2-hydroxy-N-(2-hydroxy-1-naphthyl)naphthalen-1-amine | 143329-07-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 2-hydroxy-N-(2-hydroxy-1-naphthyl)naphthalen-1-amine
• 英文别名: 1-[(2-Hydroxynaphthalen-1-yl)amino]naphthalen-2-ol；1-[(2-hydroxynaphthalen-1-yl)amino]naphthalen-2-ol
• CAS: 143329-07-1
• 化学式: C₂₀H₁₅NO₂
• 分子量: 301.345
• InChiKey: HRZCZDIEEXIEQV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.3
• 重原子数：
  23
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  52.5
• 氢给体数：
  3
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  2-methoxy-N-(2-methoxy-1-naphthyl)naphthalen-1-amine 在 三溴化硼 、 水 作用下， 以 二氯甲烷 为溶剂， 反应 15.0h， 生成 2-hydroxy-N-(2-hydroxy-1-naphthyl)naphthalen-1-amine
  参考文献：
  名称：

  Design, Synthesis, and Structure–Activity Relationship of N-Arylnaphthylamine Derivatives as Amyloid Aggregation Inhibitors

  摘要：

  Dyes like CR are able to inhibit the aggregation of A beta fibrils. Thus, a screening of a series of dyes including ABBB (1) was performed. Its main component 2 tested in an in vitro assay (i.e., ThT assay) showed good potency at inhibiting fibrils association. Congeners 4-9 have been designed and synthesized as inhibitors of A beta aggregation. A nurnber of these newly synthesized compounds have been found to be active in the ThT assay with IC50 of 1-57.4 mu M. The most potent compound of this series, 4k, showed micromolar activity in this test. Another potent derivative 4q (IC50 = 5.6 mu M) rapidly crossed the blood-brain barrier, achieving whole brain concentrations higher than in plasma. So 4q could be developed to find novel potent antiaggregating beta A agents useful in Alzheimer disease as well as other neurological diseases characterized by deposits of amyloid aggregates.

  DOI：

  10.1021/jm301105m

文献信息

• Design, Synthesis, and Structure–Activity Relationship of <i>N</i>-Arylnaphthylamine Derivatives as Amyloid Aggregation Inhibitors
  作者：Roberto Di Santo、Roberta Costi、Giuliana Cuzzucoli Crucitti、Luca Pescatori、Federica Rosi、Luigi Scipione、Diana Celona、Mario Vertechy、Orlando Ghirardi、Paola Piovesan、Mauro Marzi、Silvio Caccia、Giovanna Guiso、Fabrizio Giorgi、Patrizia Minetti

  DOI：10.1021/jm301105m

  日期：2012.10.11

  Dyes like CR are able to inhibit the aggregation of A beta fibrils. Thus, a screening of a series of dyes including ABBB (1) was performed. Its main component 2 tested in an in vitro assay (i.e., ThT assay) showed good potency at inhibiting fibrils association. Congeners 4-9 have been designed and synthesized as inhibitors of A beta aggregation. A nurnber of these newly synthesized compounds have been found to be active in the ThT assay with IC50 of 1-57.4 mu M. The most potent compound of this series, 4k, showed micromolar activity in this test. Another potent derivative 4q (IC50 = 5.6 mu M) rapidly crossed the blood-brain barrier, achieving whole brain concentrations higher than in plasma. So 4q could be developed to find novel potent antiaggregating beta A agents useful in Alzheimer disease as well as other neurological diseases characterized by deposits of amyloid aggregates.