N-[5-(diethylsulfamoyl)-2-morpholin-4-ylphenyl]-2-pyridin-2-ylquinoline-4-carboxamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-[5-(diethylsulfamoyl)-2-morpholin-4-ylphenyl]-2-pyridin-2-ylquinoline-4-carboxamide
• 化学式: C₂₉H₃₁N₅O₄S
• 分子量: 545.7
• InChiKey: SIDMMGVBIKMQRL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  39
• 可旋转键数：
  8
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.28
• 拓扑面积：
  113
• 氢给体数：
  1
• 氢受体数：
  8

文献信息

• Acridine and Quinoline Derivatives as Sirtuin Modulators
  申请人：Milburn Michael

  公开号：US20090069301A1

  公开（公告）日：2009-03-12

  Provided herein are novel sirtuin-modulating compounds and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders related to aging or stress, diabetes, obesity, neurodegenerative diseases, chemotherapeutic induced neuropathy, neuropathy associated with an ischemic event, polyglutamine diseases, ocular diseases and/or disorders, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing. Also provided are compositions comprising a sirtuin-modulating compound in combination with another therapeutic agent.

  本文提供了新颖的sirtuin调节化合物及其使用方法。这些sirtuin调节化合物可用于增加细胞寿命，并治疗和/或预防各种疾病和疾病，包括与衰老或压力有关的疾病或疾病，糖尿病，肥胖症，神经退行性疾病，化疗引起的神经病理性疼痛，缺血事件相关的神经病理性疼痛，多谷氨酸疾病，眼部疾病和/或疾病，心血管疾病，血栓形成障碍，炎症，癌症和/或潮红。还提供了包含sirtuin调节化合物与另一种治疗剂组合的组合物。
• FLUORESCENCE POLARIZATION ASSAYS FOR ACETYLTRANSFERASE/DEACETYLASE ACTIVITY
  申请人：Sirtris Pharmaceuticals, Inc.

  公开号：EP1853920B1

  公开（公告）日：2012-02-01
• Fluorescence Polarization Assays for Acetyltransferase/Deacetylase Activity
  申请人：Milne Jill

  公开号：US20080293081A1

  公开（公告）日：2008-11-27

  Provided are methods for determining the activity of proteins that modulate the acetylation state of a protein substrate. The methods may be used for determining both acetyltransferase activity and deacetylase activity. The methods involve fluorescence polarization measurements for determining the acetylation state of a substrate peptide. The methods may also be used to identify compounds that modulate the activity of a protein having acetyltransferase or deacetylase activity. Also provided are substrates for acetyltransferase or deacetylase enzymes for use in association with a fluorescence polarization assay.
• Therapeutic compounds and related methods of use
  申请人：Huber L. Julie

  公开号：US20100168084A1

  公开（公告）日：2010-07-01

  Methods of using compounds that are HAT inhibitors are described herein.