4'-[(dimethylamino)carbonyl]-4-biphenylcarboxylic acid | 582325-13-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4'-[(dimethylamino)carbonyl]-4-biphenylcarboxylic acid
• 英文别名: 4-[4-(N,N-Dimethylaminocarbonyl)phenyl]benzoic acid；4-[4-(dimethylcarbamoyl)phenyl]benzoic acid
• CAS: 582325-13-1
• 化学式: C₁₆H₁₅NO₃
• 分子量: 269.3
• InChiKey: CPMMPKSYQSRTSZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  20
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  57.6
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  4'-[(dimethylamino)carbonyl]-4-biphenylcarboxylic acid 、 7-氨基-1-甲基-1,2,3,4-四氢喹啉 在 4-二甲氨基吡啶 、 盐酸-N-乙基-Nˊ-(3-二甲氨基丙基)碳二亚胺 作用下， 以 二氯甲烷 为溶剂， 生成 4-[4-(dimethylcarbamoyl)phenyl]-N-(1-methyl-3,4-dihydro-2H-quinolin-7-yl)benzamide
  参考文献：
  名称：

  N-Tetrahydroquinolinyl, N-quinolinyl and N-isoquinolinyl biaryl carboxamides as antagonists of TRPV1

  摘要：

  Starting from the high throughput screening hit (3), novel N-tetrahydroquinolinyl, N-quinolinyl and N-isoquinolinyl carboxamides have been identified as potent antagonists of the ion channel TRPV1. The N-quinolinylnicotinamide (46) showed excellent potency at human, guinea pig and rat TRPV1, a favourable in vitro DMPK profile and activity in an in vivo model of inflammatory pain. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2006.06.026

文献信息

• Aryl piperidine derivatives as inducers of ldl-receptor expression for the treatment of hypercholesterolemia
  申请人：Bouillot Jeanne Anne Marie

  公开号：US20060052384A1

  公开（公告）日：2006-03-09

  This invention relates to novel compounds which up-regulate LDL receptor (LDL-r) expression and to processes for their preparation, pharmaceutical compositions containing them and their medical use. More particularly, this invention relates to novel aromatic piperidines and their use in therapy.

  本发明涉及一种新型化合物，其上调LDL受体（LDL-r）表达，并涉及其制备过程、含有它们的制药组合物及其医学用途。更具体地说，本发明涉及新型芳香基哌啶及其在治疗中的应用。
• N-Tetrahydroquinolinyl, N-quinolinyl and N-isoquinolinyl biaryl carboxamides as antagonists of TRPV1
  作者：Susan M. Westaway、Ying-Kit Chung、John B. Davis、Vicky Holland、Jeffrey C. Jerman、Stephen J. Medhurst、Harshad K. Rami、Geoffrey Stemp、Alexander J. Stevens、Mervyn Thompson、Kim Y. Winborn、James Wright

  DOI：10.1016/j.bmcl.2006.06.026

  日期：2006.9

  Starting from the high throughput screening hit (3), novel N-tetrahydroquinolinyl, N-quinolinyl and N-isoquinolinyl carboxamides have been identified as potent antagonists of the ion channel TRPV1. The N-quinolinylnicotinamide (46) showed excellent potency at human, guinea pig and rat TRPV1, a favourable in vitro DMPK profile and activity in an in vivo model of inflammatory pain. (c) 2006 Elsevier Ltd. All rights reserved.