N-(4-(乙基氨基)苯基)-甲烷磺酰胺 | 94237-49-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: N-(4-(乙基氨基)苯基)-甲烷磺酰胺
• 英文名称: Methanesulfonamide, N-(4-(ethylamino)phenyl)-
• 英文别名: N-[4-(ethylamino)phenyl]methanesulfonamide
• CAS: 94237-49-7
• 化学式: C₉H₁₄N₂O₂S
• 分子量: 214.29
• InChiKey: CIINTKFRIWDBPP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  14
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  66.6
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• [EN] 4-(METHYL SULFONYL AMINO) PHENYL ANALOGUES AS VANILLOID ANTAGONIST SHOWING EXCELLENT ANALGESIC ACTIVITY AND THE PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME<br/>[FR] ANALOGUES DE 4-(METHYL SULFONYL AMINO)PHENYLE UTILISES EN TANT QU'ANTAGONISTES DU RECEPTEUR VANILLOIDE AYANT UNE EXCELLENTE ACTIVITE ANALGESIQUE, ET COMPOSITIONS PHARMACEUTIQUE LES COMPRENANT
  申请人：DIGITALBIOTECH CO LTD

  公开号：WO2005003084A1

  公开（公告）日：2005-01-13

  The present invention relates to novel 4-(methylsulfonylamino) phenyl analogue as a potent vanilloid receptor antagonist and the pharmaceutical compositions comprising the same. The inventive compound can be useful for analgesics to prevent, alleviate or treat pain diseases or inflammatory disease comprising pain, acute pain, chronic pain, neuropathic pain, post-operative pain, migraine, arthralgia, neuropathies, nerve injury, diabetic neuropathy, neurodegeneration, neurotic skin disorder, stroke, urinary bladder hypersensitiveness, irritable bowel syndrome, a respiratory disorder such as asthma or chronic obstructive pulmonary disease, irritation of skin, eye or mucous membrane, fervescence, stomach-duodenal ulcer, inflammatory bowel disease, inflammatory disease and urgent urinary incontinence.

  本发明涉及一种新型的4-(甲磺胺基)苯基类似物，作为有效的辣椒素受体拮抗剂，以及包含该类似物的药物组合物。这种创新化合物可用于镇痛药，用于预防、缓解或治疗疼痛疾病或包括疼痛的炎症性疾病，如急性疼痛、慢性疼痛、神经痛、术后疼痛、偏头痛、关节痛、神经病、神经损伤、糖尿病性神经病、神经退行性疾病、神经性皮肤疾病、中风、膀胱过敏、肠易激综合征、哮喘或慢性阻塞性肺疾病等呼吸道疾病、皮肤、眼睛或粘膜的刺激、发热、胃十二指肠溃疡、炎症性肠病、炎症性疾病和急性尿失禁。
• [EN] NOVEL THIOUREA DERIVATIVES AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME<br/>[FR] NOUVEAUX DERIVES DE THIOUREA ET COMPOSITIONS PHARMACEUTIQUES RENFERMANT CEUX-CI
  申请人：PACIFIC CORP

  公开号：WO2002016318A1

  公开（公告）日：2002-02-28

  The present invention relates to novel thiourea derivatives as a modulator for vanilloid receptor (VR) and the pharmaceutical compositions containing the same. As diseases associated with the activity of vanilloid receptor, pain acute pain, chronic pain, neuropathic pain, post-operative pain, migraine, arthralgia, neuropathies, nerve injury, diabetic neuropathy, neurodegeneration, neurotic skin disorder, stroke, urinary bladder hypersensitiveness, irritable bowel syndrome, a respiratory disorder such as asthma or chronic obstructive pulmonary disease, irritation of skin, eye or mucous membrane, fervescence, stomach-duodenal ulcer, inflammatory bowel disease and inflammatory diseases can be enumerated. The present invention provides a pharmaceutical composition for prevention or treatment of these diseases.

  本发明涉及一种新型硫脲衍生物，作为vanilloid受体（VR）的调节剂以及含有该化合物的制药组合物。作为与vanilloid受体活性相关的疾病，可以列举急性疼痛、慢性疼痛、神经病性疼痛、术后疼痛、偏头痛、关节痛、神经病变、神经损伤、糖尿病神经病变、神经退行性疾病、神经性皮肤疾病、中风、膀胱过敏、肠易激综合症、哮喘或慢性阻塞性肺疾病、皮肤、眼或粘膜刺激、发热、胃十二指肠溃疡、炎症性肠病和炎症性疾病等。本发明提供了用于预防或治疗这些疾病的制药组合物。
• Photographic element containing a substituted 4-nitrophenylazo-1-naphthol cyan dye
  申请人：EASTMAN KODAK COMPANY (a New Jersey corporation)

  公开号：EP0176075A2

  公开（公告）日：1986-04-02

  Photographic elements and diffusion transfer assemblages are described which employ a non-diffusible 4-nitrophenylazo-1-naphthol compound having a 5-benzenesulfonamido or 5-benzenecarbonamido substituent which contains an ortho alkoxy or aryloxy group. In a preferred embodiment, the compound is capable of releasing at least one diffusible cyan dye moiety and has the formula: wherein:- (a) J represents S02 or CO, (b) R represents a substituted or unsubstituted alkyl group of from 1 to 10 carbon atoms or a substituted or unsubstituted aryl group of from 6 to 12 carbon atoms, (c) G represents a hydroxy group, a salt thereof, or a hydrolyzable precursor thereof, (d) CAR represents a ballasted carrier moiety, and (e) D', D2, and D3 each independently represents H or one or more electron-withdrawing groups selected from -SO2Y1, -CONY'Y2, -Cl, -COY', -C≡N and -SO2NY21Y2, where Y' and Y2 each independently represents hydrogen, a substituted or unsubstituted alkyl group of from 1 to 10 carbon atoms or a substituted or unsubstituted aryl group of from 6 to 12 carbon atoms. The released dyes have improved stability to light.

  本文描述的照相元件和扩散转移组件采用了一种不可扩散的 4-硝基苯偶氮-1-萘酚化合物，该化合物具有一个 5-苯磺酰胺基或 5-苯甲酰胺基取代基，该取代基含有一个正交烷氧基或芳氧基。 在一个优选的实施方案中，该化合物能释放出至少一种可扩散的青色染料分子，其分子式如下： 其中 (a) J 代表 S02 或 CO、 (b) R 代表 1 至 10 个碳原子的取代或未取代的烷基或 6 至 12 个碳原子的取代或 未取代的芳基、 (c) G 代表羟基、其盐或其可水解前体、 (d) CAR 代表压载载体分子，以及 (e) D'、D2 和 D3 各自独立地代表 H 或一个或多个选自-SO2Y1、-CONY'Y2、-Cl、-COY'、-C≡N 和-SO2NY21Y2 的抽电子基团，其中 Y' 和 Y2 各自独立地代表氢、1 至 10 个碳原子的取代或未取代的烷基或 6 至 12 个碳原子的取代或未取代的芳基。 释放出的染料具有更好的光稳定性。
• EP1303483A4
  申请人：——

  公开号：EP1303483A4

  公开（公告）日：2004-11-03
• NOVEL THIOUREA DERIVATIVES AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME
  申请人：PACIFIC CORPORATION

  公开号：EP1303483A1

  公开（公告）日：2003-04-23