N-(3-羟基苯)-5-甲基-3-异恶唑甲酰胺 | 688051-07-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: N-(3-羟基苯)-5-甲基-3-异恶唑甲酰胺
• 英文名称: N-(3-Hydroxyphenyl)-5-methylisoxazole-3-carboxamide
• 英文别名: N-(3-hydroxyphenyl)-5-methyl-1,2-oxazole-3-carboxamide
• CAS: 688051-07-2
• 化学式: C₁₁H₁₀N₂O₃
• mdl: MFCD08691757
• 分子量: 218.212
• InChiKey: GEFKRASWMFTFSQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  75.4
• 氢给体数：
  2
• 氢受体数：
  4

安全信息

• 海关编码：
  2934999090

文献信息

• Isoxazole derivatives and methods of treating nitric oxide mediated diseases
  申请人：Shaw Jiajiu

  公开号：US20060223873A1

  公开（公告）日：2006-10-05

  A series of isoxazole derivatives and methods of suppressing, inhibiting, or preventing disorders mediated by nitric oxide (NO) and/or proinflammatory cytokines, such as TNF-α (tumor necrosis factor alpha), IL-1 (interlukin-1), and IL-6, are described.

  本文描述了一系列异唑啉衍生物及其抑制、抑制或预防由一氧化氮(NO)和/或促炎细胞因子引起的疾病的方法，例如TNF-α（肿瘤坏死因子α）、IL-1（白细胞介素1）和IL-6。
• NOVEL COMPOUND AND APPLICATION THEREOF IN TREATING INFLAMMATION OR INFLAMMATION-RELATED DISEASES
  申请人：SICHUAN CENTER FOR TRANSLATIONAL MEDICINE OF TRADITIONAL CHINESE MEDICINE

  公开号：US20210355093A1

  公开（公告）日：2021-11-18

  The present invention relates to a compound and the application thereof in treating inflammation or inflammation-related diseases, and more specifically to a compound UTLOH combination. Said compound effectively inhibits the level of LPS-induced PGE2 and NO, while effectively treating inflammatory or inflammatory-related diseases.
• US7291743B2
  申请人：——

  公开号：US7291743B2

  公开（公告）日：2007-11-06