(2Z,2'Z)-N,N'-(1,3-phenylenebis(methylene))bis(2-cyano-3-(1H-imidazol-5-yl)acrylamide) | 1567834-57-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (2Z,2'Z)-N,N'-(1,3-phenylenebis(methylene))bis(2-cyano-3-(1H-imidazol-5-yl)acrylamide)
• 英文别名: (Z)-2-cyano-N-[[3-[[[(Z)-2-cyano-3-(1H-imidazol-5-yl)prop-2-enoyl]amino]methyl]phenyl]methyl]-3-(1H-imidazol-5-yl)prop-2-enamide
• CAS: 1567834-57-4
• 化学式: C₂₂H₁₈N₈O₂
• 分子量: 426.437
• InChiKey: MKSKXWABRXIVHR-OYUQAUEZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  32
• 可旋转键数：
  8
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  163
• 氢给体数：
  4
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  间苯二甲胺 在 哌啶 作用下， 以 乙醇 为溶剂， 反应 23.0h， 生成 (2Z,2'Z)-N,N'-(1,3-phenylenebis(methylene))bis(2-cyano-3-(1H-imidazol-5-yl)acrylamide)
  参考文献：
  名称：

  Degrasyn-like symmetrical compounds: Possible therapeutic agents for multiple myeloma (MM-I)

  摘要：

  A series of degrasyn-like symmetrical compounds have been designed, synthesized, and screened against B cell malignancy (multiple myeloma, mantle cell lymphoma) cell lines. The lead compounds T5165804 and CP2005 showed higher nanomolar potency against these tumor cells in comparison to degrasyn and inhibited Usp9x activity in vitro and in intact cells. These observations suggest that this new class of compounds holds promise as cancer therapeutic agents. (C) 2014 Published by Elsevier Ltd.

  DOI：

  10.1016/j.bmc.2013.12.048

文献信息

• Kinase inhibitors for preventing or treating pathogen infection and method of use thereof
  申请人：Emory University

  公开号：EP2364702A2

  公开（公告）日：2011-09-14

  A composition is provided which comprises one or more Kinase inhibitors for use for preventing or treating a pathogenic infection caused by a broad array of pathogens in a patient in need thereof.

  本发明提供了一种组合物，其中包含一种或多种激酶抑制剂，用于预防或治疗由多种病原体引起的病原体感染。
• Kinase Inhibitors for Preventing or Treating Pathogen Infection and Method of Use Thereof
  申请人：Emory University

  公开号：EP2471529A2

  公开（公告）日：2012-07-04

  A composition is provided which comprises one or more Kinase inhibitors for use for preventing or treating a pathogenic infection caused by a broad array of pathogens in a patient in need thereof.

  本发明提供了一种组合物，其中包含一种或多种激酶抑制剂，用于预防或治疗由多种病原体引起的病原体感染。
• KINASE INHIBITORS FOR PREVENTING OR TREATING PATHOGEN INFECTION AND METHOD OF USE THEREOF
  申请人：Kalman Daniel

  公开号：US20120302565A1

  公开（公告）日：2012-11-29

  The present invention provides compositions and methods of use thereof to prevent and/or treat pathogenic infection. In particular, the present invention provides the use of kinase inhibitors to inhibit kinases that involve in pathogen-host cell interactions that are associated with or cause pathogenic infections, therefore, to effectively prevent and/or treat pathogenic infections with far less likely to engender resistance as compared to conventional antibiotics and anti-viral drugs. The present invention further provides the use of kinase inhibitors for the treatment of acute pathogenic infections for a short period of time to avoid toxicities that may caused by long term use of these kinase inhibitors.
• US8268809B2
  申请人：——

  公开号：US8268809B2

  公开（公告）日：2012-09-18
• Degrasyn-like symmetrical compounds: Possible therapeutic agents for multiple myeloma (MM-I)
  作者：Zhenghong Peng、David S. Maxwell、Duoli Sun、Basvoju A. Bhanu Prasad、Paul T. Schuber、Ashutosh Pal、Yunming Ying、Dongmei Han、Liwei Gao、Shimei Wang、Alexander Levitzki、Vaibhav Kapuria、Moshe Talpaz、Matthew Young、Hollis D. Showalter、Nicholas J. Donato、William G. Bornmann

  DOI：10.1016/j.bmc.2013.12.048

  日期：2014.2

  A series of degrasyn-like symmetrical compounds have been designed, synthesized, and screened against B cell malignancy (multiple myeloma, mantle cell lymphoma) cell lines. The lead compounds T5165804 and CP2005 showed higher nanomolar potency against these tumor cells in comparison to degrasyn and inhibited Usp9x activity in vitro and in intact cells. These observations suggest that this new class of compounds holds promise as cancer therapeutic agents. (C) 2014 Published by Elsevier Ltd.