2-chloro-4-(4-fluorobenzyloxy)pyridine | 924311-93-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-chloro-4-(4-fluorobenzyloxy)pyridine
• 英文别名: 2-Chloro-4-[(4-fluorobenzyl)oxy]pyridine；2-chloro-4-[(4-fluorophenyl)methoxy]pyridine
• CAS: 924311-93-3
• 化学式: C₁₂H₉ClFNO
• 分子量: 237.661
• InChiKey: QULGCIQIVNNJJT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  16
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  22.1
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-chloro-4-(4-fluorobenzyloxy)pyridine 在 甲酸 、 ammonium acetate 作用下， 以 水 为溶剂， 反应 144.0h， 以17%的产率得到4-[(4-fluorobenzyl)oxy]pyridine-2(1H)-one
  参考文献：
  名称：

  AZINONE-SUBSTITUTED AZEPINO[b]INDOLE AND PYRIDO-PYRROLO-AZEPINE MCH-1 ANTAGONISTS, METHODS OF MAKING, AND USE THEREOF

  摘要：

  揭示了新型MCH-1受体拮抗剂。这些化合物用于治疗各种疾病，包括肥胖、焦虑、抑郁、非酒精性脂肪肝病和精神疾病。本发明还描述了制备这些化合物的方法。

  公开号：

  US20110003793A1
• 作为产物：
  描述：

  4-[(4-fluorobenzyl)oxy]pyridine-2(1H)-one 在 三氯氧磷 作用下， 反应 2.0h， 生成 2-chloro-4-(4-fluorobenzyloxy)pyridine
  参考文献：
  名称：

  Discovery of novel phenethylpyridone derivatives as potent melanin-concentrating hormone 1 receptor antagonists

  摘要：

  Novel phenethylpyridone derivatives were identified as potent human melanin-concentrating hormone 1 receptor (MCH-1R) antagonists. A search for surrogates for the 4-(2-aminoethoxy) phenyl moiety of 1 resulted in discovery of 2-[4-(aminomethyl) phenyl] ethyl substructure as in 6a. Successive optimization of the right-hand moiety led to the identification of a number of potent derivatives. (C) 2009 Published by Elsevier Ltd.

  DOI：

  10.1016/j.bmcl.2009.07.023

文献信息

• Pyridone Compounds
  申请人：Ando Makoto

  公开号：US20100216758A1

  公开（公告）日：2010-08-26

  An active ingredient is a compound represented by the general formula [I]: [wherein R 1 and R 2 represent a lower alkyl group, a C 3-6 cycloalkyl group or the like, X 1 and X 2 represent methine, an Ar—Y 1 —Y 2 —Y 3 -substituted methine or the like, however either of them is an Ar—Y 1 —Y 2 —Y 3 -substituted methine, X 3 to X 8 represent methine, —N— or the like, Y 1 and Y 3 represent a single bond, —O— or the like, Y 2 represent a single bond, a lower alkylene group or the like, W represent —(O)—(CH 2 )n-(O)— or the like, n represents an integer of 1 to 4, L and Z 2 represent a single bond or a methylene group, Z 1 represents a single bond, a C 1-4 alkylene group or the like, and Ar represents an aromatic carbocyclic group or the like]. The compound acts as a melanin-concentrating hormone receptor antagonist and useful as a therapeutic agent for obesity or the like.

  活性成分是由通式[I]表示的化合物：[其中R1和R2表示低级烷基、C3-6环烷基或类似物，X1和X2表示亚甲基、Ar—Y1—Y2—Y3取代亚甲基或类似物，但其中任一种为Ar—Y1—Y2—Y3取代亚甲基，X3到X8表示亚甲基、—N—或类似物，Y1和Y3表示单键、—O—或类似物，Y2表示单键、低级烷基亚ethylene基或类似物，W表示—(O)—(CH2)n-(O)—或类似物，n表示1到4的整数，L和Z2表示单键或亚甲基，Z1表示单键、C1-4烷基亚ethylene基或类似物，Ar表示芳香族碳环基或类似物]。该化合物作为黑色素浓缩激素受体拮抗剂，可用作治疗肥胖症或类似疾病的治疗剂。
• PYRIDONE COMPOUND
  申请人：BANYU PHARMACEUTICAL CO., LTD.

  公开号：EP1916239A1

  公开（公告）日：2008-04-30

  An active ingredient is a compound represented by the general formula [I]: [wherein R1 and R2 represent a lower alkyl group, a C3-6 cycloalkyl group or the like, X1 and X2 represent methine, an Ar-Y1-Y2-Y3-substituted methine or the like, however either of them is an Ar-Y1-Y2-Y3-substituted methine, X3 to X8 represent methine, -N- or the like, Y1 and Y3 represent a single bond, -O- or the like, Y2 represent a single bond, a lower alkylene group or the like, W represent -(O)-(CH2)n-(O)- or the like, n represents an integer of 1 to 4, L and Z2 represent a single bond or a methylene group, Z1 represents a single bond, a C1-4 alkylene group or the like, and Ar represents an aromatic carbocyclic group or the like]. The compound acts as a melanin-concentrating hormone receptor antagonist and useful as a therapeutic agent for obesity or the like.

  活性成分是由通式[I]表示的化合物： [其中 R1 和 R2 代表低级烷基、C3-6 环烷基或类似基团，X1 和 X2 代表甲烷、Ar-Y1-Y2-Y3 取代的甲烷或类似基团，但其中任一基团为 Ar-Y1-Y2-Y3 取代的甲烷，X3 至 X8 代表甲烷、-N- 或类似基团，Y1 和 Y3 代表单键、-O- 或类似基团、Y2 代表单键、低级亚烷基或类似基团，W 代表-(O)-(CH2)n-(O)-或类似基团，n 代表 1 至 4 的整数，L 和 Z2 代表单键或亚甲基，Z1 代表单键、C1-4 亚烷基或类似基团，Ar 代表芳香碳环基团或类似基团]。该化合物是一种黑色素浓缩激素受体拮抗剂，可用作肥胖症或类似疾病的治疗剂。
• EP1916239
  申请人：——

  公开号：——

  公开（公告）日：——
• AZINONE-SUBSTITUTED AZEPINO[B]INDOLE AND PYRIDO-PYRROLO-AZEPINE MCH-1 ANTAGONISTS, METHODS OF MAKING, AND USE THEREOF
  申请人：Albany Molecular Research, Inc.

  公开号：EP2448585B1

  公开（公告）日：2014-01-01
• US8637501B2
  申请人：——

  公开号：US8637501B2

  公开（公告）日：2014-01-28