17β-methyl-5α-androstan-3-one | 94901-77-6

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: 17β-methyl-5α-androstan-3-one
• 英文别名: 17β-methyl-5α-androstanone-(3)；17β-Methyl-5α-androstanon-(3)；(5S,8S,9S,10S,13R,14S,17S)-10,13,17-trimethyl-1,2,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydrocyclopenta[a]phenanthren-3-one
• CAS: 94901-77-6
• 化学式: C₂₀H₃₂O
• 分子量: 288.473
• InChiKey: YWNZWROMZFKWGD-SAURGQTRSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.7
• 重原子数：
  21
• 可旋转键数：
  0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.95
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  17β-methyl-5α-androstan-3-one 在 一水合肼 、 potassium hydroxide 作用下， 以 二乙二醇 为溶剂， 反应 16.0h， 以85%的产率得到17β-Methyl-5α-androstan
  参考文献：
  名称：

  具有改性碳骨架的雄甾烷

  摘要：

  制备了四种甾烷烃，用于与阿曼地质样品中的化石有机生物标志物进行比较。17β-甲基雌酮是通过六步（36% 的总产率）从雌酮甲基醚中制备的。该序列的关键步骤是 A 环的 Wittig 烯化和 Birch 还原。17β-甲基雄甾烷是通过四个官能团相互转化反应（包括 Wittig 烯化）从反式雄甾酮分四步（总产率为 85%）获得的。17β-甲基-和 2α-甲基-A-nor-5α-雄甾烷（总产率分别为 14% 和 15%）也由反式雄酮制备。关键步骤是三硝酸铊介导的 A 环酮环收缩为 A-nor-2-羧酸。四种合成中的去官能化是通过催化加氢、黄敏龙还原、巴顿脱羧、

  DOI：

  10.1002/ejoc.201100390
• 作为产物：
  描述：

  17-methylen-5α-androstanone-(3) 在 palladium-barium carbonate 、 乙醇 作用下， 生成 17β-methyl-5α-androstan-3-one
  参考文献：
  名称：

  Facilitating Children's Understanding of Misinterpretation: Explanatory Efforts and Improvements in Perspective Taking

  摘要：

  The authors investigated children's understanding of how mistaken beliefs can arise through misinterpretation of ambiguous information. Children (N = 91), aged 4 to 5 years, were given pre- and posttests on their ability to infer a puppet's interpretation of a restricted-view drawing after the puppet had been led to an erroneous expectation about the drawing's identity. Before the posttest, the children received either self-explanation training or other-explanation training in which they explained the source of their own or a puppet's misinterpretations of drawings; a control group received no training. The children who received training improved from pre- to posttest, and those who had practiced explaining misinterpretations by referring to previously viewed pictures or to features of a target picture showed the greatest improvement. These results indicate that learning to explain misinterpretations can help children recognize situations in which misinterpretations are likely to occur.

  DOI：

  10.1080/00221320209598673

文献信息

• METHODS TO INDUCE TARGETED PROTEIN DEGRADATION THROUGH BIFUNCTIONAL MOLECULES
  申请人：Dana-Farber Cancer Institute, Inc.

  公开号：US20160235731A1

  公开（公告）日：2016-08-18

  The present application provides bifunctional compounds which act as protein degradation inducing moieties. The present application also relates to methods for the targeted degradation of endogenous proteins through the use of the bifunctional compounds that link a cereblon-binding moiety to a ligand that is capable of binding to the targeted protein which can be utilized in the treatment of proliferative disorders. The present application also provides methods for making compounds of the application and intermediates thereof.

  本申请提供了具有蛋白质降解诱导基团作用的双功能化合物。本申请还涉及使用连接到能够与靶向蛋白质结合的配体的脑桥蛋白结合基团的双功能化合物，通过靶向降解内源性蛋白质的方法，可用于治疗增殖性疾病。本申请还提供了制备该申请中化合物及其中间体的方法。
• Protected monomers
  申请人：Manoharan Muthiah

  公开号：US20070179100A1

  公开（公告）日：2007-08-02

  This invention relates to protected monomers for the synthesis of iRNA agents.
• US9750816B2
  申请人：——

  公开号：US9750816B2

  公开（公告）日：2017-09-05
• Facilitating Children's Understanding of Misinterpretation: Explanatory Efforts and Improvements in Perspective Taking
  作者：Bradford H. Pillow、Clay Mash、Samuel Aloian、Valerie Hill

  DOI：10.1080/00221320209598673

  日期：2002.6

  The authors investigated children's understanding of how mistaken beliefs can arise through misinterpretation of ambiguous information. Children (N = 91), aged 4 to 5 years, were given pre- and posttests on their ability to infer a puppet's interpretation of a restricted-view drawing after the puppet had been led to an erroneous expectation about the drawing's identity. Before the posttest, the children received either self-explanation training or other-explanation training in which they explained the source of their own or a puppet's misinterpretations of drawings; a control group received no training. The children who received training improved from pre- to posttest, and those who had practiced explaining misinterpretations by referring to previously viewed pictures or to features of a target picture showed the greatest improvement. These results indicate that learning to explain misinterpretations can help children recognize situations in which misinterpretations are likely to occur.
• Androstanes with Modified Carbon Skeletons
  作者：Sascha Norden、Matthias Bender、Jürgen Rullkötter、Jens Christoffers

  DOI：10.1002/ejoc.201100390

  日期：2011.8

  Four sterane hydrocarbons were prepared for comparison with fossil organic biomarkers in geological samples from Oman. 17β-Methylestrane was prepared in six steps (36 % overall yield) from estrone methyl ether. Key steps of this sequence were a Wittig olefination and Birch reduction of the A-ring. 17β-Methylandrostane was obtained in four steps (85 % overall yield) from trans-androsterone by four functional

  制备了四种甾烷烃，用于与阿曼地质样品中的化石有机生物标志物进行比较。17β-甲基雌酮是通过六步（36% 的总产率）从雌酮甲基醚中制备的。该序列的关键步骤是 A 环的 Wittig 烯化和 Birch 还原。17β-甲基雄甾烷是通过四个官能团相互转化反应（包括 Wittig 烯化）从反式雄甾酮分四步（总产率为 85%）获得的。17β-甲基-和 2α-甲基-A-nor-5α-雄甾烷（总产率分别为 14% 和 15%）也由反式雄酮制备。关键步骤是三硝酸铊介导的 A 环酮环收缩为 A-nor-2-羧酸。四种合成中的去官能化是通过催化加氢、黄敏龙还原、巴顿脱羧、