro-phenyl ester 在 水 作用下， 生成 对硝基苯酚 、 十三酸
  参考文献：
  名称：

  Oxidation reactions using air as oxidant thanks to silica nanoreactors containing GOx/peroxidases bienzymatic systems

  摘要：

  Anew kind of enzymes encapsulation method is presented It combines the sol-gel method with a templating process using Mayers of phospholipids to provide an organized network of phospholipids inside the silica and in the same time protect the embedded enzymes as if they were entrapped in a biological membrane supported on silica This brings a porosity control to the classical sol-gel encapsulation and therefore increases the accessibility of the substrates to a maximum of enzymes A first family of hybrid phospholipids-silica materials named Sponge mesoporous silica (SMS) has been synthesized which features a sponge-like structure The formation of a negative curvature in the rigid phospholipid Mayers was induced by adding ethanol (>50%) to the aqueous medium which provokes the separation of the head groups and the undulations of the lipid Mayers Dodecylamine added to stabilize this structure acts as a catalyst for silica condensation Lactose was added to avoid direct interaction of the enzymes with the silica at the interface with the lipids bilayer Lipase was encapsulated in SMS and shows higher activity for ester hydrolysis compared to commercial immobilized-lipase An experiment design plan was carried out to optimize SMS synthesis using hemoglobin (Hb) as biocatalyst for oxidation reactions using H2O2 As a result a new structure was identified formed by the aggregation of nanoporous silica capsules named NPS with a higher activity compared to SMS biocatalysts These new biological nanoreactors were used to encapsulate simulteanously Hb and glucose oxidase to produce in situ H2O2 from air and perform oxidation reactions This system was used for the elimination of the carcinogenic polycyclic aromatic hydrocarbon pollutants from water (C) 2010 Elsevier B V All rights reserved

  DOI：

  10.1016/j.cattod.2010.02.065
• 作为产物：
  描述：

  十三酸 、 对硝基苯酚 生成 Tridecanoic acid 4-nitro-phenyl ester
  参考文献：
  名称：

  JIANG, XI-KUI;HUI, YONG-ZHENG;FAN, WEI-QIANG;WANG, SHU-JING, ACTA CHIM. SIN., 1985, 43, N 10, 983-987

  摘要：

  DOI：

文献信息

• POLYMER ENHANCEMENT OF ENZYMATIC ACTIVITY
  申请人：The Regents of the University of California

  公开号：US20150344924A1

  公开（公告）日：2015-12-03

  Provided herein are methods for enhancing enzymatic activity using certain polymers that may be optionally attached to an enzyme. The polymers may be thermally-responsive polymers, including poly N-isopropylacrylamide or poly N-isopropylmethacrylamide. The polymer may also be a copolymer with at least two different monomer residues. The monomer residues may have a structure of formula (I): wherein R 1 , R A and R B are as described herein. Examples of such monomer residues may include N-isopropylacrylamide (NIPAm) or N-isopropylmethacrylamide (NIPMa). The polymer may include additional monomer residues, such as aminooxy-bearing methacrylamide monomer residues that can be modified to vary the lower critical solution temperature (LCST) of the polymer.

  本文提供了一种利用某些聚合物增强酶活性的方法，这些聚合物可以选择性地附着在酶上。这些聚合物可以是热响应性聚合物，包括聚N-异丙基丙烯酰胺或聚N-异丙基甲基丙烯酰胺。该聚合物也可以是至少含有两种不同单体残基的共聚物。这些单体残基可能具有以下结构（I）的结构：其中R1，RA和RB如本文所述。此类单体残基的示例可能包括N-异丙基丙烯酰胺（NIPAm）或N-异丙基甲基丙烯酰胺（NIPMa）。该聚合物可能包括额外的单体残基，例如氨氧基甲基丙烯酰胺单体残基，可以被修改以改变聚合物的临界溶解温度（LCST）。
• Ion-Induced Specificity Change in Polymer-Catalyzed Solvolyses ofp-Nitrophenyl Alkanoates
  作者：Guang-Jia Wang、Wilmer K. Fife

  DOI：10.1002/anie.199715431

  日期：1997.8.4
• Stereoselective Synthesis and Structure−Activity Relationship of Novel Ceramide Trafficking Inhibitors. (1<i>R</i>,3<i>R</i>)-<i>N</i>-(3-Hydroxy-1-hydroxymethyl-3-phenylpropyl)dodecanamide and Its Analogues
  作者：Yoshitaka Nakamura、Ryosuke Matsubara、Hidetoshi Kitagawa、Shū Kobayashi、Keigo Kumagai、Satoshi Yasuda、Kentaro Hanada

  DOI：10.1021/jm0300779

  日期：2003.8.1

  New ceramide trafficking inhibitors, (1R,3R)-N-(3-hydroxy-1-hydroxymethyl-3-phenylpropyl)dodecanamide (HPA-12) and a series of its analogues, were synthesized in diastereomerically and enantiomerically pure forms, and the structure-activity relationship was investigated. These analogues were stereoselectively synthesized via catalytic enantioselective Mannich-type reactions using a Cu(II)-chiral diamine 4 complex. Analysis of HPA-12 analogues having various lengths of the amide side chain showed that the optimal chain length for the inhibition of sphingomyelin biosynthesis is 13 with an IC50 of similar to50 nM. Masking of the hydroxy group at the 2'- or 3-position of HPA-12 was carried out by methylation, and it was revealed that these hydroxy groups were essential for the activity. Installation of another hydroxy group onto HPA-12 at the same position as that in the natural ceramide was also conducted, but no enhancement of the activity was observed.
• C-GLYCOLIPIDS WITH ENHANCED TH-1 PROFILE
  申请人：Tsuji Moriya

  公开号：US20100233207A1

  公开（公告）日：2010-09-16

  The invention is directed to novel synthetic C-glycolipids that selectively induce a ThI-type immune response characterized by enhanced IL-12 secretion and increased activation of dendritic cells. The compounds of the invention are thereby useful in treating infections, cancers, cell proliferative disorders, and autoimmune diseases, both directly and as adjuvants.
• US9885071B2
  申请人：——

  公开号：US9885071B2

  公开（公告）日：2018-02-06