2-Mercapto-4-(trifluoromethyl)nicotinonitrile

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 2-Mercapto-4-(trifluoromethyl)nicotinonitrile
• 英文别名: 2-sulfanylidene-4-(trifluoromethyl)-1H-pyridine-3-carbonitrile
• 化学式: C₇H₃F₃N₂S
• 分子量: 204.17
• InChiKey: NZEHGJYDGVZZIX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  13
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  67.9
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• Small Molecules for Inhibition of Protein Kinases
  申请人：Desai Renee

  公开号：US20110275645A1

  公开（公告）日：2011-11-10

  The invention provides compounds that inhibit protein kinases, prodrugs of the compounds, intermediates and methods of synthesizing the compounds and/or prodrugs, pharmaceutical compositions including the compounds and/or prodrugs and methods of using the compounds and/or prodrugs in a variety of contexts, including, for example, in the treatment and/or prevention of various diseases that are responsive to protein kinase inhibition and/or that are mediated, at least in part, by inappropriate kinase activity.
• SMALL MOLECULE INHIBITORS OF PROTEIN KINASES
  申请人：Desai Ketan

  公开号：US20130058980A1

  公开（公告）日：2013-03-07

  Compounds that modulate, for example, that inhibit, syk kinase, and, optionally other kinases. The compounds can be used to treat a variety of disorders, including inflammatory disorders and autoimmune disorders.
• US8389525B2
  申请人：——

  公开号：US8389525B2

  公开（公告）日：2013-03-05
• US9212143B2
  申请人：——

  公开号：US9212143B2

  公开（公告）日：2015-12-15
• [EN] SMALL MOLECULE INHIBITORS OF PROTEIN KINASES<br/>[FR] INHIBITEURS À PETITE MOLÉCULE DE PROTÉINE KINASES
  申请人：IMC BIOTECHNOLOGY INC

  公开号：WO2011139295A1

  公开（公告）日：2011-11-10

  Compounds that modulate, for example, that inhibit, syk kinase, and, optionally other kinases. The compounds can be used to treat a variety of disorders, including inflammatory disorders and autoimmune disorders.