N-(3-三乙基铵丙基)-4-(4-(二丁基氨基)苯乙烯基)吡啶二溴盐 | 149838-22-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: N-(3-三乙基铵丙基)-4-(4-(二丁基氨基)苯乙烯基)吡啶二溴盐
• 英文名称: N-(3-(triethylammonium)propyl)-4-(4-(dibutylamino)styryl)pyridinium
• 英文别名: 3-[4-[(E)-2-[4-(dibutylamino)phenyl]ethenyl]pyridin-1-ium-1-yl]propyl-triethylazanium;dibromide
• CAS: 149838-22-2
• 化学式: C30H49Br2N3
• 分子量: 611.5
• InChiKey: VZUVCAGXYLMFEC-UHFFFAOYSA-L

物化性质

• 溶解度：
  可溶于DMSO

计算性质

• 辛醇/水分配系数(LogP)：
  0.83
• 重原子数：
  35
• 可旋转键数：
  16
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  7.1
• 氢给体数：
  0
• 氢受体数：
  3

安全信息

• 安全说明：
  S22,S24/25
• WGK Germany：
  3

SDS

Name:	Neurodye FM1-43 Material Safety Data Sheet
Synonym:
CAS:	149838-22-2

Section 1 - Chemical Product MSDS Name:Neurodye FM1-43 Material Safety Data Sheet
Synonym:

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Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS

CAS#	Chemical Name	content	EINECS#
149838-22-2	Neurodye FM1-43		unlisted

Hazard Symbols: None Listed.
Risk Phrases: None Listed.

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Section 3 - HAZARDS IDENTIFICATION
EMERGENCY OVERVIEW
Light sensitive.
Potential Health Effects
Eye:
May cause eye irritation.
Skin:
May cause skin irritation.
Ingestion:
May cause irritation of the digestive tract. The toxicological properties of this substance have not been fully investigated.
Inhalation:
May cause respiratory tract irritation. The toxicological properties of this substance have not been fully investigated.
Chronic:
Not available.

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Section 4 - FIRST AID MEASURES
Eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.
Skin:
Get medical aid. Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes.
Ingestion:
Get medical aid. Wash mouth out with water.
Inhalation:
Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
Notes to Physician:

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Section 5 - FIRE FIGHTING MEASURES
General Information:
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear.
Extinguishing Media:
Use water spray, dry chemical, carbon dioxide, or chemical foam.

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Section 6 - ACCIDENTAL RELEASE MEASURES
General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Vacuum or sweep up material and place into a suitable disposal container.

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Section 7 - HANDLING and STORAGE
Handling:
Avoid breathing dust, vapor, mist, or gas. Avoid contact with skin and eyes.
Storage:
Store in a cool, dry place. Store in a tightly closed container.

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Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION
Engineering Controls:
Use adequate ventilation to keep airborne concentrations low.
Exposure Limits CAS# 149838-22-2: Personal Protective Equipment Eyes: Not available.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin exposure.
Respirators:
Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced.

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Section 9 - PHYSICAL AND CHEMICAL PROPERTIES

Physical State: Solid
Color: red - orange
Odor: Not available.
pH: Not available.
Vapor Pressure: Not available.
Viscosity: Not available.
Boiling Point: Not available.
Freezing/Melting Point: Not available.
Autoignition Temperature: Not available.
Flash Point: Not available.
Explosion Limits, lower: Not available.
Explosion Limits, upper: Not available.
Decomposition Temperature:
Solubility in water: moderately soluble in water
Specific Gravity/Density:
Molecular Formula:
Molecular Weight: 639.60

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Section 10 - STABILITY AND REACTIVITY
Chemical Stability:
Stable.
Conditions to Avoid:
Light.
Incompatibilities with Other Materials:
Not available.
Hazardous Decomposition Products:
Carbon monoxide, carbon dioxide.
Hazardous Polymerization: Has not been reported

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Section 11 - TOXICOLOGICAL INFORMATION
RTECS#:
CAS# 149838-22-2 unlisted.
LD50/LC50:
Not available.
Carcinogenicity:
Neurodye FM1-43 - Not listed by ACGIH, IARC, or NTP.

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Section 12 - ECOLOGICAL INFORMATION

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Section 13 - DISPOSAL CONSIDERATIONS
Dispose of in a manner consistent with federal, state, and local regulations.

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Section 14 - TRANSPORT INFORMATION

IATA
No information available.
IMO
No information available.
RID/ADR
No information available.

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Section 15 - REGULATORY INFORMATION

European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: Not available.
Risk Phrases:
Safety Phrases:
S 24/25 Avoid contact with skin and eyes.
WGK (Water Danger/Protection)
CAS# 149838-22-2: No information available.
Canada
None of the chemicals in this product are listed on the DSL/NDSL list.
CAS# 149838-22-2 is not listed on Canada's Ingredient Disclosure List.
US FEDERAL
TSCA
CAS# 149838-22-2 is not listed on the TSCA inventory.
It is for research and development use only.

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SECTION 16 - ADDITIONAL INFORMATION
N/A

文献信息

• Lipophilic dye-based FRET assays for clostridial toxin activity
  申请人：ALLERGAN, INC.

  公开号：EP2293064A1

  公开（公告）日：2011-03-09

  Compositions useful for detecting Clostridial toxin activity comprising a cell that comprises a membrane-associated Clostridial toxin substrate comprising a first member of a fluorescence resonance energy transfer pair; and a Clostridial toxin recognition sequence including a cleavage site; and a membrane-associated second member of the FRET pair and methods useful for determining Clostridial toxin activity using such Clostridial toxin substrates.

  用于检测梭状芽孢杆菌毒素活性的组合物，该组合物包含一个细胞，该细胞包含与膜结合的梭状芽孢杆菌毒素底物，该底物包含荧光共振能量转移对的第一位成员；和包括裂解位点的梭状芽孢杆菌毒素识别序列；以及与膜结合的荧光共振能量转移对的第二位成员，以及使用这种梭状芽孢杆菌毒素底物确定梭状芽孢杆菌毒素活性的方法。
• Characterization of subvisible particles using a particle analyzer
  申请人：Baxalta Incorporated

  公开号：US10274500B2

  公开（公告）日：2019-04-30

  The present specification discloses methods of characterizing a population of particles using a particle analyzer. Particles may be characterized by size, absolute number, whether the particle is non-proteinaceous or proteinaceous, whether a proteinaceous particle has or lacks a certain physical property, or any combination thereof.

  本说明书公开了使用颗粒分析仪表征颗粒群的方法。颗粒可以通过大小、绝对数量、颗粒是非蛋白质还是蛋白质、蛋白质颗粒是否具有或缺乏某种物理特性或它们的任意组合来表征。
• High-throughput single molecule protein identification
  申请人：The Trustees of Columbia University in the City of New York

  公开号：US10466248B2

  公开（公告）日：2019-11-05

  The present invention is methods and assays for identifying single proteins from a sample, without the use of affinity reagents. The methods and assays combine endopeptidase-based component of conventional peptide mapping with single molecule labeling and a microreactor array platform. The invention also includes kits for performing the methods and assays.

  本发明是在不使用亲和试剂的情况下从样品中鉴定单个蛋白质的方法和检测方法。这些方法和检测方法将传统肽图谱中基于内肽酶的部分与单分子标记和微反应器阵列平台相结合。本发明还包括用于执行这些方法和检测的试剂盒。
• Method and process for quantitative evaluation of pharmacokinetics, therapeutic effects and safety of delivery of drug compounds to the inner ear for treatment of auditory disease
  申请人：The Charles Stark Draper Laboratory, Inc.

  公开号：US10596267B2

  公开（公告）日：2020-03-24

  The present disclosure provides compositions and methods for treating an auditory disease in a subject in need thereof comprising administering an effective amount of a gel-based precursor that includes an inner ear-specific therapeutic compound directly into the cochlea of the subject.

  本公开提供了用于治疗有需要的受试者听觉疾病的组合物和方法，包括将有效量的凝胶前体直接注入受试者的耳蜗，该凝胶前体包括内耳特异性治疗化合物。
• Rapid antibiotic susceptibility test using membrane fluorescence staining and spectral intensity ratio improved by flow cytometry dead to live population ratio
  申请人：POCARED Diagnostics LTD.

  公开号：US10995358B2

  公开（公告）日：2021-05-04

  Single dye fluorescent staining and the combination of differences in both intensity and spectral emission permit determination of the minimum concentration of an antibiotic needed to inactivate bacteria (Minimum Inhibitory Concentration (MIC)), thereby providing a means for rapid Antibiotic Susceptibility Testing (AST). This allows for a quick and easy means for clinicians to determine a suitable treatment regimen for patients suffering from bacterial infections and those that eventually lead to sepsis.

  通过单染料荧光染色以及结合强度和光谱发射的差异，可以确定灭活细菌所需的最低抗生素浓度（最低抑菌浓度 (MIC)），从而提供快速抗生素敏感性测试 (AST) 的方法。这样，临床医生就可以方便快捷地为细菌感染和最终导致败血症的患者确定合适的治疗方案。