4-oxo-4-(3-phenoxybenzyloxy)butanoic acid | 940867-23-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-oxo-4-(3-phenoxybenzyloxy)butanoic acid
• 英文别名: 4-Oxo-4-[(3-phenoxyphenyl)methoxy]butanoic acid
• CAS: 940867-23-2
• 化学式: C₁₇H₁₆O₅
• 分子量: 300.311
• InChiKey: SMHHKPGMMLRMKR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  22
• 可旋转键数：
  8
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  72.8
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  丁二酸酐 、 3-苯氧基苄醇 以 二氯甲烷 为溶剂， 以94%的产率得到4-oxo-4-(3-phenoxybenzyloxy)butanoic acid
  参考文献：
  名称：

  Immunoassay Development for the Class-Specific Assay for Types I and II Pyrethroid Insecticides in Water Samples

  摘要：

  我们设计并合成了五种拟除虫菊酯类杀虫剂的通用触媒（分为三类）：第一类（触媒 1）适用于不含氰基的 I 型拟除虫菊酯，第二类（触媒 2 和 XQ）适用于含氰基的 II 型拟除虫菊酯，第三类（触媒 4 和 5）适用于失去酯基的两种拟除虫菊酯。单体结构已通过 MS 和 1H-NMR 得到确认。单体 1 和 2 分别与 BSA 共轭，单体 1-5 与 OVA 共轭。针对 BSA 共轭物（包括一种混合共轭物）培养了四种多克隆抗体，并选择了 20 种抗体/包被共轭物组合，用于研究拟除虫菊酯的检测灵敏度和特异性。研究结果表明，最佳组合对两种除虫菊酯的敏感性相当高（I50 约为 0.02 μg mL-1）。免疫结果表明，使用混合共轭物可以制备出针对一组杀虫剂的多克隆抗体，用于多残留检测。

  DOI：

  10.3390/molecules15010164

文献信息

• Time-resolved fluorescent immunochromatographic assay rapid test kit for type I pyrethroid
  申请人：OILCROPS RESEARCH INSTITUTE OF CHINESE ACADAMY OF AGRICULTURE SCIENCES

  公开号：US10809252B2

  公开（公告）日：2020-10-20

  The present invention relates to a time-resolved fluorescent immunochromatographic assay rapid test kit for quantitative determination of the level of type I pyrethroid, which has the advantages of simple operation, rapid detection, and with high accuracy. The kit has a quantitative detection limit of 9.12 ng/mL for a type I pyrethroid sample. When the kit is applied to the detection of an actual sample of type I pyrethroid and by comparing the detection result obtained by HPLC, the kit has a coefficient of correlation of 0.986 (R2). Hence, the kit is applicable to the detection by using the actual samples of type I pyrethroid.

  本发明涉及一种用于定量检测 I 型拟除虫菊酯含量的时间分辨荧光免疫层析快速检测试剂盒，该试剂盒具有操作简单、检测快速、准确度高等优点。该试剂盒对 I 型拟除虫菊酯样品的定量检测限为 9.12 纳克/毫升。将该试剂盒应用于 I 型拟除虫菊酯实际样品的检测，通过比较 HPLC 的检测结果，试剂盒的相关系数为 0.986（R2）。因此，该试剂盒适用于使用 I 型拟除虫菊酯实际样品进行检测。
• TIME-RESOLVED FLUORESCENT IMMUNOCHROMATOGRAPHIC ASSAY RAPID TEST KIT FOR TYPE I PYRETHROID
  申请人：OILCROPS RESEARCH INSTITUTE OF CHINESE ACADAMY OF AGRICULTURE SCIENCES

  公开号：US20180246086A1

  公开（公告）日：2018-08-30

  The present invention relates to a time-resolved fluorescent immunochromatographic assay rapid test kit for quantitative determination of the level of type I pyrethroid, which has the advantages of simple operation, rapid detection, and with high accuracy. The kit has a quantitative detection limit of 9.12 ng/mL for a type I pyrethroid sample. When the kit is applied to the detection of an actual sample of type I pyrethroid and by comparing the detection result obtained by HPLC, the kit has a coefficient of correlation of 0.986 (R 2 ). Hence, the kit is applicable to the detection by using the actual samples of type I pyrethroid.
• Immunoassay Development for the Class-Specific Assay for Types I and II Pyrethroid Insecticides in Water Samples
  作者：Qi Zhang、Wen Zhang、Xiuping Wang、Peiwu Li

  DOI：10.3390/molecules15010164

  日期：——

  Five generic haptens of pyrethoid insecticides, which were classified as three types, were designed and synthesized: the first (hapten 1) is for type I pyrethroids without a cyano group, the second (hapten 2 and XQ) for type II pyrethroids with a cyano group, and the third (hapten 4 and 5) for both types of pyrethroids with loss of the ester group. The hapten structures were confirmed by MS and 1H-NMR. Hapten 1 and 2 were conjugated with BSA respectively and haptens 1-5 were conjugated with OVA. Four polyclonal antisera were raised against BSA conjugates including a mixture conjugate, and twenty antibody/coating conjugate combinations were selected for studies of assay sensitivity and specificity for pyrethroids. The study revealed the best combination, which showed equal high sensitivities (I50 is around 0.02 μg mL-1) to both types of pyrethroids. The immunity results suggest that, with a mixture conjugates, a polyclonal antibody against a group of insecticides can be prepared for multi-residue assays.

  我们设计并合成了五种拟除虫菊酯类杀虫剂的通用触媒（分为三类）：第一类（触媒 1）适用于不含氰基的 I 型拟除虫菊酯，第二类（触媒 2 和 XQ）适用于含氰基的 II 型拟除虫菊酯，第三类（触媒 4 和 5）适用于失去酯基的两种拟除虫菊酯。单体结构已通过 MS 和 1H-NMR 得到确认。单体 1 和 2 分别与 BSA 共轭，单体 1-5 与 OVA 共轭。针对 BSA 共轭物（包括一种混合共轭物）培养了四种多克隆抗体，并选择了 20 种抗体/包被共轭物组合，用于研究拟除虫菊酯的检测灵敏度和特异性。研究结果表明，最佳组合对两种除虫菊酯的敏感性相当高（I50 约为 0.02 μg mL-1）。免疫结果表明，使用混合共轭物可以制备出针对一组杀虫剂的多克隆抗体，用于多残留检测。