2-[[Benzyl(2-hydroxyethyl)amino]methyl]pyridin-3-ol | 7254-17-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-[[Benzyl(2-hydroxyethyl)amino]methyl]pyridin-3-ol
• CAS: 7254-17-3
• 化学式: C₁₅H₁₈N₂O₂
• 分子量: 258.32
• InChiKey: AFLXMTXOVRGNMC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  19
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  56.6
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• Prodrugs of a 3-(pyrrol-2-ylmethylidene)-2-indolinone derivatives
  申请人：Sugen. Inc.

  公开号：US20030100555A1

  公开（公告）日：2003-05-29

  The present invention relates to pyrrole substituted 2-indolinone compounds and their pharmaceutically acceptable salts which modulate the activity of protein kinases and therefore are expected to be useful in the prevention and treatment of protein kinase related cellular disorders such as cancer.

  本发明涉及吡咯替代的2-吲哚酮化合物及其药学上可接受的盐，这些化合物调节蛋白激酶的活性，因此预计在预防和治疗蛋白激酶相关的细胞疾病，如癌症方面具有用处。
• MANGANESE-BEARING POLYMER COMPLEXES
  申请人：Umicore

  公开号：EP3674340A1

  公开（公告）日：2020-07-01

  The invention concerns a composition for use as drier in auto-oxidizable coatings or as accelerator in unsaturated polyester resins, comprising a manganese-bearing polymer having a manganese dicarboxylate repeating unit and at least one nitrogen-containing donor ligand. Such compositions offer excellent drying performances. They ensure a strongly reduced leachability of manganese compared to that of known manganese-bearing driers.

  本发明涉及一种在自动氧化涂料中用作干燥剂或在不饱和聚酯树脂中用作促进剂的组合物，该组合物由具有二羧酸锰重复单元和至少一个含氮供体配位体的含锰聚合物组成。这种组合物具有优异的干燥性能。与已知的含锰干燥剂相比，它们可确保大大降低锰的浸出率。
• US6797725B2
  申请人：——

  公开号：US6797725B2

  公开（公告）日：2004-09-28
• US7053114B2
  申请人：——

  公开号：US7053114B2

  公开（公告）日：2006-05-30
• [EN] PRODRUGS OF 3-(PYRROL-2-YLMETHYLIDENE)-2-INDOLINONE DERIVATIVES<br/>[FR] PROMEDICAMENTS A BASE DE DERIVES 3-(PYRROL-2-YLMETHYLIDENE)-2-INDOLINONE
  申请人：SUGEN INC

  公开号：WO2002081466A1

  公开（公告）日：2002-10-17

  The present invention relates to pyrrole substituted 2-indolinone compounds and their pharmaceutically acceptable salts which modulate the activity of protein kinases and therefore are expected to be useful in the prevention and treatment of protein kinase related cellular disorders such as cancer.