N-(3-iodophenyl)benzamide | 52807-28-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-(3-iodophenyl)benzamide
• CAS: 52807-28-0
• 化学式: C₁₃H₁₀INO
• mdl: MFCD04681254
• 分子量: 323.13
• InChiKey: YDSSNARSCZZMIP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  29.1
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  (4-(3-ethynylimidazo[1,2-b]pyridazin-6 yl)phenyl)(morpholino)methanone 、 N-(3-iodophenyl)benzamide 在 N-(3-((6-(4-(morpholine-4-carbonyl)phenyl)imidazo[1,2-b]pyridazin-3-yl)ethynyl)phenyl)benzamide 、 crude product 、 silica gel 、 methanol-dichloromethane 作用下， 以to afford N-(3-((6-(4-(morpholine-4-carbonyl)phenyl)imidazo[1,2-b]pyridazin-3-yl)ethynyl)phenyl)benzamide (20.0 mg, 25%, AUC HPLC 97%) as a yellow solid的产率得到N-(3-((6-(4-(morpholine-4-carbonyl)phenyl)imidazo[1,2-b]pyridazin-3-yl)ethynyl)phenyl)benzamide
  参考文献：
  名称：

  BICYCLIC ALKYNE DERIVATIVES AND USES THEREOF

  摘要：

  本发明涉及某些化合物（例如咪唑吡嗪、咪唑吡啶、咪唑吡嗪和咪唑嘧啶化合物），它们作为MAP激酶相互作用激酶MNK2a、MNK2b、MNK1a和MNK1b的抑制剂。本发明还涉及包含这些化合物的制药组合物，并用于预防和治疗疾病（例如增生性疾病（例如癌症）、炎症性疾病、自身免疫性疾病、代谢性疾病和神经退行性疾病（例如自闭症、自闭症谱系障碍、阿尔茨海默病）），以及治疗这些疾病的方法。

  公开号：

  US20160229860A1

文献信息

• Monomer containing electron-withdrawing group and electron-donative group, and copolymer and proton-conductive membrane comprising same
  申请人：JSR Corporation

  公开号：EP1245554A1

  公开（公告）日：2002-10-02

  A monomer containing an electron-withdrawing group and an electron-donative group which can be easily controlled in the upper limit of the amount of a sulfonic acid , which impairs the mechanical properties of a copolymer, and can provide a sulfonated polymer that forms a proton-conductive membrane having a high proton conductivity over a wide temperature range, an excellent mechanical strength and an excellent proton conductivity and showing inhibited swelling in hot water and an aqueous solution of methanol, and a copolymer obtained from the monomer. A monomer containing an electron-withdrawing group and an electron-donative group represented by the following general formula (1) : wherein Y represents a iodine atom, chlorine atom or bromine atom; X represents an electron-withdrawing group; B represents an electron-donative group; and Z represents an aryl group having a specific structure or a monovalent condensed ring hydrocarbon group such as naphthyl group.

  一种含有一个抽电子基团和一个负电子基团的单体，该单体可以很容易地控制磺酸的用量上限，而磺酸会损害共聚物的机械性能，并可以提供一种磺化聚合物，该聚合物可以在很宽的温度范围内形成具有高质子传导性、优异的机械强度和优异的质子传导性的质子传导膜，并在热水和甲醇水溶液中表现出抑制溶胀的特性，以及由该单体得到的共聚物。一种单体，含有由下式通式（1）代表的一个电子吸收基团和一个电子疏导基团： 其中 Y 代表碘原子、氯原子或溴原子；X 代表抽电子基团；B 代表弃电子基团；Z 代表具有特定结构的芳基或一价缩合环烃基团，如萘基。
• Bicyclic alkyne derivatives and uses thereof
  申请人：Agency for Science, Technology and Research

  公开号：US10544149B2

  公开（公告）日：2020-01-28

  The present invention relates to certain compounds (e.g., imidazopyrazine, imidazopyridine, imidazopyridazine and imidazpyrimidine compounds) that act as inhibitors of the MAP kinase interacting kinases MNK2a, MNK2b, MNK1a, and MNK1b. The present invention further relates to pharmaceutical compositions comprising these compounds, and to the use of the compounds for the prevention and treatment of diseases (e.g., proliferative diseases (e.g., cancer), inflammatory diseases, autoimmune diseases, metabolic diseases, and neurodegenerative diseases (e.g. autism, autism spectrum disorders, Alzheimer's disease)), as well as methods of treating these diseases.

  本发明涉及作为MAP激酶相互作用激酶MNK2a、MNK2b、MNK1a和MNK1b的抑制剂的某些化合物（例如咪唑吡嗪、咪唑吡啶、咪唑哒嗪和咪唑嘧啶化合物）。本发明进一步涉及包含这些化合物的药物组合物，以及这些化合物用于预防和治疗疾病（如增殖性疾病（如癌症）、炎症性疾病、自身免疫性疾病、代谢性疾病和神经退行性疾病（如自闭症、自闭症谱系障碍、阿尔茨海默病））以及治疗这些疾病的方法。
• Monomer containing electron-withdrawing group and electron-donative group, and copolymer and proton-conductive membrane comprising same
  申请人：JSR CORPORATION

  公开号：US20020177656A1

  公开（公告）日：2002-11-28

  A monomer containing an electron-withdrawing group and an electron-donative group which can be easily controlled in the upper limit of the amount of a sulfonic acid, which impairs the mechanical properties of a copolymer, and can provide a sulfonated polymer that forms a proton-conductive membrane having a high proton conductivity over a wide temperature range, an excellent mechanical strength and an excellent proton conductivity and showing inhibited swelling in hot water and an aqueous solution of methanol, and a copolymer obtained from the monomer. A monomer containing an electron-withdrawing group and an electron-donative group represented by the following general formula (1): 1 wherein Y represents a iodine atom, chlorine atom or bromine atom; X represents an electron-withdrawing group; B represents an electron-donative group; and Z represents an aryl group having a specific structure or a monovalent condensed ring hydrocarbon group such as naphthyl group.

  一种含有一个抽电子基团和一个供电子基团的单体，该单体可以很容易地控制磺酸的用量上限，该磺酸会损害共聚物的机械性能，可以提供一种磺化聚合物，该聚合物可以在很宽的温度范围内形成具有高质子传导性、优异的机械强度和优异的质子传导性的质子传导膜，并在热水和甲醇水溶液中表现出抑制溶胀的特性，以及由该单体得到的共聚物。一种单体，含有由以下通式（1）表示的一个抽电子基团和一个负电 子基团： 1 其中 Y 代表碘原子、氯原子或溴原子；X 代表抽电子基团；B 代表弃电子基团；Z 代表具有特定结构的芳基或一价缩合环烃基团，如萘基。
• Bicyclic Heteroaryl Compounds
  申请人：ARIAD Pharmaceuticals, Inc.

  公开号：US20200231588A1

  公开（公告）日：2020-07-23

  This invention relates to compounds of the general formula: in which the variable groups are as defined herein, and to their preparation and use.
• US6794480B2
  申请人：——

  公开号：US6794480B2

  公开（公告）日：2004-09-21